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Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study
Immunosenescence, the gradual deterioration of the immune system, is critical for aging-related diseases. However, the lac...
Delayed viral clearance and altered inflammatory responses affect severity of SARS-CoV-2 infection in aged mice
Delayed viral clearance and altered inflammatory responses affect severity of SARS-CoV-2 infection in aged mice
Epidemiological investigations consistently demonstrate an overrepresentation of the elderly in COVID-19 hospitalizations ...
Enhancing flu vaccine responses in older adults: preliminary insights from the ISOLDA study on immunosenescence and antioxidant and anti-inflammatory approaches
Enhancing flu vaccine responses in older adults: preliminary insights from the ISOLDA study on immunosenescence and antioxidant and anti-inflammatory approaches
Aging is frequently characterized by an inadequate primary vaccine response, likely due to immunosenescence and inflamm-ag...
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination
Ageing-associated remodeling of the murine B cell system is accompanied with a reduction of CD19+ B cells such as follicul...
Chronic IL-21 drives neuroinflammation and promotes lipid accumulation in microglia
Chronic IL-21 drives neuroinflammation and promotes lipid accumulation in microglia
Neuroinflammation is a key contributor to the onset and progression of neurodegenerative diseases, driven by factors such ...
Impact of NAD+ metabolism on ovarian aging
Impact of NAD+ metabolism on ovarian aging
Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox reactions, is closely associated with age-r...
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remai...
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T...
Frailty is related to serum inflammageing markers: results from the VITAL study
Frailty is related to serum inflammageing markers: results from the VITAL study
Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adver...
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway
CircZBTB46 has been identified as being associated with the risk of coronary artery disease (CAD) and has the potential to...
Toll-like receptor 4 (TLR4): new insight immune and aging
Toll-like receptor 4 (TLR4): new insight immune and aging
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous l...
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions
Neovascular age-related macular degeneration (nAMD) is a major cause of blindness in the elderly. The disease is due to th...
Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly
Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly
The spaceflight environment is an extreme environment that affects the immune system of approximately 50% of astronauts. W...
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease...
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
About 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months ...
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome
Aging is a biological event that influences many organs and systems. Both sarcopenia and frailty syndrome refer to geriatr...
A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence
A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence
The aging lung is a complex process and influenced by various stressors, especially airborne pathogens and xenobiotics. Ad...
TBX21, the Master regulator of the type 1 immune response, overexpresses in the leukocytes of peripheral blood in patients with late-onset Alzheimer’s disease
TBX21, the Master regulator of the type 1 immune response, overexpresses in the leukocytes of peripheral blood in patients with late-onset Alzheimer’s disease
The involvement of the peripheral immune system in the etiology of neurodegenerative diseases has recently been emphasized...
Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study
Immune responses to vaccination vary widely between individuals. The aim of this study was to identify health-related vari...
Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways
Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways
Sarcopenia is closely associated with gut dysbiosis. Probiotics alleviate gut dysbiosis. Therefore, we selected probiotics...
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic co...
Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health
Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health
Increased age is a risk factor for the development and progression of retinal diseases including age-related macular degen...
Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients
Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients
Age-associated deterioration of the immune system contributes to a chronic low-grade inflammatory state known as “in...
Decoding the immune landscape following hip fracture in elderly patients: unveiling temporal dynamics through single-cell RNA sequencing
Decoding the immune landscape following hip fracture in elderly patients: unveiling temporal dynamics through single-cell RNA sequencing
Hip fractures in the elderly have significant consequences, stemming from the initial trauma and subsequent surgeries. Hid...
Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis
Obesity drives adipose-derived stem cells into a senescent and dysfunctional phenotype associated with P38MAPK/NF-KB axis
Adipose-derived stem cells (ADSC) are multipotent cells implicated in tissue homeostasis. Obesity represents a chronic inf...
Transcriptional characteristics and functional validation of three monocyte subsets during aging
Transcriptional characteristics and functional validation of three monocyte subsets during aging
Age-associated changes in immunity are inextricably linked to chronic inflammation and age-related diseases, the impact of...
Towards a better preclinical cancer model – human immune aging in humanized mice
Towards a better preclinical cancer model – human immune aging in humanized mice
Preclinical models are often used for cancer studies and evaluation of novel therapeutics. The relevance of these models h...
Related factors of renal injury in primary Sjögren's syndrome
Related factors of renal injury in primary Sjögren's syndrome
Primary Sjögren’s syndrome (pSS) is a common chronic systemic autoimmune disorder which primarily affects the e...
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