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Winners of Lasker Foundation Video Contest announced
Published in Volume 136, Issue 14 on July 15, 2026 J Clin Invest. 2026;136(14):e210286. https://doi.org/10.1172/JCI210...
Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes
Research ArticleClinical ResearchGeneticsOncology Open Access | 10.1172/JCI204429 Mona Arabza...
Single-cell analysis of fetal testis reveals dysfunction of human Leydig cells in Klinefelter syndrome
Research ArticleCell biologyReproductive biology Open Access | 10.1172/JCI201124 Tong Yan,1 ...
SIRT2-mediated deacetylation activates USP22 catalytic function for PD-L1 protein stabilization and tumor immune escape
Identification of SIRT2 as a positive regulator to control PD-L1 protein expression in cancer cells at the posttranscript...
CXCR6+ CD127– Tr1 cells balance immunity and persistence in Plasmodium falciparum infection
Research ArticleImmunologyInfectious disease Open Access | 10.1172/JCI200628 Jason Nideffer,1...
Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype
Clinical Research and Public HealthClinical ResearchImmunologyInflammation Open Access | 10.1172/JCI202867 ...
Gut microbe–derived short-chain fatty acids regulate alphavirus arthritis and macrophage activation in mice
Research ArticleImmunologyInfectious diseaseMicrobiology Open Access | 10.1172/JCI202262 Fang...
Sterol biosynthesis, brain development, and disease
The work described here firmly establishes the critical requirement for cholesterol biosynthesis during brain development...
Pathological disruption of CELF2 shuttling causes neuronal hyperactivity, learning deficits, and seizures
Research ArticleClinical ResearchDevelopmentGenetics Open Access | 10.1172/JCI199698 Michelle...
Antigen-specific type 1 regulatory T cell responses shape immunity and disease tolerance in human malaria
In this issue, Nideffer et al. (15) define the functional role of human Tr1 cells during pediatric Plasmodium falciparum ...
TGF-β signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration
Loss of PGRN leads to aberrant growth in cortical organoids. To determine how PGRN deficiency might impact neurodevelopme...
The bone-cerebrovascular axis: effects of bone aging on neurovascular dysfunction and neurodegeneration
Age-related changes in bone. The skeletal system is a dynamic structure that undergoes continuous remodeling (100), which...
Fumarate-induced succination of A-kinase anchor protein 12 exacerbates renal inflammation and fibrosis
Research ArticleInflammationMetabolismNephrology Open Access | 10.1172/JCI200755 Shuai Sun,1,...
Osteopontin mediates acquired resistance to hypoxia-inducing antiangiogenics and promotes anti–PD-L1 refractoriness in breast cancer models
Hypoxia-inducing antiangiogenic treatment upregulates the PD-1/PD-L1 axis, but blocking it in this context lacks efficacy...
Therapy-resistant lymphomas may want nucleotides, but they just need to grow
When Jagger and Richards wrote the lines “You can’t always get what you want, but if you try sometime…you get what you ne...
SLC15A3-mediated dipeptide metabolism confers antimetabolite resistance in lymphoma via mTORC1 activation
Research ArticleHematologyMetabolismOncology Open Access | 10.1172/JCI199709 Haojun Yang,1,2,...
SEC16B identified as a regulator of VLDL secretion and lipid accumulation in the liver
Lu and colleagues identified SEC16B as a regulator of both VLDL and LD metabolism (5). Previous GWAS identified an associ...
Hepatic SEC16B regulates lipid homeostasis by coordinating VLDL secretion and lipid droplet expansion
SNP in SEC16B is associated with plasma cholesterol levels in humans. GWAS has identified that 1 of the SNPs (rs6682862, ...
The perinecrotic niche of glioblastoma drives tumor-associated macrophage polarization and immunosuppression via podoplanin-mediated CLEC5A activation
CLEC5A expression by TAM-IM is a strong predictor of poor clinical outcomes. To characterize TME profiles of IDH-WT GBM a...
Virus-associated inflammation imprints an inflammatory profile on monocyte-derived macrophages in the human liver
Research ArticleHepatologyImmunologyInfectious disease Open Access | 10.1172/JCI175241 Juan D...
Cell-intrinsic insulin signaling defects in human iPS cell–derived hepatocytes in type 2 diabetes
Directed differentiation of patient-derived inducible hepatocytes. To identify cell-intrinsic determinants of insulin res...
Identification of potent biparatopic antibodies targeting FGFR2 fusion–driven cholangiocarcinoma
The extracellular domain is necessary for full transformation by FGFR2 fusions. To ascertain the role of FGFR2-fusion ECD...
Addiction of primary cutaneous γδ T cell lymphomas to JAK/STAT signaling
Research LetterDermatologyOncology Open Access | 10.1172/JCI180417 Yue Zhang,1,2 Julia A....
Reduced EIF6 dosage attenuates TP53 activation in models of Shwachman-Diamond syndrome
EIF6 accumulates in the cells of patients with SDS and sbds-null zebrafish. Somatic mutations in EIF6 or its haploinsuffi...
Clinical evidence for independent regulation of vitamin D by intestinal CYP24A1
Letter to the EditorGeneticsNephrology Open Access | 10.1172/JCI190972 Sandrine Lemoine,1,2 ...
Clinical evidence for independent regulation of vitamin D by intestinal CYP24A1. Reply.
1Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.2Joan ...
Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models
Research ArticleDevelopmentNeuroscience Open Access | 10.1172/JCI176631 Minkyung Kang,1,2 ...
A dominant-negative IFNGR1 variant reveals broad immune cell sequestering of IFN-γ
Research LetterGeneticsImmunology Open Access | 10.1172/JCI186799 Samantha Chan,1,2,3,4,5 ...
SLAMF7 and SLAMF8 receptors shape human plasmacytoid dendritic cell responses to intracellular bacteria
Human blood transcriptomic signatures reveal changes in SLAMF7 and SLAMF8 expression levels in a large panel of infectiou...
STK4 regulates TLR pathways and protects against chronic inflammation–related hepatocellular carcinoma
Published in Volume 135, Issue 8 on April 15, 2025 J Clin Invest. 2025;135(8):e193453. https://doi.org/10.1172/JCI1934...
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