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Progress and challenges in sporadic late-onset cerebellar ataxias
Progress and challenges in sporadic late-onset cerebellar ataxias
Sporadic late-onset cerebellar ataxia (SLOCA) is a syndrome defined by subacute or chronic and progressive ataxia occurrin...
Myotonic dystrophy type 1: clinical diversity, molecular insights and therapeutic perspectives
Myotonic dystrophy type 1: clinical diversity, molecular insights and therapeutic perspectives
Myotonic dystrophy type 1 (DM1) is the most prevalent muscular dystrophy in adulthood and is one of the most clinically di...
GLP-1 is implicated in area postrema syndrome in people with NMOSD
A new study presented at the 2025 American Neurological Association Annual Meeting indicates that area postrema syndrome i...
Timing of hormone replacement therapy could influence Alzheimer disease risk
Timing of hormone replacement therapy could influence Alzheimer disease risk
A new meta-analysis presented at the 2025 American Neurological Association Annual Meeting shows that initiation of hormon...
Real-world effectiveness of stem cell transplantation for multiple sclerosis
Autologous haematopoietic stem cell transplantation (AHSCT) offers effective therapy for people with multiple sclerosis (M...
Glioblastomas divert glucose to promote growth
Glioblastomas can shift glucose metabolism from tricarboxylic acid cycle (TCA) oxidation and neurotransmitter synthesis to...
Cerebellar pathology in spinal muscular atrophy
Cerebellar pathology in people with type 1 spinal muscular atrophy (SMA) might contribute to motor and social communicatio...
The impact of rare genetic variants on Alzheimer disease
The impact of rare genetic variants on Alzheimer disease
Alzheimer disease (AD) is a progressive neurodegenerative disease with a strong genetic component. Although autosomal domi...
Nothing about us, without us — establishing a patient and public involvement and engagement group
Nothing about us, without us — establishing a patient and public involvement and engagement group
Implementation of patient and public involvement and engagement (PPIE) to enable patients and carers to feel included and ...
Moving towards meaningful patient and public engagement
Patient and public involvement and engagement is increasingly mandated in funding applications, yet often remain tokenisti...
CNS drug delivery improves chemotherapy
Glioblastoma-associated macrophages (GAMs) have been effectively targeted with chemotherapy drugs that were modified to cr...
Neurogenesis altered by disease and stimulation
Neurogenesis in the subventricular zone (SVZ) is altered in neurodegenerative diseases and activated by deep brain stimula...
Parkinson disease pathology can originate in the kidney
New research suggests that pathological α-synuclein in Parkinson disease can propagate from kidney to brain.
Identification of neurons involved in schizophrenia
Brain cell types associated with schizophrenia have been identified in a new analysis. The researchers combined data from ...
Improved quality of life with MS treatment
Cladribine tablets can improve quality of life in people with highly active relapsing multiple sclerosis (MS), according t...
IGFBP2 levels associated with Alzheimer disease
A study published in Brain has found correlations between serum and cerebrospinal fluid levels of insulin-like growth fact...
A multiple hits hypothesis for memory dysfunction in Parkinson disease
A multiple hits hypothesis for memory dysfunction in Parkinson disease
Cognitive disorders are increasingly recognized in Parkinson disease (PD), even in early disease stages, and memory is one...
Restoring synaptic plasticity after stroke
Gamma oscillations induced by optogenetic stimulation restore functional synaptic plasticity in a mouse model of stroke, a...
CD11c+ macrophages mediate brain-to-gut α-synuclein trafficking
CD11c+ macrophages mediate brain-to-gut α-synuclein trafficking
New research indicates that in a mouse model of Parkinson disease, α-synuclein is trafficked from the brain to the gu...
ALS pathogenesis linked to actin barrier collapse
Repulsive guidance molecule A (RGMa) regulates actin dynamics via neogenin 1 signalling. A new study found that the cerebr...
A tale of race and B cells in multiple sclerosis
A new study indicates that African American people with multiple sclerosis have higher markers of humoral disease patholog...
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
Understanding rare genetic brain disorders with overlapping neurological and psychiatric phenotypes is of increasing impor...
A new biological classification for Parkinson disease
In a plenary lecture at the XXVI World Congress of Neurology, Anthony Lang presented a new biological classification model...
Metformin protects against dementia in diabetes
Use of metformin in people aged ≥60 years with type 2 diabetes mellitus (T2DM) is associated with a reduced risk of develo...
Glioblastoma tackled with oncolytic virus
A first-in-human trial indicates that treatment with an oncolytic virus is associated with increased survival in people wi...
Myelination mediates benefits of ketamine
Restoration of impaired myelination underlies the long-lasting antidepressant effects of ketamine, new research suggests. ...
Peripheral B cells altered in Parkinson disease
The findings of an immunophenotyping study suggest that abnormal peripheral B cell responses could contribute to Parkinson...
Biomarkers in amyotrophic lateral sclerosis: current status and future prospects
Biomarkers in amyotrophic lateral sclerosis: current status and future prospects
Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug development. Categorization b...
Molecular biomarkers for vascular cognitive impairment and dementia
Molecular biomarkers for vascular cognitive impairment and dementia
As disease-specific interventions for dementia are being developed, the ability to identify the underlying pathology and d...
Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms
Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms
The understanding of idiopathic intracranial hypertension (IIH) has evolved over the past few years. Previously, IIH was c...
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