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Resistance training for the prevention and management of sarcopenia in older adults: Mechanisms, efficacy, and future applications
Sarcopenia is a major health concern in aging populations. Resistance training (RT) is widely recommended to improve muscl...
A dual-pathway model of depression's mediation between chronic pain and dementia
BackgroundAlthough chronic pain is a recognized risk factor for cognitive decline and dementia, often mediated by depressi...
Epidemiological trends, risk factor contributions, and future projections of cardiovascular disease among Chinese adults ≥45 years: insights from GBD 2021 and CHARLS
Amid falling mortality/DALYs, rising CVD incidence/prevalence marks a shift to chronic disease management. Key drivers inc...
Therapeutic potential of Cistanche against Parkinson's disease via regulating circulating inflammation: Insights from Mendelian randomization, molecular docking, and in vivo studies
BackgroundParkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, and no curative treatme...
Construction of a risk prediction model for oral frailty in hospitalized elderly patients with chronic diseases
BackgroundOral frailty is closely associated with systemic health and quality of life in elderly patients, particularly th...
Exploring estrogen synthesis and metabolism related markers and immune dynamics in osteoporosis-insights from single-cell RNA sequencing and Mendelian randomization
BackgroundOsteoporosis (OP) is characterized by decreased bone mineral density and an increased fracture risk, often due t...
Association between dietary carbohydrate-to-fiber ratio and sleep duration among American adults with constipation: A cross-sectional study
Volume 216, April 2026, 113066Author links open overlay panel, , , Highlights•The carbohydrate-to-fiber ratio is independe...
Bidirectional causal associations between immune cell phenotypes and age-related macular degeneration subtypes: A mendelian randomization study
BackgroundAge-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population,...
Epigenetic and hormonal effects of supervised combined aerobic and weight-bearing on bone health in postmenopausal women
BackgroundExercise training is increasingly recognized as a complementary therapy to support skeletal health in postmenopa...
Effect of bedrest on the human gut and oral microbiome: implications for frailty
Volume 216, April 2026, 113079Author links open overlay panel, , , , , Highlights•Inactivity during HDBR led to changes in...
Effects of body composition on age- and sex-related differences in resting metabolic rate from a healthy aging cohort
Resting metabolic rate (RMR) accounts for the majority of the total energy expenditure. While RMR is known to decline with...
Changes in human multifidus muscle size with aging and short-term disuse
Lumbar multifidus (MF) muscle plays a key role in spinal stability, yet its adaptations to aging and disuse, which become ...
Exploration of the co-regulatory mechanism of calorie restriction and endurance exercise on elderly skeletal muscle and its potential intervention targets
This study aims to explore the shared transcriptomic features of caloric restriction (CR) and endurance exercise in skelet...
Genetic associations and mediating effects of insulin resistance between hypertension and sarcopenia: A bidirectional two-sample Mendelian randomization study
ObjectiveHypertension and sarcopenia are major global public health problems among the aging society. This study aims to e...
Atmospherically relevant PM2.5 promotes age-related muscle atrophy in an age-dependent manner
BackgroundMaintaining the quality and function of skeletal muscle in the older adult has become a key topic in successful ...
Daily dietary vitamin C intake and chronic kidney disease prevalence in older adults: NHANES 1999–2018 and nomogram development
ObjectivesTo investigate the association between daily dietary vitamin C intake and chronic kidney disease (CKD) prevalenc...
Obesity metrics and fall severity in older adults: A cross-sectional analysis of weight-adjusted waist index and conventional anthropometric measures
MethodsData from 13,778 adults aged 65 years and older, obtained from the Chinese Longitudinal Healthy Longevity Survey, w...
Exercise training improves mitochondrial oxidative energy metabolism through PGC-1α-dependent transcriptional pathway in the aged rat heart
Exercise training improves the age-induced decline in oxidative metabolic capacity in cardiac mitochondria. Nuclear respir...
Mediterranean diet preserves renal mitochondrial homeostasis and attenuates early diabetic kidney injury in db/db mice
BackgroundChronic hyperglycemia, oxidative stress, and mitochondrial dysfunction are central drivers of renal structural a...
Pain duration as a staging variable: A conceptual framework for testing depression-pathway interventions in dementia risk
This study proposes a conceptual framework for testing the role of pain duration as a staging variable in the relationship...
Cognitive impairment mediates the association between sarcopenic obesity and daily living ability in the frail older population
ObjectiveTo explore the relationships between sarcopenic obesity, cognitive function, and daily living ability in a hospit...
Involvement of the tryptophan-kynurenine pathway in the pathogenesis of autoimmune diseases
AbbreviationsACMSDα-amino-β-carboxymuconate-ε-semialdehyde decarboxylaseAIAadjuvant-induced arthritisAhRaryl hydrocarbon r...
Sustaining neuromuscular activation after total knee arthroplasty preserves skeletal muscle fiber size, contractility, and innervation in older adults
Volume 209, 1 October 2025, 112831Author links open overlay panelMichael J. Toth a b, Patrick D. Savage a, Deena B. Snoke ...
Aerobic exercise preconditioning suppresses subcutaneous tumorigenesis via PI3K/AKT-driven metabolic epigenetic reprogramming and immune microenvironment remodeling
It has been widely recognized that aerobic exercise inhibits tumors, and aerobic glycolysis is closely related to tumor de...
Mild cognitive impairment among older adults in outpatient clinics: Awareness and knowledge needs survey
ObjectiveThe aim of this study was to assess the current awareness and knowledge requirements related to mild cognitive im...
Fall history and risk of incident stroke in middle-aged and older adults with possible sarcopenia: A longitudinal cohort study based on CHARLS
BackgroundPossible sarcopenia (PS) was defined per AWGS 2019 criteria as reduced muscle strength or physical performance w...
Acupuncture modulates ovarian senescence through metabolic reprogramming: A multi-omics investigation in chemotherapy - induced POF model
Premature ovarian failure (POF) is a common female endocrine disorder in women, and there is currently no effective pharma...
ATF3 as a molecular nexus linking ferroptosis regulation to sarcopenia pathogenesis via PI3K/Akt pathway activation
PurposeSarcopenia, characterized by progressive skeletal muscle loss and weakness, has unclear pathogenesis and lacks targ...
Single nucleotide polymorphism SULT2A1 rs4149448 and genetic risk score as biomarkers of frailty and progression of chronic kidney disease
BackgroundFrailty is a multifactorial condition highly prevalent in patients with chronic kidney disease (CKD), increasing...
Effects of unstable resistance training combined with high-definition transcranial direct current stimulation on proprioception, balance and fall risks in the elderly: a randomized controlled trial study
First study demonstrating that an 8-week dual-pathway intervention (HD-tDCS over M1 + unstable resistance training) synerg...
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