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Angiotensin II induces sex-specific ventricular remodeling in aging C57Bl/6 mice
Angiotensin II induces sex-specific ventricular remodeling in aging C57Bl/6 mice
Renin-angiotensin system (RAS) activation in heart failure (HF) increases circulating angiotensin II (AII). This increases...
Germline regulation of the intestinal mitochondrial unfolded protein response
Germline regulation of the intestinal mitochondrial unfolded protein response
The disposable soma theory posits that there is a trade-off between reproduction and somatic maintenance. In support of th...
Characterizing motoric cognitive risk syndrome beyond traditional criteria
Characterizing motoric cognitive risk syndrome beyond traditional criteria
Motoric cognitive risk (MCR) syndrome is defined by slow gait speed and cognitive complaints. This study aimed to identify...
Association of muscle mass and strength with blood-based epigenetic aging among middle-aged and older adults in the United States
Association of muscle mass and strength with blood-based epigenetic aging among middle-aged and older adults in the United States
Muscle mass and strength influence various age-related health outcomes, however their individual and joint associations wi...
The combined association between sleep duration and insomnia symptoms with dementia and cognitive deficits: a multivariable-adjusted and genetic liability study
The combined association between sleep duration and insomnia symptoms with dementia and cognitive deficits: a multivariable-adjusted and genetic liability study
Insomnia symptoms in combination with extreme habitual sleep durations may be associated with long-term dementia incidence...
The effects of ageing on fatigue and endurance of the spinal extensor muscles: a systematic review and meta-analysis
The effects of ageing on fatigue and endurance of the spinal extensor muscles: a systematic review and meta-analysis
The endurance capacity of the spinal extensor muscles plays a key role in maintaining spinal function. This systematic rev...
Open problems in ageing science: a roadmap for biogerontology
Open problems in ageing science: a roadmap for biogerontology
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain ...
Low intrinsic capacity is associated with risk of developing mild cognitive impairment in the English Longitudinal Study of Ageing (ELSA)
Low intrinsic capacity is associated with risk of developing mild cognitive impairment in the English Longitudinal Study of Ageing (ELSA)
Intrinsic capacity (IC) is a composite that includes five different domains related to a person’s capacities: sensor...
Longitudinal changes in epigenetic measures over 2 years: methodological implications
Longitudinal changes in epigenetic measures over 2 years: methodological implications
Epigenetic clocks are increasingly proposed as surrogate endpoints in aging trials, yet their short-term behavior in healt...
Subjective memory and 5-year all-cause mortality in subjective cognitive decline, non-amnestic mild cognitive impairment, and amnestic mild cognitive impairment
Subjective memory and 5-year all-cause mortality in subjective cognitive decline, non-amnestic mild cognitive impairment, and amnestic mild cognitive impairment
Cognitive decline is becoming increasingly prevalent, and dementia diseases are currently the seventh leading cause of dea...
Greater prefrontal cortical activation is associated with higher balance confidence in older adults
Greater prefrontal cortical activation is associated with higher balance confidence in older adults
Fear of falling (FoF) is a prevalent and consequential concern among older adults, often associated with impaired mobility...
Longitudinal transitions in sedentary behavior and physical activity in relation to all-cause and cause-specific mortality among postmenopausal women
Longitudinal transitions in sedentary behavior and physical activity in relation to all-cause and cause-specific mortality among postmenopausal women
To evaluate longitudinal transitions in sedentary behavior and physical activity for the associations with all-cause and c...
Widespread neuronal hemokinin-1 expression in motor regions and its protective role in age-related impairment
Widespread neuronal hemokinin-1 expression in motor regions and its protective role in age-related impairment
Hemokinin-1 (HK-1) regulates several processes in the central and peripheral nervous systems, including musculoskeletal fu...
Life-extending interventions do not necessarily result in compression of morbidity: a case example offering a robust statistical approach
Life-extending interventions do not necessarily result in compression of morbidity: a case example offering a robust statistical approach
Despite extensive research on life-extending interventions, rigorous statistical techniques to determine their impact on c...
An integrated multi-algorithm analysis to decipher senescence and metabolic characteristics in nucleus pulposus cells during disc degeneration
An integrated multi-algorithm analysis to decipher senescence and metabolic characteristics in nucleus pulposus cells during disc degeneration
Accumulating evidence has suggested that intervertebral disc degeneration (IVDD) serves as a health problem deserving atte...
Single-cell transcriptomic analysis reveals immune remodeling in bone marrow during aged sepsis
Single-cell transcriptomic analysis reveals immune remodeling in bone marrow during aged sepsis
Aging substantially increases susceptibility to sepsis, yet the underlying mechanisms of immune dysfunction in the elderly...
Loss of molecular resilience as the ultimate outcome of aging biology
Loss of molecular resilience as the ultimate outcome of aging biology
We have discussed progressive deterioration of overall health as the defining aspect of the aging process, distinct from d...
Heavy alcohol use exacerbates skeletal myopathy in peripheral artery disease
Heavy alcohol use exacerbates skeletal myopathy in peripheral artery disease
Peripheral artery disease (PAD) is an age-associated vascular condition that contributes to progressive skeletal muscle dy...
HomeCoRe for telerehabilitation in mild or major neurocognitive disorders: a non-inferiority randomized controlled trial
HomeCoRe for telerehabilitation in mild or major neurocognitive disorders: a non-inferiority randomized controlled trial
This randomized controlled trial (RCT) assessed the non-inferiority of HomeCoRe, a home-based version of the CoRe (Cogniti...
Age-related changes in adrenergic regulation of contractility and redox status of glycolytic and oxidative skeletal muscles
Age-related changes in adrenergic regulation of contractility and redox status of glycolytic and oxidative skeletal muscles
Aging is associated with skeletal muscle weakness and oxidative stress. Here, we hypothesized that aging may lead to alter...
Effect of acipimox on skeletal muscle biochemistry, structure and function in older people with probable sarcopenia: an experimental medicine study
Effect of acipimox on skeletal muscle biochemistry, structure and function in older people with probable sarcopenia: an experimental medicine study
Skeletal muscle nicotinamide adenine dinucleotide (NAD) concentrations are low in people with sarcopenia. Increasing NAD c...
An incidental finding during a brain plasticity study: substantial telomere length shortening after COVID-19 lockdown in the older population
An incidental finding during a brain plasticity study: substantial telomere length shortening after COVID-19 lockdown in the older population
The detrimental effects of lockdowns have already been proven by numerous studies, mainly using psychometric measurements....
Insomnia accelerates the epigenetic clocks in older adults
Insomnia accelerates the epigenetic clocks in older adults
Insomnia is a common sleep disorder characterized mainly by poor sleep quality and insufficient sleep duration. It affects...
Age-related alterations of angiogenesis, inflammation and bone microarchitecture during fracture healing in mice
Age-related alterations of angiogenesis, inflammation and bone microarchitecture during fracture healing in mice
The surgical treatment of geriatric patients represents a major challenge in traumatology. It is well known that aging aff...
Chronic alcohol consumption accelerates cardiovascular aging and decreases cardiovascular reserve capacity
Chronic alcohol consumption accelerates cardiovascular aging and decreases cardiovascular reserve capacity
The pathology of cardiovascular aging is complex, involving mitochondrial dysfunction, oxidative and nitrative stress, oxi...
Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?
Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?
Vascular cognitive impairment (VCI) is a leading cause of age-related cognitive decline, driven by cerebrovascular dysfunc...
Cortical adaptations in regional activity and backbone network following short-term postural training with visual feedback for older adults
Cortical adaptations in regional activity and backbone network following short-term postural training with visual feedback for older adults
This study investigated cortical reorganization in older adults following short-term interactive balance training. Twenty ...
Correction to: White matter lipid alterations during aging in the rhesus monkey brain
Correction to: White matter lipid alterations during aging in the rhesus monkey brain
Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, 72 East Concord ...
Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral blood flow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain
Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral blood flow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain
Chemotherapy-induced cognitive impairment (CICI), often referred to as “chemobrain,” significantly affects the...
Innovative approaches in the treatment-resistant depression: exploring different therapeutic pathways
Innovative approaches in the treatment-resistant depression: exploring different therapeutic pathways
Treatment-resistant depression (TRD) remains a vital challenge in psychiatry, affecting a significant number of patients w...
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