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MELK study: an observational study on human milk composition and infant health determinants during the first year of life in a Dutch cohort
MELK study: an observational study on human milk composition and infant health determinants during the first year of life in a Dutch cohort
IntroductionHuman milk, together with recommended supplementations of vitamins D and K,1 is the most complete and healthie...
Interhospital transports and mortality in patients with critical COVID-19: a single-centre cohort study
Interhospital transports and mortality in patients with critical COVID-19: a single-centre cohort study
STRENGTHS AND LIMITATIONS OF THIS STUDYThe strengths are the comprehensive data collection conducted by dedicated research...
Determinants of unfavourable treatment outcomes of drug-resistant tuberculosis cases in Malaysia: a case-control study
Determinants of unfavourable treatment outcomes of drug-resistant tuberculosis cases in Malaysia: a case-control study
STRENGTHS AND LIMITATIONS OF THIS STUDYThe retrospective case–control design allows the examination of multiple exposures ...
Prevalence of pulmonary dysfunction and its risk factors in patients with transfusion-dependent thalassaemia: protocol for a systematic review and meta-analysis
Prevalence of pulmonary dysfunction and its risk factors in patients with transfusion-dependent thalassaemia: protocol for a systematic review and meta-analysis
We will search PubMed, EMBASE, the Cochrane Library, Scopus and Web of Science to identify English-language literature fro...
Cost-effectiveness analysis of daratumumab plus bortezomib, melphalan and prednisone versus bortezomib, melphalan and prednisone in patients with newly diagnosed multiple myeloma ineligible for stem cell transplantation
Cost-effectiveness analysis of daratumumab plus bortezomib, melphalan and prednisone versus bortezomib, melphalan and prednisone in patients with newly diagnosed multiple myeloma ineligible for stem cell transplantation
IntroductionMultiple myeloma (MM), which is characterised by a clonal proliferation of plasma cells in the bone marrow, is...
Is geographical variation in emergency epilepsy admissions related to variation in new epilepsy diagnoses among children and young people across England? An observational study using linked datasets
Is geographical variation in emergency epilepsy admissions related to variation in new epilepsy diagnoses among children and young people across England? An observational study using linked datasets
STRENGTHS AND LIMITATIONS OF THIS STUDYWe use methodology for specifically estimating paediatric hospital catchment popula...
Exploring barriers, motivators and facilitators for physical activity and exercise in a UK South Asian community: a qualitative study
Exploring barriers, motivators and facilitators for physical activity and exercise in a UK South Asian community: a qualitative study
STRENGTHS AND LIMITATIONS OF THIS STUDYThis research was completed in accordance with the consolidated criteria (Consolida...
Association between physical activity and diabetes mellitus: mediation analysis involving Systemic Immune-Inflammatory Index in a cross-sectional NHANES study
Association between physical activity and diabetes mellitus: mediation analysis involving Systemic Immune-Inflammatory Index in a cross-sectional NHANES study
Strengths and limitations of this studyThis study used a large and nationally representative sample of the American adult ...
Satisfaction with HIV/AIDS treatment and care services and its associated factors among adult people receiving antiretroviral therapy in Ethiopia: a systematic review and meta-analysis
Satisfaction with HIV/AIDS treatment and care services and its associated factors among adult people receiving antiretroviral therapy in Ethiopia: a systematic review and meta-analysis
STRENGTHS AND LIMITATIONS OF THIS STUDYThis systematic review and meta-analysis was registered in the International Prospe...
Climate footprint of industry-sponsored in-human clinical trials: life cycle assessments of clinical trials spanning multiple phases and disease areas
Climate footprint of industry-sponsored in-human clinical trials: life cycle assessments of clinical trials spanning multiple phases and disease areas
STRENGTHS AND LIMITATIONS OF THIS STUDYThis is the first study comparing greenhouse gas (GHG) emissions from industry-spon...
Effectiveness and influencing factors of standardised training for nursing assistants: a cross-sectional study
Effectiveness and influencing factors of standardised training for nursing assistants: a cross-sectional study
STRENGTHS AND LIMITATIONS OF THIS STUDYResearch focuses on the motivational factors and barriers that influence the partic...
Exploring the value Australian community leaders see in a system dynamics model calibrated with local data: social norms and childhood obesity
Exploring the value Australian community leaders see in a system dynamics model calibrated with local data: social norms and childhood obesity
STRENGTHS AND LIMITATIONS OF THIS STUDYThis study unites three novel scientific contributions in the realm of systems appr...
Efficacy of psychotherapy versus pharmacotherapy, or their combination, in chronic depression: study protocol for a systematic review and network meta-analysis using aggregated and individual patient data
Efficacy of psychotherapy versus pharmacotherapy, or their combination, in chronic depression: study protocol for a systematic review and network meta-analysis using aggregated and individual patient data
Eligibility criteriaWe will include data from RCTs that investigated treatment effects in adult (>18 years old) inpatie...
Quantitative CT imaging characteristics of patients with chronic obstructive pulmonary disease with different eosinophil levels: a retrospective observational study using linked data from a tertiary hospital in China
Quantitative CT imaging characteristics of patients with chronic obstructive pulmonary disease with different eosinophil levels: a retrospective observational study using linked data from a tertiary hospital in China
IntroductionChronic obstructive pulmonary disease (COPD) is a prevalent chronic airway inflammatory condition characterise...
Contemporary European practice in left atrial appendage closure: results from a survey focusing on planning, techniques and post-implantation management
Contemporary European practice in left atrial appendage closure: results from a survey focusing on planning, techniques and post-implantation management
IntroductionGrowing evidence supports left atrial appendage closure (LAAC) for stroke prevention in patients with non-valv...
Can behavioural science be used to understand factors that influence the prescription choice for Parkinsons disease? A pan-European focus group study of clinicians prescribing practice
Can behavioural science be used to understand factors that influence the prescription choice for Parkinsons disease? A pan-European focus group study of clinicians prescribing practice
Strengths and limitations of this studyParticipants were recruited from across Europe, thereby gathering insights from a r...
Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis
Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis
Background‘Tackling climate change could be the greatest global health opportunity of the 21st century.’1 Through comprehe...
Telephonic verbal autopsies among adults in South Africa: a feasibility and acceptability pilot study
Telephonic verbal autopsies among adults in South Africa: a feasibility and acceptability pilot study
STRENGTHS AND LIMITATIONS OF THIS STUDYThis study is among the first to evaluate telephonic verbal autopsy (teleVA) as an ...
Isokinetic muscle strength training combined with proprioceptive neuromuscular facilitation for rehabilitation of patients after anterior cruciate ligament reconstruction: a protocol for a randomised controlled trial
Isokinetic muscle strength training combined with proprioceptive neuromuscular facilitation for rehabilitation of patients after anterior cruciate ligament reconstruction: a protocol for a randomised controlled trial
IntroductionThe anterior cruciate ligament (ACL) plays a key role in maintaining the static and dynamic stability of the k...
Effect of statins on neurological functional outcomes in critically ill adult patients with traumatic brain injury: a systematic review and meta-analysis
Effect of statins on neurological functional outcomes in critically ill adult patients with traumatic brain injury: a systematic review and meta-analysis
STRENGTHS AND LIMITATIONS OF THIS STUDYOur systematic review was designed to look at recommended patient-centred clinical ...
Perspectives of HPV vaccination among young adults: a qualitative systematic review and evidence synthesis protocol
Perspectives of HPV vaccination among young adults: a qualitative systematic review and evidence synthesis protocol
BackgroundHuman papillomavirus (HPV) is estimated to cause 4.5% of all cancers worldwide and is the causative agent of nea...
Impact of smoking cessation on non-alcoholic fatty liver disease prevalence: a systematic review and meta-analysis
Impact of smoking cessation on non-alcoholic fatty liver disease prevalence: a systematic review and meta-analysis
IntroductionNon-alcoholic fatty liver disease (NAFLD) is regarded as the hepatic manifestation of metabolic syndrome and i...
Young carers perspectives on navigating the healthcare system and co-designing support for their caring roles: a mixed-methods qualitative study
Young carers perspectives on navigating the healthcare system and co-designing support for their caring roles: a mixed-methods qualitative study
Strengths and limitations of this studyThis study was strengthened using multiple research methods (ie, interviews, focus ...
Measuring the success of programmes of care for people living with dementia: a protocol for consensus building with consumers to develop a set of Core Outcome Measures for Improving Care (COM-IC)
Measuring the success of programmes of care for people living with dementia: a protocol for consensus building with consumers to develop a set of Core Outcome Measures for Improving Care (COM-IC)
Background and rationaleDementia is a syndrome characterised by cognitive and functional decline, posing unique and comple...
Multimodality local consolidative treatment versus conventional care of advanced lung cancer after first-line systemic anti-cancer treatment: study protocol for the RAMON multicentre randomised controlled trial with an internal pilot
Multimodality local consolidative treatment versus conventional care of advanced lung cancer after first-line systemic anti-cancer treatment: study protocol for the RAMON multicentre randomised controlled trial with an internal pilot
IntroductionLung cancer is the most common cause of cancer death worldwide and the majority (57%) of patients in the UK pr...
Effectiveness of social support programmes on loneliness in community-dwelling older adults: study protocol for a meta-analysis of randomised controlled trials
Effectiveness of social support programmes on loneliness in community-dwelling older adults: study protocol for a meta-analysis of randomised controlled trials
IntroductionLoneliness is a distressing psychological experience caused by a personal perception of discrepancies between ...
Policy responses to the COVID-19 pandemic in West Africa: a scoping review protocol
Policy responses to the COVID-19 pandemic in West Africa: a scoping review protocol
IntroductionFour years after the devastating Ebola outbreak in West Africa, governments were quick to implement non-pharma...
Influence of physical fitness components on personality factors and risk perception of children and adolescents: a cross-sectional study
Influence of physical fitness components on personality factors and risk perception of children and adolescents: a cross-sectional study
STRENGTHS AND LIMITATIONS OF THIS STUDYThe main strength of the present investigation was the possibility of carrying out ...
Test negative case-control study of COVID-19 vaccine effectiveness for symptomatic SARS-CoV-2 infection among healthcare workers: Zambia, 2021-2022
Test negative case-control study of COVID-19 vaccine effectiveness for symptomatic SARS-CoV-2 infection among healthcare workers: Zambia, 2021-2022
Strengths and limitations of this studyThe study design used in this study has been well described in influenza vaccine ev...
Barriers and opportunities for improving smoke-free area implementation in Banda Aceh city, Indonesia: a qualitative study
Barriers and opportunities for improving smoke-free area implementation in Banda Aceh city, Indonesia: a qualitative study
STRENGTHS AND LIMITATIONS OF THIS STUDYRepresentativeness of sample size and inclusion criteria used in this study enhance...
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