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Clinicopathological analysis of BRAF and non-BRAF MAPK pathway-altered gliomas in paediatric and adult patients: a single-institution study of 40 patients
Clinicopathological analysis of BRAF and non-BRAF MAPK pathway-altered gliomas in paediatric and adult patients: a single-institution study of 40 patients
WHAT IS ALREADY KNOWN ON THIS TOPICMitogen-activated protein kinase (MAPK) signalling pathway is a major driver of gliomag...
Clinicopathological characterisation of MTAP alterations in gastrointestinal cancers
Clinicopathological characterisation of MTAP alterations in gastrointestinal cancers
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSGene loss is the most common MTAP alteration, almost exclusively oc...
Multisite clinical cross-validation and variant interpretation of a next generation sequencing panel for lymphoid cancer prognostication
Multisite clinical cross-validation and variant interpretation of a next generation sequencing panel for lymphoid cancer prognostication
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionLymphomas are chara...
Assessment of AI-based computational H&E staining versus chemical H&E staining for primary diagnosis in lymphomas: a brief interim report
Assessment of AI-based computational H&E staining versus chemical H&E staining for primary diagnosis in lymphomas: a brief interim report
Microscopic review of tissue sections is of foundational importance in pathology, yet the traditional chemistry-based hist...
Accuracy of GPT-4 in histopathological image detection and classification of colorectal adenomas
Accuracy of GPT-4 in histopathological image detection and classification of colorectal adenomas
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Peripheral blood smear and bone marrow findings in spontaneous tumour lysis syndrome associated with haematolymphoid malignancies
Peripheral blood smear and bone marrow findings in spontaneous tumour lysis syndrome associated with haematolymphoid malignancies
Spontaneous tumour lysis syndrome (STLS), occurring before any form of therapy, is a relatively rare phenomenon. Although ...
Ingested foreign bodies mimicking inflammatory bowel disease
Ingested foreign bodies mimicking inflammatory bowel disease
IntroductionInflammatory bowel disease (IBD) encompasses a group of idiopathic disorders, including Crohn’s disease and ul...
Unravelling the USP6 gene: an update
Unravelling the USP6 gene: an update
Ubiquitin-specific protease 6 (USP6) rearrangements have been identified in aneurysmal bone cyst, nodular fasciitis, myos...
Failure to thrive in a man in his late forties
Failure to thrive in a man in his late forties
Clinical presentationA man in his late 40s with a 30 pack-year cigarette smoking history and no other comorbidities presen...
Ketamine: friend or foe?
Ketamine: friend or foe?
Ketamine, a dissociative anaesthetic drug, acts on the central nervous system (CNS) primarily through antagonism of the n-...
Quantitative p53 immunostaining aids in the detection of prevalent dysplasia
Quantitative p53 immunostaining aids in the detection of prevalent dysplasia
IntroductionOesophageal adenocarcinoma (EAC) is an aggressive disease with a mean 5-year survival rate of only 15%.1 Most ...
Development of a LAG-3 immunohistochemistry assay for melanoma
Development of a LAG-3 immunohistochemistry assay for melanoma
IntroductionImmune checkpoint inhibitor–based therapies have greatly improved clinical outcomes across multiple disease se...
Postmortem survey of haemoglobin A1c, non-alcoholic steatohepatitis and liver fibrosis within a general population
Postmortem survey of haemoglobin A1c, non-alcoholic steatohepatitis and liver fibrosis within a general population
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MYCN amplification and International Neuroblastoma Risk Group stratification on fine-needle aspiration biopsy and their correlation to survival in neuroblastoma
MYCN amplification and International Neuroblastoma Risk Group stratification on fine-needle aspiration biopsy and their correlation to survival in neuroblastoma
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Implementation of the updated NICE haematological cancers (NG47) improving outcomes guidelines across Specialist Integrated Haematological Malignancy Diagnostic Services (SIHMDS) in England: a UK NEQAS LI survey
Implementation of the updated NICE haematological cancers (NG47) improving outcomes guidelines across Specialist Integrated Haematological Malignancy Diagnostic Services (SIHMDS) in England: a UK NEQAS LI survey
IntroductionThe National Institute for Health and Care Excellence (NICE) produces evidence-based guidance, based on clinic...
Improving care of melanoma patients through efficient, integrated cellular-molecular pathology workflows using tissue samples with low tumour nuclear content
Improving care of melanoma patients through efficient, integrated cellular-molecular pathology workflows using tissue samples with low tumour nuclear content
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One-step genotyping of {alpha}-thalassaemia by multiplex symmetric PCR melting curve
One-step genotyping of {alpha}-thalassaemia by multiplex symmetric PCR melting curve
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Beyond the routine CBC: machine learning and statistical analyses identify research CBC parameter associations with myelodysplastic syndromes and specific underlying pathogenic variants
Beyond the routine CBC: machine learning and statistical analyses identify research CBC parameter associations with myelodysplastic syndromes and specific underlying pathogenic variants
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Preparing for the next pandemic: lessons learnt from the implementation of point-of-care SARS-CoV-2 testing in an emergency department
Preparing for the next pandemic: lessons learnt from the implementation of point-of-care SARS-CoV-2 testing in an emergency department
IntroductionRapid laboratory diagnosis of SARS-CoV-2 is essential for hospital management of COVID-19. In addition to aidi...
Prevalence of elevated serum concentrations of biotin in patients from South East England, Korea, Singapore and Thailand and risk of immunoassay interference
Prevalence of elevated serum concentrations of biotin in patients from South East England, Korea, Singapore and Thailand and risk of immunoassay interference
Biotin interference in immunoassays using biotin-streptavidin binding technology is well recognised by clinical laboratori...
Assessing transfer of value from industry to physicians: the importance of studying and reporting the appropriate population
Assessing transfer of value from industry to physicians: the importance of studying and reporting the appropriate population
We read with interest a recent study analysing industry payments to pathologists in the USA.1 In this study, Murayama and ...
Drug-induced hyperammonaemia
Drug-induced hyperammonaemia
IntroductionHyperammonaemia (HA) (>40 µmol/L, 68 μg/L in adults, although method dependent) arises due to a number of c...
Factors predicting BRCA1/2 pathogenic variants in patients with ovarian cancer: a systematic review with meta-analysis
Factors predicting BRCA1/2 pathogenic variants in patients with ovarian cancer: a systematic review with meta-analysis
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Neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene or MYCN gene
Neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene or MYCN gene
The MYCN gene belongs to the MYC family of transcription factors. Amplification of MYCN, first discovered in neuroblastoma...
Dual resolution deep learning network with self-attention mechanism for classification and localisation of colorectal cancer in histopathological images
Dual resolution deep learning network with self-attention mechanism for classification and localisation of colorectal cancer in histopathological images
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Novel histological repertoire of crypt-associated anomalies in inflamed colon mucosa
Novel histological repertoire of crypt-associated anomalies in inflamed colon mucosa
IntroductionThe sagittal profile of the normal colon mucosa at low magnification discloses a wavy silhouette due to small ...
Overexpression of integrin alpha 2 (ITGA2) correlates with poor survival in patients with pancreatic ductal adenocarcinoma
Overexpression of integrin alpha 2 (ITGA2) correlates with poor survival in patients with pancreatic ductal adenocarcinoma
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Diagnostic utility of ERG immunostaining in dermatofibroma
Diagnostic utility of ERG immunostaining in dermatofibroma
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FOCUS4 biomarker laboratories: from the benefits to the practical and logistical issues faced during 6 years of centralised testing
FOCUS4 biomarker laboratories: from the benefits to the practical and logistical issues faced during 6 years of centralised testing
IntroductionWe are seeing an increase in clinical trials, requiring biomarker assessment to randomise patients to a partic...
Underdiagnosis of iron deficiency anaemia in HIV-infected individuals: a pilot study using soluble transferrin receptors and intensive bone marrow iron stores to improve the diagnosis
Underdiagnosis of iron deficiency anaemia in HIV-infected individuals: a pilot study using soluble transferrin receptors and intensive bone marrow iron stores to improve the diagnosis
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