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Protopanaxatriol ameliorates diabetic retinopathy by regulating mTOR/G6PD mediated pentose phosphate pathway
Protopanaxatriol ameliorates diabetic retinopathy by regulating mTOR/G6PD mediated pentose phosphate pathway
In traditional Chinese medicine (TCM), Panax notoginseng and Panax notoginseng saponins (PNS) have been widely used to tre...
Jasminumosides F–K, oligomeric secoiridoid glycosides from jasmin: the flowers of (L.) Aiton
Jasminumosides F–K, oligomeric secoiridoid glycosides from jasmin: the flowers of (L.) Aiton
Six new oligomeric secoiridoid glycosides, namely jasminumosides F–K (1–6), were isolated from the methanolic ...
Meroterpenoids from the fruiting body of with inhibitory activities against budded-to-hyphal-form transition and biofilm formation
Meroterpenoids from the fruiting body of with inhibitory activities against budded-to-hyphal-form transition and biofilm formation
Six novel meroterpenoids, dispanoic acids A–C (1–3), 2′-hydroxydaurichromanic acid (4), albatrellutin A ...
Isoliquiritigenin combined with gemcitabine inhibited lung cancer by suppressing JAK2/STAT3 signaling via lncRNA-p21/miRNA-4534 axis
Isoliquiritigenin combined with gemcitabine inhibited lung cancer by suppressing JAK2/STAT3 signaling via lncRNA-p21/miRNA-4534 axis
Isoliquiritigenin (2’-4’-4-trihydroxychalcone, ISL), a flavonoid from the herbal medicine Glycyrrhiza uralensi...
Antioxidative Japanese herbal medicine formula prevents diabetic renal complications
Antioxidative Japanese herbal medicine formula prevents diabetic renal complications
Diabetes is the leading cause of chronic kidney disease. Hyperglycaemia in diabetes promotes the generation of reactive ox...
A plant alkaloid lycorine inhibits non-small cell lung cancer cell proliferation, metastasis, glycolysis and promotes ferroptosis through the ZNF143/SPC25 axis
A plant alkaloid lycorine inhibits non-small cell lung cancer cell proliferation, metastasis, glycolysis and promotes ferroptosis through the ZNF143/SPC25 axis
Lycorine has been shown to have anti-tumor activity in many cancers, including non-small cell lung cancer (NSCLC). However...
Betulinic acid increases brain-derived neurotrophic factor expression via the PKA, NMDA receptor, and calcineurin pathways in cultured cortical neurons
Betulinic acid increases brain-derived neurotrophic factor expression via the PKA, NMDA receptor, and calcineurin pathways in cultured cortical neurons
Brain-derived neurotrophic factor (BDNF) is a crucial neurotrophin that plays a vital role in neuronal survival, synaptic ...
Chemistry and bioactivities of erinacines from fungi
Chemistry and bioactivities of erinacines from fungi
Erinacines are a class of cyathane diterpenoids predominantly biosynthesized in the mycelia of the medicinal mushroom Heri...
Olive () phenolics for the control of psoriasis via targeting SMYD2 and IL-17A protein–protein interaction networks
Olive () phenolics for the control of psoriasis via targeting SMYD2 and IL-17A protein–protein interaction networks
Psoriasis is a chronic immune-mediated skin disease characterized by keratinocyte hyperproliferation and persistent inflam...
New meroterpenoids from as inhibitors of amyloid β aggregation
New meroterpenoids from as inhibitors of amyloid β aggregation
Three new meroterpenoids, macrocarquinoids J(1)–L(3) were isolated from brown alga, Sargassum macrocarpum, along wit...
Inhibitory effects of three genuine resin glycosides from on porcine lipase assay and docking simulation analysis
Inhibitory effects of three genuine resin glycosides from on porcine lipase assay and docking simulation analysis
Resin glycosides are characteristically present in Convolvulaceae plants. We recently demonstrated that three genuine resi...
Suppression LIF with 8-Gingerol blockades colorectal cancer tumorigenesis by reversing M2-type macrophage polarization
Suppression LIF with 8-Gingerol blockades colorectal cancer tumorigenesis by reversing M2-type macrophage polarization
Colorectal cancer (CRC) remains a formidable therapeutic challenge, with persistent difficulties in developing therapies t...
Neoflavonoids and a megastigmane glycoside from : structural elucidation and biological evaluation
Neoflavonoids and a megastigmane glycoside from : structural elucidation and biological evaluation
A phytochemical investigation of the twigs and stems of Dalbergia cultrata yielded fourteen secondary metabolites, includi...
Effects of extraction methods on the phase, composition, bacteriostatic effect of - decoction
Effects of extraction methods on the phase, composition, bacteriostatic effect of - decoction
The traditional co-decoction method of Radix Scutellariae-Rhizoma Coptidis generates amounts of supramoleculars and aggreg...
Biological activity of isomalabaricane compounds from the marine sponge
Biological activity of isomalabaricane compounds from the marine sponge
This study aimed to investigate the cytotoxic effects of isomalabaricane stellettins Q-V and globostelletins K-N, recently...
The mechanism of the water layer extract of water extract in the treatment of Hepatic fibrosis was investigated using HPLC-MS/MS and network pharmacology
The mechanism of the water layer extract of water extract in the treatment of Hepatic fibrosis was investigated using HPLC-MS/MS and network pharmacology
Hepatic fibrosis (HF) represents a critical stage in the progression of chronic liver disease, for which effective treatme...
A novel mechanism for treating acute lung injury with ligustilide: elucidation via network pharmacology and in vitro validation
A novel mechanism for treating acute lung injury with ligustilide: elucidation via network pharmacology and in vitro validation
Ligustilide inhibits the release of multiple inflammatory factors and alleviates acute lung injury (ALI), although its und...
Anti-asthmatic effects and ingredient annotation of the active fraction from
Anti-asthmatic effects and ingredient annotation of the active fraction from
This research aims to screen the active fraction and explore the action mechanism of Ganoderma lucidum to combat asthma us...
Recent advances in progress of natural anticoagulant active substances
Recent advances in progress of natural anticoagulant active substances
Thrombotic diseases pose a serious threat to human life and health. Anticoagulant drugs are used to treat and prevent thro...
Integrated network pharmacology and pharmacological evaluation to elucidate the effect and mechanism of the novel combination PMS in treatment of osteoporosis
Integrated network pharmacology and pharmacological evaluation to elucidate the effect and mechanism of the novel combination PMS in treatment of osteoporosis
Psoralen, magnoflorine and sweroside were main active components of Xian-Ling-Gu-Bao capsule. PMS (a combination of psoral...
Anti-cancer activity of the glycyrrhetinic acid derivatives with an inhibitory inflammatory microenvironment
Anti-cancer activity of the glycyrrhetinic acid derivatives with an inhibitory inflammatory microenvironment
The tumor inflammatory microenvironment plays an important role in tumor development, and the compounds which modulate tum...
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression
Atractylodin (ATR) is a natural sesquiterpene compound primarily isolated from the rhizomes of Atractylodes, a plant of th...
Metabolite derived from green tea polyphenol increases and activates plasmacytoid dendritic cells
Metabolite derived from green tea polyphenol increases and activates plasmacytoid dendritic cells
The immune system plays a crucial role in protecting the body from harmful bacterial, viral infections and vital for cance...
Drimane sesquiterpenoids from cultures of basidiomycete
Drimane sesquiterpenoids from cultures of basidiomycete
Nine previously undescribed drimane sesquiterpenoids, ganoresinosins A–I (1–9), were isolated from cultures of...
Ameliorative role of leaf extract in aluminum chloride-induced neurotoxicity flies possibly mediated by -methyl--aspartate receptor antagonistic and anticholinesterase active compounds
Ameliorative role of leaf extract in aluminum chloride-induced neurotoxicity flies possibly mediated by -methyl--aspartate receptor antagonistic and anticholinesterase active compounds
Polyscias fruticosa leaves have been used in traditional medicine to aid in the therapy of brain and nerve-related disorde...
Apoptosis-inducing activity of a steroidal glycoside from G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress
Apoptosis-inducing activity of a steroidal glycoside from G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress
A saponin fraction from Allium chinense G. Don. bulbs has previously been reported to exhibit cytotoxicity against melanom...
ameliorated LPS-induced depression-like behaviors via suppression of acute neuroinflammation
ameliorated LPS-induced depression-like behaviors via suppression of acute neuroinflammation
Research context reveals that major depressive disorder (MDD), as a prevalent chronic relapsing psychiatric condition affe...
Advanced multidimensional quality evaluation of encapsulated peppermint oil products in various formulas
Advanced multidimensional quality evaluation of encapsulated peppermint oil products in various formulas
We investigated the actual label indications and quality of encapsulated peppermint oil (PO) products marketed as medicina...
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway
Osteoarthritis (OA) is the most common degenerative musculoskeletal disorder worldwide. Diosmetin is the aglycone of diosm...
Anti-allergic actions and pharmacokinetics of orally administered 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in mice
Anti-allergic actions and pharmacokinetics of orally administered 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in mice
In this study, we explored the anti-allergic actions of 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acids (18...
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