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The influence of genetic variation on late effects in childhood cancer survivors: An updated systematic review

Over the past decades, childhood cancer survival rates have increased significantly due to an enhanced understanding of ca...

Critical Reviews In Oncology Hematology

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Individual radiosensitivity testing in 2025: Current advances and future directions for personalized radiotherapy

Radiation therapy (RT) is a cornerstone of modern oncology, with approximately 60 % of cancer patients receiving RT during...

Critical Reviews In Oncology Hematology

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Gut microbiota and chemoradiotherapy response in rectal cancer: Biomarker opportunities

Christophe Taoum, MD, PhD. Surgical oncologist at the Montpellier Cancer Institute (ICM), France. PhD in collaboration wit...

Critical Reviews In Oncology Hematology

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Molecular landscape of colorectal cancer liver metastasis: Tumor microenvironment heterogeneity and driver inference

Colorectal cancer is one of the most common malignancies worldwide. As of 2024, the incidence and mortality rates of CRC c...

Critical Reviews In Oncology Hematology

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Decoding optic pathway gliomas: Molecular insights and emerging therapies

Shepeng Wei is the chief of the Department of Neurosurgery at Shidong Hospital, Shanghai, China, where he also serves as c...

Critical Reviews In Oncology Hematology

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Biomarkers in blood and saliva to screen fragile patients with solid tumors: A systematic review of the literature

Univ. Prof. Dr. med. Annette Hasenburg, MD, Director of the Clinic and Polyclinic for Obstetrics and Women's Health, exper...

Critical Reviews In Oncology Hematology

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Immune evasion in endometrial cancer: Unraveling the latest mechanisms and future directions

Endometrial cancer (EC) is the third most common malignancy in women worldwide, with an estimated 420,000 new cases diagno...

Critical Reviews In Oncology Hematology

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Dynamic interplay of neuroendocrine signaling and immuno-surveillance in tumor niche remodeling

The nervous system has a dual role in regulating the immune system. It detects and processes stimuli and directly influenc...

Critical Reviews In Oncology Hematology

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Impact of exercise in patients with pancreatic cancer across different treatment phases: A systematic review

Salvatore Paiella, MD, Ph.D, Associate Professor at the General and Pancreatic Surgery Unit of the Pancreas Institute of t...

Critical Reviews In Oncology Hematology

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Tenosynovial giant cell tumor (TGCT): Mechanisms and advances in targeted treatments

Volume 216, December 2025, 104951Author links open overlay panel, , , , Highlights•TGCT in the joints and tendon sheaths n...

Critical Reviews In Oncology Hematology

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Maintenance after first-line treatment for advanced soft tissue sarcoma

Soft tissue sarcomas (STS) include over 100 different biopathological entities, representing less than 2 % of all cancers ...

Critical Reviews In Oncology Hematology

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Dynamic crosstalk between tumor-associated macrophages and cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

PDAC is a highly aggressive malignancy with an extremely poor prognosis, exhibiting a 5-year survival rate of less than 10...

Critical Reviews In Oncology Hematology

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Artificial intelligence enabled tumor diagnosis and treatment: Status, breakthroughs and challenges

Cancer remains one of the most pressing global public health challenges, constituting a primary cause of mortality globall...

Critical Reviews In Oncology Hematology

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Guidelines for the prevention and diagnosis of vaginal and vulvar cancers: A systematic review

Volume 216, December 2025, 104970Author links open overlay panel, , Highlights•Numerous guidelines are available for vagin...

Critical Reviews In Oncology Hematology

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Molecular insights into the role of tumor-specific endothelial cells in metastasis

Metastasis denotes the mechanism via which cancer cells disseminate from the main tumor to remote organs, signifying a piv...

Critical Reviews In Oncology Hematology

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Adjuvant immunotherapy in high-risk renal cell carcinoma: Indications, limitations, and perspectives. A consensus statement from the GIOTTO uro-oncology group

Critical Reviews In Oncology Hematology

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Bystander effect in antibody-drug conjugates: Navigating the fine line in tumor heterogeneity

Cytotoxic chemicals have been a cornerstone of cancer treatment for nearly a century. However, their clinical utility rema...

Critical Reviews In Oncology Hematology

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Chromophobe renal cell carcinoma: Emerging vulnerabilities as a promise for a new therapeutic landscape

Chromophobe RCC (ChRCC) was first described by Thoenes et al. in 1985 (Thoenes et al., 1985) and is the third most common ...

Critical Reviews In Oncology Hematology

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Artificial intelligence in NSCLC management for revolutionizing diagnosis, prognosis, and treatment optimization: A systematic review

Non-small cell lung cancer (NSCLC) accounts for approximately 85 % of all lung cancer cases and remains a leading cause of...

Critical Reviews In Oncology Hematology

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Survival outcomes with enfortumab vedotin–containing regimens in metastatic urothelial carcinoma: A systematic review and meta-analysis

Urothelial carcinoma is a widely prevalent malignancy, ranking as the ninth most commonly occurring neoplasia across the w...

Critical Reviews In Oncology Hematology

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Endocrinological toxicities related to immunotherapy combinations for advanced renal cell carcinoma: Practical expert-based management recommendations