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Efficacy and safety of SGLT2 inhibitors in nondiabetic patients with CKD: a review of recent evidence
Efficacy and safety of SGLT2 inhibitors in nondiabetic patients with CKD: a review of recent evidence
Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) were initially developed as glucose-lowering agents in pati...
Strategies to improve long-term outcomes for patients with chronic kidney disease in China
Strategies to improve long-term outcomes for patients with chronic kidney disease in China
Background: Chronic kidney disease (CKD) is an incurable disease requiring lifelong management. China has a high prevalenc...
Kidney Involvement in Autoinflammatory Diseases
Kidney Involvement in Autoinflammatory Diseases
<b><i>Background:</i></b> Autoinflammatory diseases (AIDs) were first proposed 20 years ago and ca...
From physiology to pathology: the role of mitochondria in acute kidney injuries and chronic kidney diseases
From physiology to pathology: the role of mitochondria in acute kidney injuries and chronic kidney diseases
Background: Renal diseases remain an increasing public health issue affecting millions of people. The kidney is a highly e...
Therapeutic potential targeting podocyte mitochondrial dysfunction in focal segmental glomerulosclerosis
Therapeutic potential targeting podocyte mitochondrial dysfunction in focal segmental glomerulosclerosis
Background：Podocytes are essential components of the glomerular filtration barrier and essential for the proper filtration...
Develop and Validate a Risk Score in Predicting Renal Failure in Focal Segmental Glomerulosclerosis
Develop and Validate a Risk Score in Predicting Renal Failure in Focal Segmental Glomerulosclerosis
Introduction The aim of this study is to develop and validate a risk score for end stage kidney disease (ESKD) in patients...
Role of IL-6 family cytokines in organ fibrosis
Role of IL-6 family cytokines in organ fibrosis
Background: Organ fibrosis remains an important cause of high incidence rate and mortality worldwide. The prominent role o...
Hospitalizations of chronic dialysis patients: a national study in China
Hospitalizations of chronic dialysis patients: a national study in China
Background Patients receiving chronic dialysis are usually with multiple comorbidities and at high-risk for hospitalizatio...
Nephropathy is aggravated by fatty acids in diabetic kidney disease through tubular epithelial cell necroptosis and is alleviated by an RIPK-1 inhibitor
Nephropathy is aggravated by fatty acids in diabetic kidney disease through tubular epithelial cell necroptosis and is alleviated by an RIPK-1 inhibitor
Introduction: Diabetic kidney disease (DKD), one of the leading causes of end-stage renal disease, has complex pathogenic ...
A panoramic view of ferroptosis in cardiovascular disease
A panoramic view of ferroptosis in cardiovascular disease
Background: Cardiovascular disease (CVD) remains the leading cause of disease burden worldwide. Ferroptosis, an iron-depen...
Impact of Angiopoietin-2 on Kidney Diseases
Impact of Angiopoietin-2 on Kidney Diseases
<b><i>Background:</i></b> Angiopoietins (Ang) are essential angiogenic factors involved in angioge...
Clinical Outcomes in Patients on Hemodialysis with Congestive Heart Failure
Clinical Outcomes in Patients on Hemodialysis with Congestive Heart Failure
Introduction: Congestive heart failure (CHF) is one of the common complications in patients with end-stage kidney disease....
Renal involvement in autoinflammatory diseases
Renal involvement in autoinflammatory diseases
Background: Autoinflammatory diseases (AIDs) were first proposed 20 years ago and caused by dysregulation of the innate im...
Exosomes in Diabetic Kidney Disease
Exosomes in Diabetic Kidney Disease
Background: Diabetic kidney disease (DKD) is a major complication of diabetes mellitus and a common cause of end-stage kid...
Efficacy and safety of belimumab in lupus nephritis patients: a real-world observational study in China
Efficacy and safety of belimumab in lupus nephritis patients: a real-world observational study in China
BACKGROUND: This study aimed to describe disease activity, clinical outcome and overall patterns of lupus nephritis care i...
Defining biventricular abnormalities by cardiac magnetic resonance in pre-dialysis patients with chronic kidney disease
Defining biventricular abnormalities by cardiac magnetic resonance in pre-dialysis patients with chronic kidney disease
Introduction: To investigate biventricular structural and functional abnormalities in pre-dialysis patients across stages ...
Evaluation of Therapies for Secondary Hyperparathyroidism Associated with Vitamin D Insufficiency in Chronic Kidney Disease
Evaluation of Therapies for Secondary Hyperparathyroidism Associated with Vitamin D Insufficiency in Chronic Kidney Disease
Abstract Introduction: Parathyroid hormone-lowering responses after administration of three different therapies capable o...
IL-37 Ameliorates Renal Fibrosis by Restoring CPT1A Mediated Fatty Acid Oxidation in Diabetic Kidney Disease
IL-37 Ameliorates Renal Fibrosis by Restoring CPT1A Mediated Fatty Acid Oxidation in Diabetic Kidney Disease
Introduction: Diabetic kidney disease (DKD) is a major source of chronic kidney disease (CKD) and end-stage renal disease ...
Clinical characteristics and management of patients with secondary hyperparathyroidism undergoing hemodialysis: a feasibility analysis of electronic health records using Natural Language Processing
Clinical characteristics and management of patients with secondary hyperparathyroidism undergoing hemodialysis: a feasibility analysis of electronic health records using Natural Language Processing
Introduction: This study aimed to assess the feasibility of applying Natural Language Processing (NLP) to analyze real-wor...
Impact of Weight Gain on the Subsequent Survival of New Peritoneal Dialysis Patients
Impact of Weight Gain on the Subsequent Survival of New Peritoneal Dialysis Patients
Introduction: Obesity at the initiation of dialysis was reported to adversely affect the clinical outcome of peritoneal di...
Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease
Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease
<b><i>Introduction:</i></b> The number of patients with chronic kidney disease (CKD) is increasing...
Nonsteroidal Mineralocorticoid Receptor Antagonist Eliciting Cardiorenal Protection Is a New Option for Patients with Chronic Kidney Disease
Nonsteroidal Mineralocorticoid Receptor Antagonist Eliciting Cardiorenal Protection Is a New Option for Patients with Chronic Kidney Disease
<b><i>Background:</i></b> Mineralocorticoid receptor antagonists (MRAs) protect cardiorenal functi...
Efficacy and Safety of Sevelamer Carbonate in Chinese Nondialysis Chronic Kidney Disease Patients with Hyperphosphatemia: A Randomized, Double-Blind, Parallel-Group Study
Efficacy and Safety of Sevelamer Carbonate in Chinese Nondialysis Chronic Kidney Disease Patients with Hyperphosphatemia: A Randomized, Double-Blind, Parallel-Group Study
Introduction: Previous studies suggested that sevelamer carbonate is well tolerated with a favorable efficacy and safety p...
Role of C-Reactive Protein in Kidney Diseases
Role of C-Reactive Protein in Kidney Diseases
Background: C-reactive protein (CRP) is an acute phase protein and has been found to be a risk factor for acute renal inj...
Loss of Pten in renal tubular cells leads to water retention by upregulating AQP2
Loss of Pten in renal tubular cells leads to water retention by upregulating AQP2
Introduction: Phosphatase and tensin (PTEN) is a multifunctional gene associated with the normal development and physiolog...
Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 Patients
Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 Patients
<b><i>Introduction:</i></b> Complex integrated information on disease mechanisms and in-hospital o...
Musculoskeletal ultrasound evaluates renal injury and predicts renal outcome in patients with gout
Musculoskeletal ultrasound evaluates renal injury and predicts renal outcome in patients with gout
Introduction. Kidney injury diagnosis is often delayed in patients with gout. We aimed to determine the characteristics of...
Eosinophils: A Friend or Foe in human health and diseases
Eosinophils: A Friend or Foe in human health and diseases
Since their discovery, around 150 years, eosinophils research has been a field of changing perspective, and new directions...
The Mechanism of Delayed Ischemic Preconditioning in Alleviating Acute Ischemia/Reperfusion Renal Injury through Treg Mediated by Immature CD11c+ Dendritic Cells
The Mechanism of Delayed Ischemic Preconditioning in Alleviating Acute Ischemia/Reperfusion Renal Injury through Treg Mediated by Immature CD11c+ Dendritic Cells
<b><i>Introduction:</i></b> Renal ischemia-reperfusion injury (IRI) is one of the major causes of ...
Non-steroidal Mineralocorticoid Receptor Antagonist Eliciting Cardiorenal Protection is a New Option for Patients with Chronic Kidney Disease
Non-steroidal Mineralocorticoid Receptor Antagonist Eliciting Cardiorenal Protection is a New Option for Patients with Chronic Kidney Disease
Background: Mineralocorticoid receptor antagonists (MRAs) protect cardiorenal function by robust anti-inflammatory and an...
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