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Virus-associated inflammation imprints an inflammatory profile on monocyte-derived macrophages in the human liver
Research ArticleHepatologyImmunologyInfectious disease Open Access | 10.1172/JCI175241 Juan D...
Cell-intrinsic insulin signaling defects in human iPS cell–derived hepatocytes in type 2 diabetes
Directed differentiation of patient-derived inducible hepatocytes. To identify cell-intrinsic determinants of insulin res...
Identification of potent biparatopic antibodies targeting FGFR2 fusion–driven cholangiocarcinoma
The extracellular domain is necessary for full transformation by FGFR2 fusions. To ascertain the role of FGFR2-fusion ECD...
Addiction of primary cutaneous γδ T cell lymphomas to JAK/STAT signaling
Research LetterDermatologyOncology Open Access | 10.1172/JCI180417 Yue Zhang,1,2 Julia A....
Reduced EIF6 dosage attenuates TP53 activation in models of Shwachman-Diamond syndrome
EIF6 accumulates in the cells of patients with SDS and sbds-null zebrafish. Somatic mutations in EIF6 or its haploinsuffi...
Clinical evidence for independent regulation of vitamin D by intestinal CYP24A1
Letter to the EditorGeneticsNephrology Open Access | 10.1172/JCI190972 Sandrine Lemoine,1,2 ...
Clinical evidence for independent regulation of vitamin D by intestinal CYP24A1. Reply.
1Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.2Joan ...
Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models
Research ArticleDevelopmentNeuroscience Open Access | 10.1172/JCI176631 Minkyung Kang,1,2 ...
A dominant-negative IFNGR1 variant reveals broad immune cell sequestering of IFN-γ
Research LetterGeneticsImmunology Open Access | 10.1172/JCI186799 Samantha Chan,1,2,3,4,5 ...
SLAMF7 and SLAMF8 receptors shape human plasmacytoid dendritic cell responses to intracellular bacteria
Human blood transcriptomic signatures reveal changes in SLAMF7 and SLAMF8 expression levels in a large panel of infectiou...
STK4 regulates TLR pathways and protects against chronic inflammation–related hepatocellular carcinoma
Published in Volume 135, Issue 8 on April 15, 2025 J Clin Invest. 2025;135(8):e193453. https://doi.org/10.1172/JCI1934...
Transient pain and long-term gain: adjuvant dose directs immune memory
The immune system distinguishes self from non-self with remarkable precision, even down to single amino acids; but peptid...
The saponin monophosphoryl lipid A nanoparticle adjuvant induces dose-dependent HIV vaccine responses in nonhuman primates
Research ArticleAIDS/HIVImmunology Open Access | 10.1172/JCI185292 Parham Ramezani-Rad,1,2 ...
Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling
Research ArticleCell biologyImmunology Open Access | 10.1172/JCI186648 Wenjie Wei,1,2,3 H...
An inherited predisposition allele promotes gastric cancer via enhancing deubiquitination-mediated activation of epithelial-to-mesenchymal transition signaling
Research ArticleGeneticsOncology Open Access | 10.1172/JCI179617 Bolin Tao,1 Zhenning Wan...
Developing cell-based therapies for pancreatic ductal adenocarcinoma
Characterized by its dense desmoplasia, the PDAC tumor microenvironment (TME) is highly immunosuppressive. Largely orches...
Off-the-shelf invariant NKT cells expressing anti-PSCA CAR and IL-15 promote pancreatic cancer regression in mice
Research ArticleImmunologyOncology Open Access | 10.1172/JCI179014 Zhenyu Dai,1 Zheng Zhu...
Sequential carbonyl derivatives and hydrazone adduct formation on myeloperoxidase contribute to development of ANCA vasculitis
Research Article Open Access | 10.1172/JCI178813 Gang Xi,1 Elizabeth A. Mclnnis,1 Oli...
Megakaryocytes transfer mitochondria to bone marrow mesenchymal stromal cells to lower platelet activation
Research ArticleHematology Open Access | 10.1172/JCI189801 Chengjie Gao,1 Yitian Dai,2 ...
CRISPR-mediated detection of Pneumocystis transcripts in bronchoalveolar, oropharyngeal, and serum specimens for Pneumocystis pneumonia diagnosis
Clinical Research and Public HealthInfectious diseasePulmonology Open Access | 10.1172/JCI177241 ...
Hepatitis B virus infection disrupts homologous recombination in hepatocellular carcinoma by stabilizing resection inhibitor ADRM1
Research ArticleHepatologyVirology Open Access | 10.1172/JCI171533 Ming Zeng,1 Zizhi Tang,1...
Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis
Research ArticleDermatologyImmunology Open Access | 10.1172/JCI171088 Satoshi Nakamizo,1,2 ...
Bone-derived PDGF-BB drives brain vascular calcification in male mice
Aged mice develop brain calcification primarily in the thalamus region. Brain calcification is commonly detected in elder...
OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity
Research ArticleDevelopmentReproductive biology Open Access | 10.1172/JCI161701 Adriana Lofrano...
Does activating brown fat contribute to important metabolic benefits in humans? Yes!
Research on mouse FA metabolism has shown how triglyceride-rich lipoproteins (TRL) are taken up through a sequence of tis...
High-frequency home self-collection of capillary blood correlates IFI27 expression kinetics with SARS-CoV-2 viral clearance
Research LetterCOVID-19Infectious disease Open Access | 10.1172/JCI173715 Fang Yun Lim,1,2 ...
A splice-switching oligonucleotide treatment ameliorates glycogen storage disease type 1a in mice with G6PC c.648G>T
Research ArticleMetabolismTherapeutics Open Access | 10.1172/JCI163464 Kentaro Ito,1,2 Go T...
Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses
Research ArticleVaccines Open Access | 10.1172/JCI166827 Atsushi Kawai,1,2 Nagisa Tokunoh,2...
Microenvironmental network of clonal CXCL13+CD4+ T cells and Tregs in pemphigus chronic blisters
Clinical MedicineAutoimmunityDermatology Open Access | 10.1172/JCI166357 Dawoon Han,1 A Yeo...
The gift of preexisting immunity for developing an alternative vaccine strategy
The SARS-CoV-2 pandemic brought an immense advancement in vaccine development, resulting in the worldwide distribution of...
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