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An international observational study validating gene-expression sepsis immune subgroups
An international observational study validating gene-expression sepsis immune subgroups
Sepsis gene-expression sub-phenotypes with prognostic and theranostic potential have been discovered. These have been iden...
Study on the diagnostic role of exosome-derived miRNAs in postoperative septic shock and non-septic shock patients
Study on the diagnostic role of exosome-derived miRNAs in postoperative septic shock and non-septic shock patients
Diagnosing septic shock promptly is essential but challenging, especially due to its clinical similarity to non-septic sho...
Electrical impedance tomography-guided the optimal awake prone position in a moderate ARDS patient
Electrical impedance tomography-guided the optimal awake prone position in a moderate ARDS patient
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Alterations in the lipid profile of critically ill children in relation to outcome
Alterations in the lipid profile of critically ill children in relation to outcome
Critically ill adults typically develop hypocholesterolemia, associated with poor outcome. Whether similar alterations occ...
Early administration of high protein for critically ill patients with acute kidney injury?
Early administration of high protein for critically ill patients with acute kidney injury?
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Reflections from the bedside: a nursing perspective on three decades of intensive care
Reflections from the bedside: a nursing perspective on three decades of intensive care
Since critical care’s inception in the 1950s, nursing has been central in its development. Critical care nurses were and r...
Whole blood transcriptomics identifies subclasses of pediatric septic shock
Whole blood transcriptomics identifies subclasses of pediatric septic shock
Sepsis is a highly heterogeneous syndrome, which has hindered the development of effective therapies. This has prompted in...
Do critical illness survivors with multimorbidity need a different model of care?
Do critical illness survivors with multimorbidity need a different model of care?
There is currently a lack of evidence on the optimal strategy to support patient recovery after critical illness. Previous...
Meta-analysis of pulse pressure variation (PPV) and stroke volume variation (SVV) studies: a few rotten apples can spoil the whole barrel
Meta-analysis of pulse pressure variation (PPV) and stroke volume variation (SVV) studies: a few rotten apples can spoil the whole barrel
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis
Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis
Proenkephalin A 119-159 (PENK) is freely filtered in the glomerulus with plasma levels correlating with glomerular filtrat...
Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study
Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study
Observational studies have indicated a potential association between autoimmune diseases and the occurrence of sepsis, wit...
Potential confounders in linking elevated S100A8/A9 to left ventricular dysfunction in septic shock patients
Potential confounders in linking elevated S100A8/A9 to left ventricular dysfunction in septic shock patients
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Targeting the host response in sepsis: current approaches and future evidence
Targeting the host response in sepsis: current approaches and future evidence
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of the leading causes of death wo...
Comparing outcomes of out-of-hospital cardiac arrest patients with initial shockable rhythm in Singapore and Osaka using population-based databases
Comparing outcomes of out-of-hospital cardiac arrest patients with initial shockable rhythm in Singapore and Osaka using population-based databases
Previous research indicated outcomes among refractory out-of-hospital cardiac arrest (OHCA) patients with initial shockabl...
Critical illness among patients experiencing homelessness: a retrospective cohort study
Critical illness among patients experiencing homelessness: a retrospective cohort study
To understand the epidemiology and healthcare use of critically ill patients experiencing homelessness compared to critica...
Prognostic value of capillary refill time in adult patients: a systematic review with meta-analysis
Prognostic value of capillary refill time in adult patients: a systematic review with meta-analysis
Acute circulatory failure leads to tissue hypoperfusion. Capillary refill time (CRT) has been widely studied, but its pred...
Iron as an emerging therapeutic target in critically ill patients
Iron as an emerging therapeutic target in critically ill patients
The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases...
Remimazolam besylate versus propofol for deep sedation in critically ill patients: a randomized pilot study
Remimazolam besylate versus propofol for deep sedation in critically ill patients: a randomized pilot study
To compare the efficacy and safety of remimazolam besylate and propofol for deep sedation in critically ill patients. In t...
Combination of serum and peritoneal 1.3-beta-d-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study
Combination of serum and peritoneal 1.3-beta-d-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study
Intra-abdominal candidiasis (IAC) is difficult to predict in critically ill patients with intra-abdominal infection, leadi...
Publisher Correction to: Critical Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long‑term outcomes
Publisher Correction to: Critical Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long‑term outcomes
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Prognostic differences in sepsis caused by gram-negative bacteria and gram-positive bacteria: a systematic review and meta-analysis
Prognostic differences in sepsis caused by gram-negative bacteria and gram-positive bacteria: a systematic review and meta-analysis
Bacteria are the main pathogens that cause sepsis. The pathogenic mechanisms of sepsis caused by gram-negative and gram-po...
Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials
Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials
To evaluate the potential association between early dysnatremia and 6-month functional outcome after cardiac arrest. We po...
Effects of lower versus higher oxygen targets on out-of-hospital cardiac arrest
Effects of lower versus higher oxygen targets on out-of-hospital cardiac arrest
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review
Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review
It is unclear how often survival benefits observed in single-center randomized controlled trials (sRCTs) involving critica...
Response to comment on human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
Response to comment on human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
Unterberg M, Ehrentraut SF, Bracht T, Wolf A, Haberl H, von Busch A, Rump K, Ziehe D, Bazzi M, Thon P, et al. Human cytome...
External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock
External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock
Acute kidney injury (AKI) occurs commonly in pediatric septic shock and increases morbidity and mortality. Early identific...
Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy
Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy
Monitoring respiratory effort in ventilated patients is important to balance lung and diaphragm protection. Esophageal man...
Effects of early versus delayed application of prone position on ventilation–perfusion mismatch in patients with acute respiratory distress syndrome: a prospective observational study
Effects of early versus delayed application of prone position on ventilation–perfusion mismatch in patients with acute respiratory distress syndrome: a prospective observational study
Prone position has been shown to improve oxygenation and survival in patients with early acute respiratory distress syndro...
Extending the ‘host response’ paradigm from sepsis to cardiogenic shock: evidence, limitations and opportunities
Extending the ‘host response’ paradigm from sepsis to cardiogenic shock: evidence, limitations and opportunities
Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the restoration of the low cardiac...
Evaluation of the sensory environment in a large tertiary ICU
Evaluation of the sensory environment in a large tertiary ICU
ICU survival is improving. However, many patients leave ICU with ongoing cognitive, physical, and/or psychological impairm...
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