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The combination of ropeginterferon alfa-2b with anti-PD1 blockage in adjuvant therapy in HBV-related HCC
The combination of ropeginterferon alfa-2b with anti-PD1 blockage in adjuvant therapy in HBV-related HCC
Authors and AffiliationsMedical Research and Clinical Operations, PharmaEssentia Corporation, Taipei, TaiwanAlbert Qin &am...
Recombinant albumin in cirrhosis: can this be a reality?
Recombinant albumin in cirrhosis: can this be a reality?
In this issue of Hepatology International, Wang et al. conducted a randomized, open-label, early-phase ‘proof of concept’ ...
Small extracellular vesicles derived from lipotoxic hepatocytes transport FASN to promote hepatic stellate cell activation
Small extracellular vesicles derived from lipotoxic hepatocytes transport FASN to promote hepatic stellate cell activation
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease worldwide, ...
Machine learning prediction of rapid HBsAg seroclearance at week 24 in inactive carriers treated with pegylated interferon
Machine learning prediction of rapid HBsAg seroclearance at week 24 in inactive carriers treated with pegylated interferon
To identify predictive factors for rapid hepatitis B surface antigen (HBsAg) seroclearance at week 24 in inactive HBsAg ca...
Inhibition of the U12-type splicing factor ZCRB1 mediates retention of the USP21 minor intron to suppress malignant progression in hepatocellular carcinoma
Inhibition of the U12-type splicing factor ZCRB1 mediates retention of the USP21 minor intron to suppress malignant progression in hepatocellular carcinoma
RNA splicing dysregulation plays an important role in hepatocellular carcinoma (HCC). However, the critical functions of z...
Enhancing post-TIPS hepatic encephalopathy risk stratification: a hybrid TabPFN model leveraging radiomics, deep transfer learning features, and MELD score
Enhancing post-TIPS hepatic encephalopathy risk stratification: a hybrid TabPFN model leveraging radiomics, deep transfer learning features, and MELD score
Predicting hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) is critical for guiding ...
Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease
Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease
The proportion of non-B/non-C hepatocellular carcinoma cases is increasing, and the principal cause is metabolic dysfuncti...
Global prevalence, metabolic characteristics, and outcomes of lean-MAFLD: a systematic review and meta-analysis
Global prevalence, metabolic characteristics, and outcomes of lean-MAFLD: a systematic review and meta-analysis
Metabolic Dysfunction-Associated Fatty Liver disease (MAFLD) among lean individuals is increasingly recognized. We aimed t...
Explainable attention-enhanced heuristic paradigm for multi-view prognostic risk score development in hepatocellular carcinoma
Explainable attention-enhanced heuristic paradigm for multi-view prognostic risk score development in hepatocellular carcinoma
Existing prognostic staging systems depend on expensive manual extraction by pathologists, potentially overlooking latent ...
Systemic inflammatory response markers improve the discrimination for prognostic model in hepatocellular carcinoma
Systemic inflammatory response markers improve the discrimination for prognostic model in hepatocellular carcinoma
We aimed to evaluate the performance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and thei...
The promise of incretin-based pharmacotherapies for metabolic dysfunction-associated fatty liver disease
The promise of incretin-based pharmacotherapies for metabolic dysfunction-associated fatty liver disease
The presence of excess liver fat secondary to metabolic dysregulation represents the end-organ manifestation of a systemic...
Efficacy and safety of radiotherapy versus transarterial chemoembolization in combination with lenvatinib and camrelizumab for hepatocellular carcinoma with inferior vena cava/right atrium tumor thrombus: a multicenter study
Efficacy and safety of radiotherapy versus transarterial chemoembolization in combination with lenvatinib and camrelizumab for hepatocellular carcinoma with inferior vena cava/right atrium tumor thrombus: a multicenter study
This study aims to compare the efficacy and safety of radiotherapy (RT) and transarterial chemoembolization (TACE) in hepa...
Correction: Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation
Correction: Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Risk stratification for patients with primary biliary cholangitis: early versus advanced-stage or non-cirrhosis versus cirrhosis?
Risk stratification for patients with primary biliary cholangitis: early versus advanced-stage or non-cirrhosis versus cirrhosis?
Primary biliary cholangitis (PBC) is divided into early and advanced stages, which are two distinct disease states, and wh...
Platelet slope and long-term clinical outcomes in children and adults with Fontan-associated liver disease
Platelet slope and long-term clinical outcomes in children and adults with Fontan-associated liver disease
There is a lack of robust literature describing a relationship between platelet count as a reflection of liver fibrosis an...
Breaking bottlenecks: the future of hepatocellular carcinoma clinical trials and therapeutic targets
Breaking bottlenecks: the future of hepatocellular carcinoma clinical trials and therapeutic targets
To provide a reference for hepatocellular carcinoma (HCC) clinical trials, we analyzed HCC clinical trials and therapeutic...
Reply to “Metabolic (dysfunction)-associated fatty liver disease metrics and contributions: Correspondence”
Reply to “Metabolic (dysfunction)-associated fatty liver disease metrics and contributions: Correspondence”
SE, ME, and JG are supported by the Robert W. Storr Bequest to the Sydney Medical Foundation, The University of Sydney; a ...
Carvedilol and traditional nonselective beta blockers for the secondary prophylaxis of variceal hemorrhage and portal hypertension related complications among patients with decompensated cirrhosis: a systematic review and network meta-analysis
Carvedilol and traditional nonselective beta blockers for the secondary prophylaxis of variceal hemorrhage and portal hypertension related complications among patients with decompensated cirrhosis: a systematic review and network meta-analysis
Carvedilol has limited research on decompensated cirrhosis. This study compared the effects of carvedilol, traditional non...
Model of baseline clinicopathological features predicts non-resolution of drug-induced liver injury at 6 months
Model of baseline clinicopathological features predicts non-resolution of drug-induced liver injury at 6 months
Chronicity in drug-induced liver injury (DILI) is assessed at 12 months, leading to a large time gap from its ini...
The interplay between lymphatic system and portal hypertension: a comprehensive review
The interplay between lymphatic system and portal hypertension: a comprehensive review
The pathophysiology of portal hypertension revolves around numerous structural and functional changes in the intr...
Estimates of the global prevalence of occult hepatitis B virus infection in population under 18 years old: a systematic review and meta-analysis
Estimates of the global prevalence of occult hepatitis B virus infection in population under 18 years old: a systematic review and meta-analysis
Occult hepatitis B virus infection (OBI) is defined by the presence of hepatitis B virus (HBV) DNA, while HBsAg (...
Sequential combination with ropeginterferon alfa-2b and anti-PD-1 treatment as adjuvant therapy in HBV-related HCC: a phase 1 dose escalation trial
Sequential combination with ropeginterferon alfa-2b and anti-PD-1 treatment as adjuvant therapy in HBV-related HCC: a phase 1 dose escalation trial
Post-operative recurrence is a major clinical challenge with hepatocellular carcinoma (HCC). While currently unapproved, a...
Mindin orchestrates the macrophage-mediated resolution of liver fibrosis in mice
Mindin orchestrates the macrophage-mediated resolution of liver fibrosis in mice
Liver disease that progresses to cirrhosis is an enormous health problem worldwide. The extracellular matrix protein Mindi...
Diverse approaches and sources to derive antitumor T cell for liver cancer: a single-cell sequence based research
Diverse approaches and sources to derive antitumor T cell for liver cancer: a single-cell sequence based research
Despite advancements in adoptive cell therapy (ACT) for hematologic tumors, its role in solid tumors still lacks satisfact...
Incidence and predictors of hepatocellular carcinoma in NAFLD without diagnosed cirrhosis: a nationwide real-world U.S. study
Incidence and predictors of hepatocellular carcinoma in NAFLD without diagnosed cirrhosis: a nationwide real-world U.S. study
A substantial proportion of patients with nonalcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC) ...
Recompensation in treatment-naïve HBV-related decompensated cirrhosis: a 5-year multi-center observational study comparing patients with ascites and bleeding
Recompensation in treatment-naïve HBV-related decompensated cirrhosis: a 5-year multi-center observational study comparing patients with ascites and bleeding
Recompensation between patients with ascites and bleeding was unknown in treatment-naïve HBV-related decompensated ci...
How non-alcoholic fatty liver disease and cirrhosis affect the heart
How non-alcoholic fatty liver disease and cirrhosis affect the heart
Liver diseases affect the heart and the vascular system. Cardiovascular complications appear to be a leading cause of deat...
Ending stigmatizing language in alcohol and liver disease: a liver societies’ statement
Ending stigmatizing language in alcohol and liver disease: a liver societies’ statement
Authors and AffiliationsConsortiaEuropean Association for the Study of the LiverAmerican Association for the Study of Live...
Serial circulating tumor DNA profiling predicts tumor recurrence after liver transplantation for liver cancer
Serial circulating tumor DNA profiling predicts tumor recurrence after liver transplantation for liver cancer
Minimal residual disease (MRD) is proposed to be responsible for tumor recurrence. The role of circulating tumor DNA (ctDN...
Why is the functional cure rate of young children with chronic hepatitis B receiving antiviral therapy considerably high?
Why is the functional cure rate of young children with chronic hepatitis B receiving antiviral therapy considerably high?
Terrault NA, Lok AS, McMahon BJ, Chang KM, Hwang JP, Jonas MM, et al. Update on prevention, diagnosis, and treatment of ch...
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