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Architecture of torovirus replicative organelles
Architecture of torovirus replicative organelles
Summary Plus-stranded RNA viruses replicate in the cytosol of infected cells, in membrane-bound replication complexes. We ...
Escherichia coli SymE is a DNA‐binding protein that can condense the nucleoid
Escherichia coli SymE is a DNA‐binding protein that can condense the nucleoid
Abstract Type I toxin-antitoxin (TA) systems typically consist of a protein toxin that imbeds in the inner membrane where ...
BldD‐based bimolecular fluorescence complementation for in vivo detection of the second messenger cyclic di‐GMP
BldD‐based bimolecular fluorescence complementation for in vivo detection of the second messenger cyclic di‐GMP
Abstract The widespread bacterial second messenger bis-(3'-5')-cyclic diguanosine monophosphate (c-di-GMP) is an important...
Rotavirus activates MLKL‐mediated host cellular necroptosis concomitantly with apoptosis to facilitate dissemination of viral progeny
Rotavirus activates MLKL‐mediated host cellular necroptosis concomitantly with apoptosis to facilitate dissemination of viral progeny
SUMMARY Reprogramming the host cellular environment is an obligatory facet of viral pathogens to foster their replication ...
Persistence of Trypanosoma brucei as early procyclic forms and social motility are dependent on glycosylphosphatidylinositol transamidase
Persistence of Trypanosoma brucei as early procyclic forms and social motility are dependent on glycosylphosphatidylinositol transamidase
Summary Glycosylphosphatidylinositol (GPI)-linked molecules are surface-exposed membrane components that influence the inf...
Escherichia coli induces DNA repair enzymes to protect itself from low‐grade hydrogen peroxide stress
Escherichia coli induces DNA repair enzymes to protect itself from low‐grade hydrogen peroxide stress
Abstract E. coli responds to hydrogen peroxide (H2O2) by inducing defenses that protect H2O2-sensitive enzymes. DNA is bel...
Genomic and phenotypic analysis of SspH1 identifies a new Salmonella effector, SspH3
Genomic and phenotypic analysis of SspH1 identifies a new Salmonella effector, SspH3
Abstract Salmonella is a major foodborne pathogen and is responsible for a range of diseases. Not all Salmonella contribut...
PATAN‐domain regulators interact with the Type IV pilus motor to control phototactic orientation in the cyanobacterium Synechocystis
PATAN‐domain regulators interact with the Type IV pilus motor to control phototactic orientation in the cyanobacterium Synechocystis
Abstract Many prokaryotes show complex behaviors that require the intricate spatial and temporal organization of cellular ...
FabR senses long chain unsaturated fatty acids to control virulence in pathogen Edwardsiella piscicida
FabR senses long chain unsaturated fatty acids to control virulence in pathogen Edwardsiella piscicida
Abstract Long-chain unsaturated fatty acids (UFAs) can serve as nutrient sources or building blocks for bacterial membrane...
Non‐classical autophagy activation pathways are essential for production of infectious Influenza A virus in vitro
Non‐classical autophagy activation pathways are essential for production of infectious Influenza A virus in vitro
Abstract Autophagy is a critical mechanism deployed by eukaryotic cells in response to stress, including viral infection, ...
Impairment of lysosomal function by Clostridioides difficile TcdB
Impairment of lysosomal function by Clostridioides difficile TcdB
Abstract TcdB is a potent cytotoxin produced by pathogenic Clostridioides difficile that inhibits Rho GTPases by mono-gluc...
Carbon Catabolite Repression on the Rgg2/3 Quorum Sensing System in Streptococcus pyogenes is Mediated by PTSMan and Mga
Carbon Catabolite Repression on the Rgg2/3 Quorum Sensing System in Streptococcus pyogenes is Mediated by PTSMan and Mga
Summary Streptococcus pyogenes, also known as Group A Streptococcus or GAS, is a human-restricted pathogen causing a diver...
Activity modulation of anti‐sigma factor via cysteine alkylation in Actinobacteria
Activity modulation of anti‐sigma factor via cysteine alkylation in Actinobacteria
Abstract σR (SigR) is an alternative sigma factor that enables gene expression in Streptomyces coelicolor to cope wi...
EPEC‐induced activation of the Ca2+ transporter TRPV2 leads to pyroptotic cell death
EPEC‐induced activation of the Ca2+ transporter TRPV2 leads to pyroptotic cell death
Abstract The enteropathogenic Escherichia coli (EPEC) type III secretion system effector Tir, which mediates intimate bact...
Systematic evolution of initiation factor 3 and the ribosomal protein uS12 optimizes Escherichia coli growth with an unconventional initiator tRNA
Systematic evolution of initiation factor 3 and the ribosomal protein uS12 optimizes Escherichia coli growth with an unconventional initiator tRNA
ABSTRACT The anticodon stem of initiator tRNA (i-tRNA) possesses the characteristic three consecutive GC base pairs (G29:C...
Diverse molecular mechanisms of transcription regulation by the bacterial alarmone ppGpp
Diverse molecular mechanisms of transcription regulation by the bacterial alarmone ppGpp
Summary Bacteria must rapidly detect and respond to stressful environmental conditions. Guanosine tetraphosphate (ppGpp) i...
Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex
Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex
Abstract A definitive transcriptome atlas for the non-coding expressed elements of the members of the Mycobacterium tuberc...
Mycobacterium tuberculosis Endonuclease VIII 2 (Nei2) forms a prereplicative BER complex with DnaN: Identification, characterization, and disruption of complex formation
Mycobacterium tuberculosis Endonuclease VIII 2 (Nei2) forms a prereplicative BER complex with DnaN: Identification, characterization, and disruption of complex formation
Abstract Mycobacterium tuberculosis Nei2 (Rv3297) is a BER glycosylase that removes oxidized base lesions from ssDNA and r...
N‐acetylglucosamine transporter, Ngt1, undergoes sugar‐responsive endosomal trafficking in Candida albicans
N‐acetylglucosamine transporter, Ngt1, undergoes sugar‐responsive endosomal trafficking in Candida albicans
Abstract N-acetylglucosamine (GlcNAc), an important amino sugar at the infection sites of the fungal pathogen Candida albi...
The zinc finger protein StMR1 affects the pathogenicity and melanin synthesis of Setosphaeria turcica and directly regulates the expression of DHN melanin synthesis pathway genes
The zinc finger protein StMR1 affects the pathogenicity and melanin synthesis of Setosphaeria turcica and directly regulates the expression of DHN melanin synthesis pathway genes
Abstract The infection and colonization of pathogenic fungi are often regulated by transcription factors. In our previous ...
Proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila
Proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila
Abstract Legionella pneumophila is an opportunistic pathogen infecting alveolar macrophages and protozoa species. Legionel...
Perturbation of ATG16L1 function impairs the biogenesis of Salmonella and Coxiella replication vacuoles
Perturbation of ATG16L1 function impairs the biogenesis of Salmonella and Coxiella replication vacuoles
Summary Anti-bacterial autophagy, known as xenophagy, is a host innate immune response that targets invading pathogens for...
Identification of TbPBN1 in Trypanosoma brucei reveals a conserved heterodimeric architecture for glycosylphosphatidylinositol‐mannosyltransferase I
Identification of TbPBN1 in Trypanosoma brucei reveals a conserved heterodimeric architecture for glycosylphosphatidylinositol‐mannosyltransferase I
Abstract Glycosylphosphatidylinositol (GPI)-anchored proteins are found in all eukaryotes and are especially abundant on t...
Contribution of a ZIP‐family protein to manganese uptake and infective endocarditis virulence in Streptococcus sanguinis
Contribution of a ZIP‐family protein to manganese uptake and infective endocarditis virulence in Streptococcus sanguinis
Summary Streptococcus sanguinis is an important cause of infective endocarditis. In strain SK36, the ABC-family manganese ...
Evolutionary flexibility in routes to mat formation by Pseudomonas
Evolutionary flexibility in routes to mat formation by Pseudomonas
Abstract Many bacteria form mats at the air-liquid interface of static microcosms. These structures typically involve the ...
Manganese transport by Streptococcus sanguinis in acidic conditions and its impact on growth in vitro and in vivo
Manganese transport by Streptococcus sanguinis in acidic conditions and its impact on growth in vitro and in vivo
Summary Streptococcus sanguinis is an oral commensal and an etiological agent of infective endocarditis. Previous studies ...
Protein phosphatase SppA regulates apical growth and dephosphorylates cell polarity determinant DivIVA in Streptomyces coelicolor
Protein phosphatase SppA regulates apical growth and dephosphorylates cell polarity determinant DivIVA in Streptomyces coelicolor
Summary Members of the Actinobacteria, including mycobacteria and streptomycetes, exhibit a distinctive mode of polar grow...
Understanding parasite‐brain microvascular interactions with engineered 3D blood‐brain barrier models
Understanding parasite‐brain microvascular interactions with engineered 3D blood‐brain barrier models
Abstract Microbial interactions with the blood-brain barrier (BBB) can be highly pathogenic and are still not well underst...
Mycobacterium tuberculosis Endonuclease VIII 2 (Nei2) forms a pre‐replicative BER complex with DnaN: Identification, characterization, and disruption of complex formation
Mycobacterium tuberculosis Endonuclease VIII 2 (Nei2) forms a pre‐replicative BER complex with DnaN: Identification, characterization, and disruption of complex formation
ABSTRACT Mycobacterium tuberculosis Nei2 (Rv3297) is a BER glycosylase that removes oxidized base lesions from ssDNA and r...
The proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila
The proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila
Abstract Legionella pneumophila is an opportunistic pathogen infecting alveolar macrophages and protozoa species. Legionel...
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