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Timing of MOG-IgG Testing Is Key to 2023 MOGAD Diagnostic Criteria
Timing of MOG-IgG Testing Is Key to 2023 MOGAD Diagnostic Criteria
AbstractBackground and Objectives Myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD) is a recen...
Antibody Investigations in 2,750 Children With Suspected Autoimmune Encephalitis
Antibody Investigations in 2,750 Children With Suspected Autoimmune Encephalitis
AbstractObjectives To assess the frequency and types of neuronal and glial (neural) antibodies in children with suspected ...
Early Neuroaxonal Damage in Neurologic Disorders Associated With GAD65 Antibodies
Early Neuroaxonal Damage in Neurologic Disorders Associated With GAD65 Antibodies
AbstractObjectives Neurodegeneration is considered a relevant pathophysiologic feature in neurologic disorders associated ...
Increased Intracranial Pressure in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
Increased Intracranial Pressure in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
ResultsCohort With OP Measured on LPAmong 86 children diagnosed with MOGAD, 82 (95.3%) had an LP and 43 (50.0%) had an OP ...
Mitoxantrone in NMO Spectrum Disorder in a Large Multicenter Cohort in French Caribbean
Mitoxantrone in NMO Spectrum Disorder in a Large Multicenter Cohort in French Caribbean
IntroductionNeuromyelitis optica spectrum disorder (NMOSD) includes relapsing inflammatory demyelinating disorders affecti...
Clinical Determinants of Longitudinal Disability in LGI-1-IgG Autoimmune Encephalitis
Clinical Determinants of Longitudinal Disability in LGI-1-IgG Autoimmune Encephalitis
AbstractBackground and Objectives Longitudinal outcome studies in leucine-rich glioma inactivated-1 (LGI-1) immunoglobulin...
Neuropsychological Testing in Autoimmune Encephalitis: A Scoping Review
Neuropsychological Testing in Autoimmune Encephalitis: A Scoping Review
The most frequent impairments across neural-IgG AE cohorts were found on the measures of visual and verbal learning/memory...
Resident Memory-like CD8+ T Cells Are Involved in Chronic Inflammatory and Neurodegenerative Diseases in the CNS
Resident Memory-like CD8+ T Cells Are Involved in Chronic Inflammatory and Neurodegenerative Diseases in the CNS
AbstractBackground and Objectives Resident memory T (Trm) cells are a unique population that can survive and function in a...
Glial Fibrillary Acidic Protein Autoimmunity After Aseptic Meningitis: A Report of 2 Cases
Glial Fibrillary Acidic Protein Autoimmunity After Aseptic Meningitis: A Report of 2 Cases
Case 1A 55-year-old female patient was referred from an external hospital with meningoencephalomyelitis. The symptoms had ...
Antibody-Negative Autoimmune Encephalitis: A Single-Center Retrospective Analysis
Antibody-Negative Autoimmune Encephalitis: A Single-Center Retrospective Analysis
AbstractBackground and Objectives Autoimmune encephalitis (AE) refers to a heterogenous group of inflammatory CNS diseases...
Immune Checkpoint Inhibition-Related Myasthenia-Myositis-Myocarditis Responsive to Complement Blockade
Immune Checkpoint Inhibition-Related Myasthenia-Myositis-Myocarditis Responsive to Complement Blockade
AbstractObjective Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but come with immune-related adve...
Long-term Effects of IL-6 Receptor Blockade Therapy on Regulatory Lymphocytes and Neutrophils in Neuromyelitis Optica Spectrum Disorder
Long-term Effects of IL-6 Receptor Blockade Therapy on Regulatory Lymphocytes and Neutrophils in Neuromyelitis Optica Spectrum Disorder
AbstractBackground and Objectives Neuromyelitis optica spectrum disorder (NMOSD) is a disabling autoimmune neurologic dise...
Increasing Neurofilament and Glial Fibrillary Acidic Protein After Treatment Discontinuation Predicts Multiple Sclerosis Disease Activity
Increasing Neurofilament and Glial Fibrillary Acidic Protein After Treatment Discontinuation Predicts Multiple Sclerosis Disease Activity
IntroductionPatients with multiple sclerosis (MS) who have been stable for many years may be interested in discontinuing t...
Chronic Enterovirus Meningoencephalitis in Prolonged B-Cell Depletion After Rituximab Therapy: Case Report
Chronic Enterovirus Meningoencephalitis in Prolonged B-Cell Depletion After Rituximab Therapy: Case Report
IntroductionWe present the case of a 38-year-old man with chronic enterovirus meningoencephalitis due to unrecognized, per...
The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography
The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography
AbstractBackground and Objectives Optical coherence tomography angiography (OCTA) is a noninvasive high-resolution imaging...
Multiple Sclerosis, Disease-Modifying Therapies, and Infections
Multiple Sclerosis, Disease-Modifying Therapies, and Infections
AbstractBackground and Objectives The use of highly effective multiple sclerosis (MS) disease-modifying therapies (DMTs) i...
Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey
Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey
IntroductionStiff-person syndrome (SPS) is a rare autoimmune neurologic disorder characterized by progressive axial muscle...
Natalizumab Treatment Induces Proinflammatory CD4 T Cells Preferentially in the Integrin {beta}7+ Compartment
Natalizumab Treatment Induces Proinflammatory CD4 T Cells Preferentially in the Integrin {beta}7+ Compartment
AbstractBackground and Objectives Natalizumab, a monoclonal humanized antibody targeting integrin α4, inhibits the transmi...
mRNA COVID-19 Vaccination Does Not Exacerbate Symptoms or Trigger Neural Antibody Responses in Multiple Sclerosis
mRNA COVID-19 Vaccination Does Not Exacerbate Symptoms or Trigger Neural Antibody Responses in Multiple Sclerosis
AbstractBackground and Objective In people with multiple sclerosis (pwMS), concern for potential disease exacerbation or t...
A 28-Year-Old Woman With Left-Sided Weakness and Atypical MRI Lesions: From the National Multiple Sclerosis Society Case Conference Proceedings
A 28-Year-Old Woman With Left-Sided Weakness and Atypical MRI Lesions: From the National Multiple Sclerosis Society Case Conference Proceedings
AbstractA 28-year-old woman presented with subacute relapsing left-sided weakness. MRI demonstrated both enhancing C3-C6 a...
Kappa Free Light Chain Index Predicts Disease Course in Clinically and Radiologically Isolated Syndromes
Kappa Free Light Chain Index Predicts Disease Course in Clinically and Radiologically Isolated Syndromes
AbstractBackground and Objectives To evaluate whether the kappa free light chain index (K-index) can predict the occurrenc...
Peptides From the Variable Domain of Immunoglobulin G as Biomarkers in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Peptides From the Variable Domain of Immunoglobulin G as Biomarkers in Chronic Inflammatory Demyelinating Polyradiculoneuropathy
IntroductionChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a neuroinflammatory disorder demonstrating...
Immunotherapy-Responsive Neuropathic Pain and Allodynia in a Patient With Glycine Receptor Autoantibodies: A Case Report
Immunotherapy-Responsive Neuropathic Pain and Allodynia in a Patient With Glycine Receptor Autoantibodies: A Case Report
AbstractObjectives Neuropathic pain is common and distressing. Improved mechanistic understanding and pharmacotherapies ar...
SARS-CoV-2-Specific Immune Responses in Patients With Postviral Syndrome After Suspected COVID-19
SARS-CoV-2-Specific Immune Responses in Patients With Postviral Syndrome After Suspected COVID-19
AbstractBackground and Objectives Millions of Americans were exposed to SARS-CoV-2 early in the pandemic but could not get...
Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies
Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies
AbstractBackground and Objectives Autoimmune-associated epilepsy (AAE) with antiglutamic acid decarboxylase 65 (GAD65) ant...
Trigeminal Nerve Involvement in Bulbar-Onset Anti-IgLON5 Disease
Trigeminal Nerve Involvement in Bulbar-Onset Anti-IgLON5 Disease
AbstractObjectives Anti-IgLON5 disease (IgLON5-D) may present with a bulbar-onset motor neuron disease-like phenotype, mim...
Efficacy of Rituximab Outlasts B-Cell Repopulation in Multiple Sclerosis: Time to Rethink Dosing?
Efficacy of Rituximab Outlasts B-Cell Repopulation in Multiple Sclerosis: Time to Rethink Dosing?
AbstractBackground and Objectives Patients with multiple sclerosis (PwMS) receiving extended dosing of rituximab (RTX) hav...
Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head
Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head
IntroductionAntileucine-rich glioma-inactivated-1 (LGI1) autoimmune encephalitis was first described in 20101,2 and is tod...
IgG1-3 MuSK Antibodies Inhibit AChR Cluster Formation, Restored by SHP2 Inhibitor, Despite Normal MuSK, DOK7, or AChR Subunit Phosphorylation
IgG1-3 MuSK Antibodies Inhibit AChR Cluster Formation, Restored by SHP2 Inhibitor, Despite Normal MuSK, DOK7, or AChR Subu...
Dramatic Response to Anti-IL-6 Receptor Therapy in Children With Life-Threatening Myelin Oligodendrocyte Glycoprotein-Associated Disease
AbstractObjectives Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated neuroinfl...
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