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The anticancer thiosemicarbazone triapine exerts immune-enhancing activities via immunogenic cell death induction and FAS upregulation
The anticancer thiosemicarbazone triapine exerts immune-enhancing activities via immunogenic cell death induction and FAS upregulation
The anticancer thiosemicarbazone Triapine is currently in a phase III clinical trial in combination with radiation therapy...
Improving CAR-T cell function through a targeted cytokine delivery system utilizing car target-modified extracellular vesicles
Improving CAR-T cell function through a targeted cytokine delivery system utilizing car target-modified extracellular vesicles
Chimeric antigen receptor (CAR)-T-cell therapy has achieved remarkable clinical success in the treatment of B-cell maligna...
Extracellular matrix stiffness reduces DNA 6 ma level to facilitate colorectal cancer progression via disrupting P53 binding to CDKN1A promoter
Extracellular matrix stiffness reduces DNA 6 ma level to facilitate colorectal cancer progression via disrupting P53 binding to CDKN1A promoter
The extracellular matrix (ECM) forms the primary scaffold of the tumor microenvironment, with matrix stiffness serving as ...
IL-7-PD-L1 nano-antibody mediated “zipper” effect augments the tumoricidal activity of tumor-infiltrating lymphocytes
IL-7-PD-L1 nano-antibody mediated “zipper” effect augments the tumoricidal activity of tumor-infiltrating lymphocytes
Cancer represents a pressing global health concern, characterized by a substantial number of unmet clinical needs. Cell th...
Overall survival of recurrent/metastatic head & neck squamous cell carcinoma patients progressing after ≥ 1 line of systemic therapy, treated with MVX-ONCO-1, a novel, first in class cell encapsulation-based immunotherapy: results of SAKK 11/16, a phase IIa trial
Overall survival of recurrent/metastatic head & neck squamous cell carcinoma patients progressing after ≥ 1 line of systemic therapy, treated with MVX-ONCO-1, a novel, first in class cell encapsulation-based immunotherapy: results of SAKK 11/16, a phase IIa trial
Over the past two decades, most cancer vaccines have failed to be developed clinically. The lack of efficient priming with...
Prominent efficacy and good safety of sequential CD19 and CD22 CAR-T therapy in relapsed/refractory adult B-cell acute lymphoblastic leukemia
Prominent efficacy and good safety of sequential CD19 and CD22 CAR-T therapy in relapsed/refractory adult B-cell acute lymphoblastic leukemia
Sequential CD19 and CD22 chimeric antigen receptor (CAR)-T cell therapy offers a promising approach to antigen-loss relaps...
A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinoma
A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinoma
Osimertinib has emerged as a critical element in the treatment landscape following recent clinical trials. Further investi...
Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications
Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications
Immune checkpoint therapies have spearheaded drug innovation over the last decade, propelling cancer treatments toward a n...
Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Radiotherapy is the primary treatment modality for most head and neck cancers (HNCs). Despite the addition of chemotherapy...
Construction and characterization of chimeric FcγR T cells for universal T cell therapy
Construction and characterization of chimeric FcγR T cells for universal T cell therapy
Several approaches are being explored for engineering off-the-shelf chimeric antigen receptor (CAR) T cells. In this study...
The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment
The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment
Pyroptosis, an inflammatory programmed cell death, distinguishes itself from apoptosis and necroptosis and has drawn incre...
Antitumor effect of a small-molecule inhibitor of KRASG12D in xenograft models of mucinous appendicular neoplasms
Antitumor effect of a small-molecule inhibitor of KRASG12D in xenograft models of mucinous appendicular neoplasms
Pseudomyxoma peritonei (PMP) is a rare disease characterized by a massive accumulation of mucus in the peritoneal...
A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease
A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease
Differentiating between pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CCA) is crucial for the appropriat...
Upregulated PARP1 confers breast cancer resistance to CDK4/6 inhibitors via YB-1 phosphorylation
Upregulated PARP1 confers breast cancer resistance to CDK4/6 inhibitors via YB-1 phosphorylation
Cyclic-dependent kinase (CDK) 4/6 kinases, as the critical drivers of the cell cycle, are involved in the tumor progressio...
Immune checkpoint inhibitors for multiple myeloma immunotherapy
Immune checkpoint inhibitors for multiple myeloma immunotherapy
Multiple myeloma (MM) is related to immune disorders, recent studys have revealed that immunotherapy can greatly benefit M...
Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates
Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates
Being stimulated by the chemokine CXCL12, the CXCR4 / CXCR7 cascade is involved in tumor proliferation, ...
Single VHH-directed BCMA CAR-NK cells for multiple myeloma
Single VHH-directed BCMA CAR-NK cells for multiple myeloma
Natural killer (NK) cells are promising alternatives for the production of “off-the-shelf” CAR products, posin...
Deciphering tumor-infiltrating dendritic cells in the single-cell era
Deciphering tumor-infiltrating dendritic cells in the single-cell era
Dendritic cells (DCs) serve as a pivotal link connecting innate and adaptive immunity by processing tumor-derived antigens...
The current landscape of using direct inhibitors to target KRASG12C-mutated NSCLC
The current landscape of using direct inhibitors to target KRASG12C-mutated NSCLC
Mutation in KRAS protooncogene represents one of the most common genetic alterations in NSCLC and has posed a great therap...
Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling
Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling
Recurrence is one of the main causes of treatment failure in early-stage non-small cell lung cancer (NSCLC). However, ther...
CRISPR/Cas9 system: recent applications in immuno-oncology and cancer immunotherapy
CRISPR/Cas9 system: recent applications in immuno-oncology and cancer immunotherapy
Clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) is essentially an a...
Chinese expert consensus on Bruton tyrosine kinase inhibitors in the treatment of B-cell malignancies
Chinese expert consensus on Bruton tyrosine kinase inhibitors in the treatment of B-cell malignancies
Targeted therapy with Bruton tyrosine kinase (BTK) inhibitors have revolutionized the treatment of patients with various B...
New insight into circRNAs: characterization, strategies, and biomedical applications
New insight into circRNAs: characterization, strategies, and biomedical applications
Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most circRNAs are derived from exonic or int...
Targeting CD22 for B-cell hematologic malignancies
Targeting CD22 for B-cell hematologic malignancies
CD19-targeted chimeric receptor antigen (CAR)-T cell therapy has shown remarkable clinical efficacy in the treatment of re...
CRISPR/Cas9-mediated knockout of intracellular molecule SHP-1 enhances tumor-killing ability of CD133-targeted CAR T cells in vitro
CRISPR/Cas9-mediated knockout of intracellular molecule SHP-1 enhances tumor-killing ability of CD133-targeted CAR T cells in vitro
CAR T cell therapy has been successfully used in the treatment of hematological malignancies, and the strategy that deleti...
Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia
Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia
Impaired neutrophil activity is an important issue in chronic lymphocytic leukemia (CLL), as it contributes to a dysfuncti...
Correction to: Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting
Correction to: Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Identification of a novel NPM1 mutation in acute myeloid leukemia
Identification of a novel NPM1 mutation in acute myeloid leukemia
Nucleophosmin (NPM1) is a widely expressed nucleocytoplasmic shuttling protein with prominent nucleolar localization. It i...
Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain
Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain
Immunosuppression induced by programmed cell death protein 1 (PD1) presents a significant constraint on the effectiveness ...
Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target
Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target
Immunotherapy has emerged as an effective treatment for various types of cancers. Recent studies have highlighted a signif...
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