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Prolactin acts on proopiomelanocortin neurons to regulate hepatic lipid metabolism
Prolactin acts on proopiomelanocortin neurons to regulate hepatic lipid metabolism
To elucidate the central mechanism of pituitary-derived prolactin (PRL) in hepatic lipid homeostasis and identify therapeu...
Obstructive sleep apnea mediates the association between body mass index and metabolic dysfunction-associated steatotic liver disease in patients with obesity
Obstructive sleep apnea mediates the association between body mass index and metabolic dysfunction-associated steatotic liver disease in patients with obesity
Obstructive sleep apnea (OSA) and metabolic dysfunction-associated steatotic liver disease (MASLD) are frequently encounte...
Suppression of macrophage membrane cholesterol efflux by SLAMF7-induced IL-7 signaling improves immunotherapy efficacy in hepatocellular carcinoma
Suppression of macrophage membrane cholesterol efflux by SLAMF7-induced IL-7 signaling improves immunotherapy efficacy in hepatocellular carcinoma
The limited efficacy of immunotherapy in hepatocellular carcinoma (HCC) is largely attributed to the formation of an immun...
Global trends in metabolic-associated hepatocellular carcinoma: genetic and socio-demographic drivers
Global trends in metabolic-associated hepatocellular carcinoma: genetic and socio-demographic drivers
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a primary driver of hepatocellular carcino...
Identifying a biologically high-risk subgroup of anatomically resectable hepatocellular carcinoma
Identifying a biologically high-risk subgroup of anatomically resectable hepatocellular carcinoma
Although anatomically resectable hepatocellular carcinoma (HCC) is generally treated with surgery alone, a substantial pro...
Effect of testosterone addition to nutrition and exercise on muscle mass in men with cirrhosis: the next trial
Effect of testosterone addition to nutrition and exercise on muscle mass in men with cirrhosis: the next trial
Nutrition supplementation and exercise are the current approaches for managing sarcopenia in patients with cirrhosis. Ther...
Alcohol consumption and dementia risk in steatotic liver disease: a nationwide cohort study
Alcohol consumption and dementia risk in steatotic liver disease: a nationwide cohort study
The relationship between steatotic liver disease (SLD) and dementia remains unclear, particularly regarding alcohol consum...
Spatial analysis identifies overexpression in hepatocellular carcinoma with vessels encapsulating tumor clusters
Spatial analysis identifies overexpression in hepatocellular carcinoma with vessels encapsulating tumor clusters
Vessels encapsulating tumor clusters (VETC) is a distinct angiogenic pattern in hepatocellular carcinoma (HCC). While VETC...
Trends in MASLD-related cirrhosis and liver cancer across diverse populations, 2010–2023
Trends in MASLD-related cirrhosis and liver cancer across diverse populations, 2010–2023
Metabolic dysfunction-associated steatotic liver disease (MASLD) is now a leading cause of liver complications. This study...
Efficacy of radiation therapy plus targeted therapy with or without immunotherapy for lymph node metastases in hepatocellular carcinoma
Efficacy of radiation therapy plus targeted therapy with or without immunotherapy for lymph node metastases in hepatocellular carcinoma
This study aimed to investigate the efficacy of radiation therapy and targeted therapy combined with or without immunother...
APASL clinical practice guidelines on the management of chronic hepatitis B infection: a 2026 update
APASL clinical practice guidelines on the management of chronic hepatitis B infection: a 2026 update
Globally, especially in the Asia Pacific region, chronic hepatitis B infection has led to an undesirable escalating morbid...
Pathological transcriptional retention of in perirenal adipose-derived stem cells contributes to MASLD progression
Pathological transcriptional retention of in perirenal adipose-derived stem cells contributes to MASLD progression
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disorder linked to metabolic syndrom...
APASL clinical practice guidance: the diagnosis and management of patients with Wilson’s disease
APASL clinical practice guidance: the diagnosis and management of patients with Wilson’s disease
Czlonkowska A, Litwin T, Dusek P, Ferenci P, Lutsenko S, Medici V, et al. Wilson disease. Nat Rev Dis Primers. 2018;4(1):2...
Efficacy of tirzepatide versus SGLT2 inhibitors in metabolic dysfunction-associated steatotic liver disease (MASLD): a multicenter propensity-matched real-world study
Efficacy of tirzepatide versus SGLT2 inhibitors in metabolic dysfunction-associated steatotic liver disease (MASLD): a multicenter propensity-matched real-world study
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent condition with significant cardiometabolic...
Prevalence and associated factors of metabolic dysfunction-associated steatotic liver disease in Taiwan, 2001–2021
Prevalence and associated factors of metabolic dysfunction-associated steatotic liver disease in Taiwan, 2001–2021
Metabolic dysfunction-associated steatotic liver disease (MASLD) was the most rapidly growing liver disease worldwide. We ...
Circulating cfDNA CD86 methylation is associated with durable response to atezolizumab–bevacizumab in hepatocellular carcinoma
Circulating cfDNA CD86 methylation is associated with durable response to atezolizumab–bevacizumab in hepatocellular carcinoma
/purpose. Although atezolizumab–bevacizumab is approved for unresectable hepatocellular carcinoma (HCC), only a subs...
New oral anticoagulants and hepatocellular carcinoma among patients with HBV, HCV, and alcoholic liver diseases: a nationwide cohort study
New oral anticoagulants and hepatocellular carcinoma among patients with HBV, HCV, and alcoholic liver diseases: a nationwide cohort study
Coagulation pathways are increasingly recognized as an influencer of tumor development. Experimental evidence suggests tha...
Neutrophil extracellular traps drive cholangiocyte injury via ZNF709–TP53–MDM2 pathway in primary biliary cholangitis
Neutrophil extracellular traps drive cholangiocyte injury via ZNF709–TP53–MDM2 pathway in primary biliary cholangitis
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease in which many patients respond inadequately to urs...
The combination of ropeginterferon alfa-2b with anti-PD1 blockage in adjuvant therapy in HBV-related HCC
The combination of ropeginterferon alfa-2b with anti-PD1 blockage in adjuvant therapy in HBV-related HCC
Authors and AffiliationsMedical Research and Clinical Operations, PharmaEssentia Corporation, Taipei, TaiwanAlbert Qin &am...
Recombinant albumin in cirrhosis: can this be a reality?
Recombinant albumin in cirrhosis: can this be a reality?
In this issue of Hepatology International, Wang et al. conducted a randomized, open-label, early-phase ‘proof of concept’ ...
Small extracellular vesicles derived from lipotoxic hepatocytes transport FASN to promote hepatic stellate cell activation
Small extracellular vesicles derived from lipotoxic hepatocytes transport FASN to promote hepatic stellate cell activation
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease worldwide, ...
Machine learning prediction of rapid HBsAg seroclearance at week 24 in inactive carriers treated with pegylated interferon
Machine learning prediction of rapid HBsAg seroclearance at week 24 in inactive carriers treated with pegylated interferon
To identify predictive factors for rapid hepatitis B surface antigen (HBsAg) seroclearance at week 24 in inactive HBsAg ca...
Inhibition of the U12-type splicing factor ZCRB1 mediates retention of the USP21 minor intron to suppress malignant progression in hepatocellular carcinoma
Inhibition of the U12-type splicing factor ZCRB1 mediates retention of the USP21 minor intron to suppress malignant progression in hepatocellular carcinoma
RNA splicing dysregulation plays an important role in hepatocellular carcinoma (HCC). However, the critical functions of z...
Enhancing post-TIPS hepatic encephalopathy risk stratification: a hybrid TabPFN model leveraging radiomics, deep transfer learning features, and MELD score
Enhancing post-TIPS hepatic encephalopathy risk stratification: a hybrid TabPFN model leveraging radiomics, deep transfer learning features, and MELD score
Predicting hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) is critical for guiding ...
Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease
Efficacy of measuring natural killer-activating receptor ligands to predict the pathogenesis of metabolic dysfunction-associated steatotic liver disease
The proportion of non-B/non-C hepatocellular carcinoma cases is increasing, and the principal cause is metabolic dysfuncti...
Global prevalence, metabolic characteristics, and outcomes of lean-MAFLD: a systematic review and meta-analysis
Global prevalence, metabolic characteristics, and outcomes of lean-MAFLD: a systematic review and meta-analysis
Metabolic Dysfunction-Associated Fatty Liver disease (MAFLD) among lean individuals is increasingly recognized. We aimed t...
Explainable attention-enhanced heuristic paradigm for multi-view prognostic risk score development in hepatocellular carcinoma
Explainable attention-enhanced heuristic paradigm for multi-view prognostic risk score development in hepatocellular carcinoma
Existing prognostic staging systems depend on expensive manual extraction by pathologists, potentially overlooking latent ...
Systemic inflammatory response markers improve the discrimination for prognostic model in hepatocellular carcinoma
Systemic inflammatory response markers improve the discrimination for prognostic model in hepatocellular carcinoma
We aimed to evaluate the performance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and thei...
The promise of incretin-based pharmacotherapies for metabolic dysfunction-associated fatty liver disease
The promise of incretin-based pharmacotherapies for metabolic dysfunction-associated fatty liver disease
The presence of excess liver fat secondary to metabolic dysregulation represents the end-organ manifestation of a systemic...
Efficacy and safety of radiotherapy versus transarterial chemoembolization in combination with lenvatinib and camrelizumab for hepatocellular carcinoma with inferior vena cava/right atrium tumor thrombus: a multicenter study
Efficacy and safety of radiotherapy versus transarterial chemoembolization in combination with lenvatinib and camrelizumab for hepatocellular carcinoma with inferior vena cava/right atrium tumor thrombus: a multicenter study
This study aims to compare the efficacy and safety of radiotherapy (RT) and transarterial chemoembolization (TACE) in hepa...
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