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β-Catenin stabilization protects against alveolar hemorrhage through amphiregulin- and BATF-mediated Tregs
β-Catenin stabilization alters the CD8+ T cell phenotype. β-Catenin is required for both αβ and γδ T cell development (21...
Cardiac conduction system malformations in heterotaxy result from dysregulated Pitx2 expression
Disposition of CCS in Cryptic–/– embryos at E18.5. To investigate CCS disposition in mouse heterotaxy, we first examined ...
Targeting PI3Kγ anchoring enhances CFTR membrane localization and modulator efficacy via PKD1
Research ArticleCell biologyPulmonology Open Access | 10.1172/jci.insight.198846 Alessandra M...
Ex vivo–expanded allogeneic Vδ2 T cells specifically reduce reservoirs of HIV-1 following latency reversal
Sex as a biological variable. Self-reported biological sex of study participants was included as a variable for the analy...
Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium leading to nanophthalmos
Research ArticleGeneticsOphthalmology Open Access | 10.1172/jci.insight.194681 Gabrielle M. R...
CD9 regulates macrophage-mediated remodeling of adipose tissue in obesity
Research ArticleImmunologyMetabolism Open Access | 10.1172/jci.insight.193837 Julia Chini,1,2...
Reduced late endosome/lysosome function promotes SLE through chronic PI3K activity and SHP-1/SHIP-1 defects
Multiple hematopoietic cell types exhibit LEL dysfunction. Previous studies showed that bone marrow–derived Mφs (BMMφs) f...
Hypothyroidism impairs skeletal muscle regeneration after injury by altering myogenic and nonmyogenic pathways
Skeletal muscle regeneration after injury is impaired during hypothyroidism. To assess the impact of thyroid hormone defi...
Extracellular vesicle miR-93-5p cargo regulates glomerular endothelial cell damage in Alport syndrome
Research ArticleCell biologyNephrology Open Access | 10.1172/jci.insight.197643 Charmi Dedhia...
Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke
Research ArticleInflammationNephrology Open Access | 10.1172/jci.insight.189825 Min Zhang,1,2...
Endothelial oncogenic KRAS mutation drives the dynamics of microglia and macrophages in brain arteriovenous malformation
ECs carrying mutant KRAS lead to bAVM genesis. We previously showed that ECs carrying mutant human KRAS (KRAS-ECs) are su...
DAB2 in LGMD R2: a molecular link between disease progression and lipid dysregulation
Research ArticleCell biologyMuscle biology Open Access | 10.1172/jci.insight.200054 Celine Br...
DNA delivered by lipid nanoparticles induces CD8+ T cell–dependent antitumor responses and enhances anti–PD-L1 therapy
DNA delivered by LNPs induces an antitumor effect in mouse models of HCC. HCC is an optimal target for DNA-LNP therapy gi...
IFN-γ–induced trained immunity enhances killing of priority pathogens in healthy and genetically vulnerable individuals
Research ArticleImmunologyInfectious disease Open Access | 10.1172/jci.insight.195866 Dearbhl...
Consideration of spatial companion biomarkers for targeted therapeutics in cancer: depatuxizumab mafodotin in glioblastoma
Research LetterNeuroscienceOncology Open Access | 10.1172/jci.insight.198475 Rimas V. Lukas,1...
Heterozygous NFKB1 variant causes inflammatory dysregulation shaped by broader genetic context in common variable immunodeficiency
Research ArticleImmunologyInflammation Open Access | 10.1172/jci.insight.198703 Kevin M. Haye...
Epidermal NAD+ deficiency induces IL-36–mediated skin inflammation and acanthosis
Research ArticleDermatologyMetabolism Open Access | 10.1172/jci.insight.189177 Taiki Seki,1,2...
PI3K regulates TAZ/YAP and mTORC1 axes that can be synergistically targeted
PI3K is activated in sarcomas. To evaluate the mutational landscape of the PI3K signaling pathway, we analyzed publicly a...
Nrf2 activator peptide protects the brain from cerebral vascular dysfunction in alcohol ingestion
Determination of optimal dose and evaluation of drug safety. The peptide sequences used in this study, including the Nrf2...
Dietary palmitic acid inhibits colorectal cancer progression through enhancing bisecting GlcNAc
Bisecting GlcNAc levels are reduced in CRC tissues. We previously reported the downregulation of MGAT3 expression and bis...
Granzyme A as biomarker for diagnosis in tuberculous pleural effusion
Clinical MedicineInfectious disease Open Access | 10.1172/jci.insight.185307 Fuxiang Li,1,2 ...
Loss of O-GlcNAcylation modulates mTORC1 and autophagy in β cells, driving diabetes 2 progression
Dysregulation of OGT and mTORC1 in models of β cell dysfunction in mice and humans. β Cell mass and function are affected...
In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic efferent innervation in inner hair cells
Postnatal deletion of Myo7a leads to early-onset hearing loss. Targeted postnatal deletion of Myo7a was achieved by cross...
Brain region–specific neural activation by low-dose opioid promotes social behavior
Research ArticleNeuroscienceTherapeutics Open Access | 10.1172/jci.insight.182060 Soichiro Oh...
Comprehensive analysis of mesenchymal cells reveals a dysregulated TGF-β/WNT/HOXB7 axis in patients with myelofibrosis
Research ArticleHematology Open Access | 10.1172/jci.insight.173665 Saravanan Ganesan,1 S...
Aldosterone-induced salt appetite requires HSD2 neurons
Sex as a biological variable. Sex was not considered as a biological variable in these studies. Due to increased variabil...
Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolism
Research ArticleHepatologyMetabolism Open Access | 10.1172/jci.insight.184396 Se-Hyung Park,1...
Inhibiting triggering receptor expressed on myeloid cells 1 signaling to ameliorate skin fibrosis
Research ArticleInfectious disease Open Access | 10.1172/jci.insight.176319 Swarna Bale,1 ...
Rapid systemic spread and minimal immune responses following SIVsab intrarectal transmission in African green monkeys
Research ArticleAIDS/HIVVirology Open Access | 10.1172/jci.insight.183751 Kevin D. Raehtz,1 ...
Impact of genetic factors on antioxidant rescue of maternal diabetes–associated congenital heart disease
Research ArticleCardiologyDevelopment Open Access | 10.1172/jci.insight.183516 Talita Z. Chou...
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