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Sialin-STAT3 axis regulates bone homeostasis in mice
Sialin-STAT3 axis regulates bone homeostasis in mice
Mitochondrial regulation in mesenchymal stem cells (MSCs) serves as a critical determinant of bone formation and skeletal ...
Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network
Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network
Endochondral ossification is a physiological process involving a sequential formation of cartilage and bone tissues. Class...
Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone
Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone
Obesity and type-2 diabetes, two interconnected and increasingly prevalent metabolic disorders, are associated with poor b...
Estradiol regulates osteoclast sialylation via ST3Gal1 in postmenopausal osteoporosis
Estradiol regulates osteoclast sialylation via ST3Gal1 in postmenopausal osteoporosis
Estrogen deficiency after menopause accelerates bone loss by stimulating osteoclast formation and activity, but the molecu...
Advances in the mechanism for steroid-induced osteonecrosis of the femoral head
Advances in the mechanism for steroid-induced osteonecrosis of the femoral head
Steroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating condition resulting from the use of glucocorti...
Smart biomaterials for skeletal aging repair and regeneration
Smart biomaterials for skeletal aging repair and regeneration
Skeletal aging associated with diverse age-related disorders is increasing due to unhealthy diets, stressful lifestyles, a...
HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm
HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm
Bone regeneration is initiated after a bone injury, such as a bone fracture or tooth extraction. It is a highly complex bi...
Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis
Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis
Osteoarthritis (OA) is an aging-related degenerative joint disease without effective therapies. In the early stage of OA, ...
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis
Itaconate, a macrophage-specific anti-inflammatory metabolite, has recently emerged as a critical regulator in rheumatoid ...
Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis
Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease in which synovial fibroblasts (SFs) maintain chronic inflammati...
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
Intervertebral disc degeneration (IDD) is a progressive and dynamic process in which the senescence-associated secretory p...
Different role of the gut microbiota in postmenopausal and senile osteoporosis
Different role of the gut microbiota in postmenopausal and senile osteoporosis
Fan, Y. & Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 55–71 (2021).Art...
Pathophysiology of Myopenia in rheumatoid arthritis
Pathophysiology of Myopenia in rheumatoid arthritis
Rheumatoid arthritis (RA) is a prevalent and debilitating inflammatory disease that significantly impairs functional capac...
Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice
Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice
Membrane-initiated estrogen receptor α (mERα) signaling has been shown to affect bone mass in murine models. How...
ER-induced PERK/TFEB cascade sequentially modulates mitochondrial dynamics during cranial suture expansion
ER-induced PERK/TFEB cascade sequentially modulates mitochondrial dynamics during cranial suture expansion
The effectiveness of cranial suture expansion therapy hinges on the timely and adequate regeneration of bone tissue in res...
Reduced somatosensory innervation alters the skeletal transcriptome at a single cell level in a mouse model of type 2 diabetes
Reduced somatosensory innervation alters the skeletal transcriptome at a single cell level in a mouse model of type 2 diabetes
Peripheral neuropathy is a common complication in diabetes, affecting around 50% of the diabetic population. Co-occurrence...
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral nerve end...
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent tr...
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge, as ...
A new perspective on intervertebral disc calcification—from bench to bedside
A new perspective on intervertebral disc calcification—from bench to bedside
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to unders...
The role and applications of extracellular vesicles in osteoporosis
The role and applications of extracellular vesicles in osteoporosis
Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture...
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized ...
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Skeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone regenerative potential with aging, but ...
Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications
Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications
Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues, including cartilage, bone, sy...
Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amou...
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
Bone formation is a highly energy-demanding process that can be impacted by metabolic disorders. Glucose has been consider...
Structure and function of the membrane microdomains in osteoclasts
Structure and function of the membrane microdomains in osteoclasts
The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed ...
Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways
Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways
Hand osteoarthritis is a common heterogeneous joint disorder with unclear molecular mechanisms and no disease-modifying dr...
Spatial transcriptomic interrogation of the murine bone marrow signaling landscape
Spatial transcriptomic interrogation of the murine bone marrow signaling landscape
Self-renewal and differentiation of skeletal stem and progenitor cells (SSPCs) are tightly regulated processes, with SSPC ...
Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization
Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization
Matrix vesicles (MVs) have shown strong effects in diseases such as vascular ectopic calcification and pathological calcif...
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