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Psychosocial adversity captured by ICD-10 Z-codes and mortality risk: evidence from the UK Biobank
Psychosocial adversity captured by ICD-10 Z-codes and mortality risk: evidence from the UK Biobank
Psychosocial adversity is a major determinant of health, but the mortality associations of its clinical documentation via ...
Telomere length and appendicular lean mass over six years in older adults with overweight or obesity and metabolic syndrome: a prospective cohort study
Telomere length and appendicular lean mass over six years in older adults with overweight or obesity and metabolic syndrome: a prospective cohort study
Telomere length (TL) has been proposed as a marker of appendicular lean mass (ALM) decline; however, longitudinal...
Resting heart rate and cognitive function in ageing: Insights from a secondary data analysis
Resting heart rate and cognitive function in ageing: Insights from a secondary data analysis
Resting heart rate (RHR) is an accessible measure that may reflect age-related cardiovascular and autonomic dysregulation ...
Age-related metabolomic signatures and stroke susceptibility in a population-based cohort
Age-related metabolomic signatures and stroke susceptibility in a population-based cohort
Aging-related metabolic dysregulation and vascular vulnerability contribute substantially to stroke susceptibility, yet su...
Association between atrial fibrillation and systemic inflammation with muscle mass and strength trajectories in old age
Association between atrial fibrillation and systemic inflammation with muscle mass and strength trajectories in old age
The long-term impact of atrial fibrillation (AF) and systemic inflammation on muscle health and, hence, functional decline...
Space radiation and microgravity as models of accelerated aging: modulation of hepatic miRNA-TGF-β networks associated with senescence and fibrosis
Space radiation and microgravity as models of accelerated aging: modulation of hepatic miRNA-TGF-β networks associated with senescence and fibrosis
Future deep-space missions will expose astronauts to microgravity and ionizing radiation, which induce molecular changes t...
Machine learning derived abdominal aortic calcification is associated with physical frailty in community-dwelling adults: the UK Biobank Imaging Study
Machine learning derived abdominal aortic calcification is associated with physical frailty in community-dwelling adults: the UK Biobank Imaging Study
Clinical cardiovascular disease (CVD) is often present in frail individuals. However, it remains unclear whether subclinic...
Exploring the association between common genetic deletions and aging: insights from the Canadian Longitudinal Study on Aging
Exploring the association between common genetic deletions and aging: insights from the Canadian Longitudinal Study on Aging
Germline deletions of UDP-glycosyltransferase (UGT) UGT2B17 and UGT2B28 genes are common in human populations, yet their a...
Exploratory plasma metabolomics of aging-related associations with muscle quality and pulmonary function
Exploratory plasma metabolomics of aging-related associations with muscle quality and pulmonary function
Aging is accompanied by metabolic alterations that may precede or parallel functional decline. While chronological age cor...
Associations of daily step counts with cognitive, clinical, and resting-state electroencephalographic measures in patients with cognitive decline due to Alzheimer’s disease
Associations of daily step counts with cognitive, clinical, and resting-state electroencephalographic measures in patients with cognitive decline due to Alzheimer’s disease
Sedentary behavior is a recognized and modifiable risk factor for cognitive decline and dementia across neurodegenerative ...
Age-adjusted leukocyte telomere length predicts long-term mortality in older patients discharged from acute care hospitals
Age-adjusted leukocyte telomere length predicts long-term mortality in older patients discharged from acute care hospitals
Leukocyte telomere length (LTL) is a widely studied biomarker of biological aging, reflecting cumulative cellular damage b...
Unraveling physical performance over time in hospitalized older patients with walking limitation: the role of ultrasound-derived vastus lateralis muscle thickness
Unraveling physical performance over time in hospitalized older patients with walking limitation: the role of ultrasound-derived vastus lateralis muscle thickness
Acute hospitalization is a critical stressor that often leads to functional decline in older patients, highlighting the ne...
Gut microbiota profiles across intrinsic capacity strata in community-dwelling older adults using full-length 16S rRNA sequencing
Gut microbiota profiles across intrinsic capacity strata in community-dwelling older adults using full-length 16S rRNA sequencing
Intrinsic capacity (IC), introduced by the World Health Organization, provides a multidimensional framework for evaluating...
Quantitative Cellular AGing Evaluation system (qCAGEs): a dual-parameter platform for high-throughput senescence screening
Quantitative Cellular AGing Evaluation system (qCAGEs): a dual-parameter platform for high-throughput senescence screening
Accurate identification and quantification of senescence-modulating compounds require screening platforms that can disting...
Plasma proteins associated with disability and mortality risks in Japanese community-dwelling octogenarians
Plasma proteins associated with disability and mortality risks in Japanese community-dwelling octogenarians
Japan has one of the world’s longest life expectancies, yet biomarkers associated with disability and mortality in v...
The shaky voice of aging localized to the larynx: dissociation of frequency and amplitude tremor
The shaky voice of aging localized to the larynx: dissociation of frequency and amplitude tremor
Aging is associated with structural and functional changes of the vocal folds that may result in presbyphonia, often perce...
Study protocol for FAXAge: a randomized, controlled clinical trial of fasting and exercise to slow aging in humans
Study protocol for FAXAge: a randomized, controlled clinical trial of fasting and exercise to slow aging in humans
Biomarkers of aging, particularly DNA methylation-based clocks, have shown promise as tools to assess whether intervention...
Long-term intake of statins or renin-angiotensin system inhibitors: associations with sarcopenia-related parameters in older people
Long-term intake of statins or renin-angiotensin system inhibitors: associations with sarcopenia-related parameters in older people
The long-term impact of common cardiovascular medications on sarcopenia in older people is unclear. The objective was to i...
Age-related differences in motor unit discharge rate modulation across contraction levels
Age-related differences in motor unit discharge rate modulation across contraction levels
Age-related strength loss may reflect morphological and neural adaptations that differ between muscles. However, it is unc...
The influence of aging on graded peripheral venous return and complex blood flow features through human veins
The influence of aging on graded peripheral venous return and complex blood flow features through human veins
Aging is associated with reduced venous compliance and altered muscle pump function, though how these features impact veno...
Angiotensin II induces sex-specific ventricular remodeling in aging C57Bl/6 mice
Angiotensin II induces sex-specific ventricular remodeling in aging C57Bl/6 mice
Renin-angiotensin system (RAS) activation in heart failure (HF) increases circulating angiotensin II (AII). This increases...
Germline regulation of the intestinal mitochondrial unfolded protein response
Germline regulation of the intestinal mitochondrial unfolded protein response
The disposable soma theory posits that there is a trade-off between reproduction and somatic maintenance. In support of th...
Characterizing motoric cognitive risk syndrome beyond traditional criteria
Characterizing motoric cognitive risk syndrome beyond traditional criteria
Motoric cognitive risk (MCR) syndrome is defined by slow gait speed and cognitive complaints. This study aimed to identify...
Association of muscle mass and strength with blood-based epigenetic aging among middle-aged and older adults in the United States
Association of muscle mass and strength with blood-based epigenetic aging among middle-aged and older adults in the United States
Muscle mass and strength influence various age-related health outcomes, however their individual and joint associations wi...
The combined association between sleep duration and insomnia symptoms with dementia and cognitive deficits: a multivariable-adjusted and genetic liability study
The combined association between sleep duration and insomnia symptoms with dementia and cognitive deficits: a multivariable-adjusted and genetic liability study
Insomnia symptoms in combination with extreme habitual sleep durations may be associated with long-term dementia incidence...
The effects of ageing on fatigue and endurance of the spinal extensor muscles: a systematic review and meta-analysis
The effects of ageing on fatigue and endurance of the spinal extensor muscles: a systematic review and meta-analysis
The endurance capacity of the spinal extensor muscles plays a key role in maintaining spinal function. This systematic rev...
Open problems in ageing science: a roadmap for biogerontology
Open problems in ageing science: a roadmap for biogerontology
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain ...
Low intrinsic capacity is associated with risk of developing mild cognitive impairment in the English Longitudinal Study of Ageing (ELSA)
Low intrinsic capacity is associated with risk of developing mild cognitive impairment in the English Longitudinal Study of Ageing (ELSA)
Intrinsic capacity (IC) is a composite that includes five different domains related to a person’s capacities: sensor...
Longitudinal changes in epigenetic measures over 2 years: methodological implications
Longitudinal changes in epigenetic measures over 2 years: methodological implications
Epigenetic clocks are increasingly proposed as surrogate endpoints in aging trials, yet their short-term behavior in healt...
Subjective memory and 5-year all-cause mortality in subjective cognitive decline, non-amnestic mild cognitive impairment, and amnestic mild cognitive impairment
Subjective memory and 5-year all-cause mortality in subjective cognitive decline, non-amnestic mild cognitive impairment, and amnestic mild cognitive impairment
Cognitive decline is becoming increasingly prevalent, and dementia diseases are currently the seventh leading cause of dea...
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