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Hypoxia Modulates Membrane Mechanics in Pancreatic Cancer
Hypoxia Modulates Membrane Mechanics in Pancreatic Cancer
Aggressive cancer cells such as pancreatic cells exhibit an enhanced metastatic phenotype that involves cell migration and...
Design of a Multi-Epitope Vaccine using β-barrel Outer Membrane Proteins Identified in
Design of a Multi-Epitope Vaccine using β-barrel Outer Membrane Proteins Identified in
Chlamydia trachomatis is an obligate intracellular Gram-negative pathogen that causes sexually transmitted infections (STI...
Yeast Membrane Hydration is Maintained Under Ethanol Exposure
Yeast Membrane Hydration is Maintained Under Ethanol Exposure
Yeasts are able to tolerate different environmental conditions, including stress situations. Given their broad application...
Bilayer-Dependent Recognition of Docosahexaenoic Acid by the Transmembrane Domain of FATP3
Bilayer-Dependent Recognition of Docosahexaenoic Acid by the Transmembrane Domain of FATP3
Fatty acid Transport Protein 3 (FATP3) is a single-pass transmembrane protein implicated in the uptake and intracellular t...
Celebrating 50 Years of Single-Channel Recording with the Patch Clamp
Celebrating 50 Years of Single-Channel Recording with the Patch Clamp
Fifty years ago, Erwin Neher and Bert Sakmann published a Nature paper on their recording of discrete, step-like currents ...
Predicting Toxicity of Insect Venom-Derived Antimicrobial Peptides Using MD Simulations: A Comparative Study of Multi-Component and Realistic Mammalian Membrane Models
Predicting Toxicity of Insect Venom-Derived Antimicrobial Peptides Using MD Simulations: A Comparative Study of Multi-Component and Realistic Mammalian Membrane Models
Insect venom-derived antimicrobial peptides (AMPs) hold significant therapeutic promise, but their application is constrai...
Integrative Multiscale Simulations Uncover the Mechanistic Principles Governing COPII Mediated Vesicle Formation
Integrative Multiscale Simulations Uncover the Mechanistic Principles Governing COPII Mediated Vesicle Formation
Arkhipov A, Yin Y, Schulten K (2008) Four-scale description of membrane sculpting by BAR domains. Biophys J 95:2806–2821Ar...
Peptide-Assisted Membrane Permeabilization: Effects of Waveform Polarity, Inter-Monopulse Interval, and Surface Charge in Red Blood Cells and Planar Lipid Bilayers
Peptide-Assisted Membrane Permeabilization: Effects of Waveform Polarity, Inter-Monopulse Interval, and Surface Charge in Red Blood Cells and Planar Lipid Bilayers
Permeabilization of biomembranes by polycationic peptides is known to depend on the membrane potential, although the exact...
Na Uptake Triggered in Adrenal Chromaffin Cells by a 5-ns Electric Pulse is Facilitated by Ca Influx Via an L-Type-Like Ca Channel Independent of Changes in Membrane Potential
Na Uptake Triggered in Adrenal Chromaffin Cells by a 5-ns Electric Pulse is Facilitated by Ca Influx Via an L-Type-Like Ca Channel Independent of Changes in Membrane Potential
Whole-cell voltage patch clamp studies have shown that in bovine adrenal chromaffin cells held at -70 mV, a single 5-ns, 5...
Targeting ORAI1-Mediated Calcium Influx in Triple-Negative Breast Cancer: A Computational Drug Discovery Approach
Targeting ORAI1-Mediated Calcium Influx in Triple-Negative Breast Cancer: A Computational Drug Discovery Approach
Store-operated calcium entry (SOCE) is a crucial pathway that aids in restoring depleted calcium levels in the endoplasmic...
Membrane Remodeling Activity of Dengue Virus NS4A and NS1 Proteins: A Computational Perspective
Membrane Remodeling Activity of Dengue Virus NS4A and NS1 Proteins: A Computational Perspective
Dengue virus (DENV) non-structural protein NS4A and NS1 are crucial for viral replication and have the ability to cause ex...
Analysis of the Effect of the Magnetic Field on Water Flux Through TIP3;1 Aquaporins Using Molecular Dynamics in GROMACS
Analysis of the Effect of the Magnetic Field on Water Flux Through TIP3;1 Aquaporins Using Molecular Dynamics in GROMACS
Magnetobiology studies the effects of magnetic fields on biological systems. In this context, the Magnetobiology Research ...
Oxysterol Induced Fluid-Fluid Phase Separation in Saturated Phosphatidylcholine Membranes: Influence of Lipid Chain Length
Oxysterol Induced Fluid-Fluid Phase Separation in Saturated Phosphatidylcholine Membranes: Influence of Lipid Chain Length
We have recently reported the observation of closed-loop fluid-fluid immiscibility in 1,2-dimyristoyl-sn-glycero-3-phospho...
Rapid Single-cell Measurement of Transient Transmembrane Water Flow under Osmotic Gradient
Rapid Single-cell Measurement of Transient Transmembrane Water Flow under Osmotic Gradient
Aquaporins (AQPs) are critical for transmembrane water transport in response to osmotic gradients, but their gating and re...
Mechanistic Insights into Human Defensin Antimicrobial Activity from Membrane Simulations
Mechanistic Insights into Human Defensin Antimicrobial Activity from Membrane Simulations
Defensins function as critical effectors of innate immunity, displaying broad-spectrum antimicrobial activity against bact...
Deciphering the Influence of Side Chains of Short Cationic Hydrophobic Peptides on Macroscopic and Molecular Properties of Mixed Lipid Bilayers
Deciphering the Influence of Side Chains of Short Cationic Hydrophobic Peptides on Macroscopic and Molecular Properties of Mixed Lipid Bilayers
Cell-penetrating peptides (CPPs) are increasingly used for delivering cargo into cells, but the mechanisms of their membra...
Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein
Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein
Neurological diseases refer to pathological changes that occur in the brain, spinal cord, and peripheral nerves. Their eti...
Single-Molecule Insights into GPCR Conformational Landscapes
Single-Molecule Insights into GPCR Conformational Landscapes
Agyemang E, Gonneville AN, Tiruvadi-Krishnan S, Lamichhane R (2024) Exploring GPCR conformational dynamics using single-mo...
Metabolic Energy is Stored in a Homeostatic Trans-Membrane Water Barochemical Gradient
Metabolic Energy is Stored in a Homeostatic Trans-Membrane Water Barochemical Gradient
Trans-membrane water transport and co-transport is ubiquitous in cell biology. Integrated over all the c...
Correction: Single‑Molecule Insights into GPCR Conformational Landscapes
Correction: Single‑Molecule Insights into GPCR Conformational Landscapes
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
Action of the Terminal Complement Pathway on Cell Membranes
Action of the Terminal Complement Pathway on Cell Membranes
The complement pathway is one of the most ancient elements of the host's innate response and includes a set of protein...
Cholesterol Concentration in Cell Membranes and its Impact on Receptor–Ligand Interaction: A Computational Study of ATP-Sensitive Potassium Channels and ATP Binding
Cholesterol Concentration in Cell Membranes and its Impact on Receptor–Ligand Interaction: A Computational Study of ATP-Sensitive Potassium Channels and ATP Binding
This work describes a computer study that looks at how different amounts of cholesterol (0%, 25%, and 50%) in cell membran...
Pore Formation by Pore Forming Proteins in Lipid Membranes: Structural Insights Through Cryo-EM
Pore Formation by Pore Forming Proteins in Lipid Membranes: Structural Insights Through Cryo-EM
Many pathogenic bacteria utilize their complicated appalling arsenal, bacterial virulence factors, to attack host cells by...
The Effect of Xenon on the Voltage‒Current Characteristics of Tethered Lipid Bilayers
The Effect of Xenon on the Voltage‒Current Characteristics of Tethered Lipid Bilayers
In this study, we describe the effect of the noble gas, xenon on the electrical properties of tethered lipid bilayer membr...
Role of Ion Channels in Alzheimer’s Disease Pathophysiology
Role of Ion Channels in Alzheimer’s Disease Pathophysiology
Ion channels play an integral role in the normal functioning of the brain. They regulate neuronal electrical properties li...
Cholesterol Affects the Pore Formation and the Membrane–Membrane Interaction Induced by an Antimicrobial Peptide, NK-2, in Phospholipid Vesicles
Cholesterol Affects the Pore Formation and the Membrane–Membrane Interaction Induced by an Antimicrobial Peptide, NK-2, in Phospholipid Vesicles
Antimicrobial peptides are part of the innate immune response and show their antimicrobial activity by forming pores, foll...
Functional and Physiological Implications of Oligopeptide Transporters: Potential Targets for Pharmacological Interventions
Functional and Physiological Implications of Oligopeptide Transporters: Potential Targets for Pharmacological Interventions
Peptide transporters are important plasma membrane proteins that facilitate the cellular uptake of di- and tripeptides in ...
Oxysterols Outcompete Cholesterol Binding to the Membrane-Inserted Cytolysin A Pore Complex
Oxysterols Outcompete Cholesterol Binding to the Membrane-Inserted Cytolysin A Pore Complex
Pore-forming toxins (PFTs) belong to a class of proteins expressed by bacteria to initiate infections by unregulated pore ...
Resurrection of the Helical Hairpin Hypothesis for Understanding Coronavirus Fusion
Resurrection of the Helical Hairpin Hypothesis for Understanding Coronavirus Fusion
Coronaviruses use the spike protein (spike) to bind to target cells, and fuse the viral envelope with a host lipi...
Biomimetic Bacterial Membrane Models for Comprehending Membrane Dynamics
Biomimetic Bacterial Membrane Models for Comprehending Membrane Dynamics
Boucher HW et al (2009) Bad bugs, no drugs: no ESKAPE! An update from the infectious diseases society of America. Clin Inf...
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