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Knee immobilization reproduces key arthrofibrotic phenotypes in mice
Knee immobilization reproduces key arthrofibrotic phenotypes in mice
AimsAs has been shown in larger animal models, knee immobilization can lead to arthrofibrotic phenotypes. Our study includ...
Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage
Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage
AimsAfter a few passages of in vitro culture, primary human articular chondrocytes undergo senescence and loss of their ph...
A radio- and fluorescently labelled tracer for imaging and quantification of bacterial infection on orthopaedic prostheses
A radio- and fluorescently labelled tracer for imaging and quantification of bacterial infection on orthopaedic prostheses
AimsArthroplasty surgery of the knee and hip is performed in two to three million patients annually. Periprosthetic joint ...
CircStrn3 targeting microRNA-9-5p is involved in the regulation of cartilage degeneration and subchondral bone remodelling in osteoarthritis
CircStrn3 targeting microRNA-9-5p is involved in the regulation of cartilage degeneration and subchondral bone remodelling in osteoarthritis
AimsCircular RNA (circRNA) is involved in the regulation of articular cartilage degeneration induced by inflammatory facto...
Femoral impingement in maximal hip flexion is anterior-inferior distal to the cam deformity in femoroacetabular impingement patients with femoral retroversion
Femoral impingement in maximal hip flexion is anterior-inferior distal to the cam deformity in femoroacetabular impingement patients with femoral retroversion
AimsFemoroacetabular impingement (FAI) patients report exacerbation of hip pain in deep flexion. However, the exact imping...
Anterior cruciate ligament remnant preservation attenuates apoptosis and enhances the regeneration of hamstring tendon graft
Anterior cruciate ligament remnant preservation attenuates apoptosis and enhances the regeneration of hamstring tendon graft
AimsThe effects of remnant preservation on the anterior cruciate ligament (ACL) and its relationship with the tendon graft...
Predicted waiting times for orthopaedic surgery
Predicted waiting times for orthopaedic surgery
Cite this article: Bone Joint Res 2022;11(12):890–892.
Molecular crosstalk between articular cartilage, meniscus, synovium, and subchondral bone in osteoarthritis
Molecular crosstalk between articular cartilage, meniscus, synovium, and subchondral bone in osteoarthritis
AimsOsteoarthritis (OA) is a common degenerative joint disease worldwide, which is characterized by articular cartilage le...
The prevalence and treatment of osteoporosis in patients undergoing total hip arthroplasty and the levels of biochemical markers of bone turnover
The prevalence and treatment of osteoporosis in patients undergoing total hip arthroplasty and the levels of biochemical markers of bone turnover
AimsOsteoporosis is common in total hip arthroplasty (THA) patients. It plays a substantial factor in the surgery’s outcom...
Volume and location of bone regeneration after autologous expanded mesenchymal stromal cells in hip osteonecrosis
Volume and location of bone regeneration after autologous expanded mesenchymal stromal cells in hip osteonecrosis
AimsSuccessful cell therapy in hip osteonecrosis (ON) may help to avoid ON progression or total hip arthroplasty (THA), bu...
Developmental endothelial locus-1 attenuates palmitate-induced apoptosis in tenocytes through the AMPK/autophagy-mediated suppression of inflammation and endoplasmic reticulum stress
Developmental endothelial locus-1 attenuates palmitate-induced apoptosis in tenocytes through the AMPK/autophagy-mediated suppression of inflammation and endoplasmic reticulum stress
AimsMyokine developmental endothelial locus-1 (DEL-1) has been documented to alleviate inflammation and endoplasmic reticu...
The role of Staphylococcus aureus small colony variants in intraosseous invasion and colonization in periprosthetic joint infection
The role of Staphylococcus aureus small colony variants in intraosseous invasion and colonization in periprosthetic joint infection
AimsThis study aimed to explore the role of small colony variants (SCVs) of Staphylococcus aureus in intraosseous invasion...
Cyclin D1 mediates pain behaviour in a rat model of breast cancer-induced bone pain by a mechanism involving regulation of the proliferation of spinal microglia
Cyclin D1 mediates pain behaviour in a rat model of breast cancer-induced bone pain by a mechanism involving regulation of the proliferation of spinal microglia
AimsThe involvement of cyclin D1 in the proliferation of microglia, and the generation and maintenance of bone cancer pain...
The incidence of musculoskeletal injuries: a systematic review and meta-analysis
The incidence of musculoskeletal injuries: a systematic review and meta-analysis
AimsThe aim of this systematic review and meta-analysis was to gather epidemiological information on selected musculoskele...
Bisphosphonate use is associated with a decreased joint narrowing rate in the non-arthritic hip
Bisphosphonate use is associated with a decreased joint narrowing rate in the non-arthritic hip
AimsThe preventive effects of bisphosphonates on articular cartilage in non-arthritic joints are unclear. This study aimed...
Wound fluid ceftriaxone concentrations after local application with calcium sulphate as carrier material in the treatment of orthopaedic device-associated hip infections
Wound fluid ceftriaxone concentrations after local application with calcium sulphate as carrier material in the treatment of orthopaedic device-associated hip infections
AimsThere is a considerable challenge in treating bone infections and orthopaedic device-associated infection (ODAI), part...
Comparison of ligamentization potential between anterior cruciate ligament-derived cells and adipose-derived mesenchymal stem cells reseeded to acellularized tendon allograft
Comparison of ligamentization potential between anterior cruciate ligament-derived cells and adipose-derived mesenchymal stem cells reseeded to acellularized tendon allograft
AimsTo test the hypothesis that reseeded anterior cruciate ligament (ACL)-derived cells have a better ability to survive a...
Extended local release and improved bacterial eradication by adding rifampicin to a biphasic ceramic carrier containing gentamicin or vancomycin
Extended local release and improved bacterial eradication by adding rifampicin to a biphasic ceramic carrier containing gentamicin or vancomycin
AimsThere is a lack of biomaterial-based carriers for the local delivery of rifampicin (RIF), one of the cornerstone secon...
Complete abrogation of key osteoclast markers with a membrane-anchored tissue inhibitor of metalloproteinase
Complete abrogation of key osteoclast markers with a membrane-anchored tissue inhibitor of metalloproteinase
AimsTissue inhibitors of metalloproteinases (TIMPs) are the endogenous inhibitors of the zinc-dependent matrix metalloprot...
Systemic administration with melatonin in the daytime has a better effect on promoting osseointegration of titanium rods in ovariectomized rats
Systemic administration with melatonin in the daytime has a better effect on promoting osseointegration of titanium rods in ovariectomized rats
AimsThis study examined whether systemic administration of melatonin would have different effects on osseointegration in o...
Importance of posterior tibial slope in joint kinematics with an anterior cruciate ligament-deficient knee
Importance of posterior tibial slope in joint kinematics with an anterior cruciate ligament-deficient knee
AimsTo fully quantify the effect of posterior tibial slope (PTS) angles on joint kinematics and contact mechanics of intac...
Suramin enhances chondrogenic properties by regulating the p67phox/PI3K/AKT/SOX9 signalling pathway
Suramin enhances chondrogenic properties by regulating the p67phox/PI3K/AKT/SOX9 signalling pathway
AimsAutologous chondrocyte implantation (ACI) is a promising treatment for articular cartilage degeneration and injury; ho...
Current therapeutic interventions combating biofilm-related infections in orthopaedics
Current therapeutic interventions combating biofilm-related infections in orthopaedics
AimsBiofilm-related infection is a major complication that occurs in orthopaedic surgery. Various treatments are available...
Radiodynamic therapy with acridine orange local administration as a new treatment option for primary and secondary bone tumours
Radiodynamic therapy with acridine orange local administration as a new treatment option for primary and secondary bone tumours
AimsAcridine orange (AO) demonstrates several biological activities. When exposed to low doses of X-ray radiation, AO incr...
Mortality and re-revision following single-stage and two-stage revision surgery for the management of infected primary knee arthroplasty in England and Wales
Mortality and re-revision following single-stage and two-stage revision surgery for the management of infected primary knee arthroplasty in England and Wales
AimsWe compared the risks of re-revision and mortality between two-stage revision surgery and single-stage revision surger...
ATF3 as a potential diagnostic marker of early-stage osteoarthritis and its correlation with immune infiltration through bioinformatics analysis
ATF3 as a potential diagnostic marker of early-stage osteoarthritis and its correlation with immune infiltration through bioinformatics analysis
AimsThis study aimed, through bioinformatics analysis, to identify the potential diagnostic markers of osteoarthritis, and...
Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability
Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability
AimsExosomes (exo) are involved in the progression of osteoarthritis (OA). This study aimed to investigate the function of...
Septic arthritis in an in vivo murine model induced by Staphylococcus aureus
Septic arthritis in an in vivo murine model induced by Staphylococcus aureus
AimsStaphylococcus aureus is a major cause of septic arthritis, and in vitro studies suggest α haemolysin (Hla) is respons...
Mucin 1 aggravates synovitis and joint damage of rheumatoid arthritis by regulating inflammation and aggression of fibroblast-like synoviocytes
Mucin 1 aggravates synovitis and joint damage of rheumatoid arthritis by regulating inflammation and aggression of fibroblast-like synoviocytes
AimsTo explore the synovial expression of mucin 1 (MUC1) and its role in rheumatoid arthritis (RA), as well as the possibl...
Diagnosing periprosthetic joint infections
Diagnosing periprosthetic joint infections
AimsThis study evaluated the definitions developed by the European Bone and Joint Infection Society (EBJIS) 2021, the Inte...
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