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Status of advanced respiratory syncytial virus antiviral therapeutics 2025
Respiratory syncytial virus (RSV) is a negative-sense, single-stranded RNA virus of the pneumovirus family. Although reinf...
Human T-cell leukemia virus type I: modulation of viral gene expression and perturbation of host signaling pathways lead to persistent infection
Human T-cell leukemia virus type I (HTLV-1) was the first human pathogenic retrovirus to be discovered. HTLV-1 induces a T...
The Dengue NS1 epitope landscape: a blueprint for next-generation vaccines and therapeutics
The dengue virus (DENV) nonstructural protein 1 (NS1) is a critical ‘double-edged sword’ in dengue pathogenesis and immuni...
Host-targeted antivirals as broad-spectrum inhibitors of respiratory viruses
Respiratory viruses, including influenza virus, respiratory syncytial virus, human rhinovirus, and severe acute respirator...
New directions in the multifunctionality of RNA viruses: insights from the rabies virus P-protein
RNA viruses have compact genomes that typically encode only a few proteins, but these viruses orchestrate complex replicat...
Applications and limitations of respiratory virus infection models in well-differentiated airway epithelial cell cultures of livestock
Development of multispecies well-differentiated airway epithelial cell (WD-AEC) models derived from either primary cells o...
Intracranial calcifications in congenital viral infections: mechanisms and cellular roles
Intracranial calcifications (ICCs) are a characteristic neuropathological feature of several congenital viral infections, ...
Nexus of virus and brain: recent advances in flavivirus and enterovirus neuro-infection
Neurotropic RNA viruses pose a growing concern due to their ability to invade and damage the central nervous system (CNS),...
Intercellular highways of viral spread: tunneling nanotubes and extracellular vesicles at the maternal–fetal interface
The placenta is a fetal-derived organ that facilitates the exchange of nutrients, gases, and waste products between the mo...
Sequence variability of the K1 gene in Kaposi’s sarcoma-associated herpesvirus and its role in pathogenesis
Since its discovery in 1994, Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, has been i...
Virological and immunological determinants of hepatitis E virus infection outcomes
Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide, especially in regions with limited sanitati...
Severe fever with thrombocytopenia syndrome virus NSs: a multifaceted viral protein in host–virus interactions
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly lethal tick-borne bunyavirus, and its nonstructural ...
Multiple roles of the matrix protein Z in arenavirus infection — a structural perspective
For the conservation analysis exact sequences (accession numbers) and program details have been specified in the figure ca...
Evaluating the zoonotic spectrum of sandfly-borne phleboviruses, Africa
Sandfly-borne phleboviruses (SBPs) are an important cause of febrile diseases and neuroinvasive infections in humans, espe...
A novel antiviral strategy by disrupting the equilibrium of virus-host calcium homeostasis
Calcium (Ca2+) homeostasis is essential for cellular signaling and protein trafficking. Viruses are comparatively simple o...
A storm is born: immune activation and pathogenesis in arthritogenic alphavirus infections
Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, and Mayaro viruses, are emerging global viruses res...
Epstein–Barr virus lytic replication and cancer
Epidemiological studies have provided strong evidence that Epstein–Barr virus (EBV) lytic replication is linked to cancer ...
Transmission patterns of hepatitis E virus
Hepatitis E virus (HEV) causes sporadic cases in industrialized countries and endemic outbreaks in areas with lower sanita...
In vitro modeling of influenza infection in the respiratory epithelium: advanced cellular models to better understand complex host–virus interactions
Influenza viruses pose significant global health threats, causing widespread morbidity and mortality due to their genetic ...
Human brain tissue cultures: a unique ex vivo model to unravel the pathogenesis of neurotropic arboviruses
Arboviruses are viruses transmitted through the bite of blood-feeding arthropods, such as mosquitoes, ticks, sandflies, an...
Human placental models for studying viral infections
Viral infections during pregnancy represent a major threat to maternal, fetal, and neonatal health outcome, with a high ri...
Recent advances in animal models of lymphomagenesis caused by human γ-herpesviruses
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
The natural virome and pandemic potential: Disease X
The natural virome and pandemic potential: Disease X
Over the last decade, the emergence of several zoonotic viruses has demonstrated that previously unknown or neglected path...
Pathogenesis of severe acute respiratory syndrome coronavirus-2 in nonhuman primates
Pathogenesis of severe acute respiratory syndrome coronavirus-2 in nonhuman primates
The continued pressure of COVID-19 on public health worldwide underlines the need for a better understanding of the mechan...
Editorial overview: The virome in health and disease (2022)
Editorial overview: The virome in health and disease (2022)
Jelle Matthijnssens Prof. Jelle Matthijnssens was appointed as assistant professor at the Rega Institute at KU Leuven, Bel...
Transmission of severe acute respiratory syndrome coronavirus 2 from humans to animals: is there a risk of novel reservoirs?
Transmission of severe acute respiratory syndrome coronavirus 2 from humans to animals: is there a risk of novel reservoirs?
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a zoonotic virus able to infect humans and multiple nonhum...
Hepatitis-B virus: replication cycle, targets, and antiviral approaches
Hepatitis-B virus: replication cycle, targets, and antiviral approaches
Available online 10 September 2023, 101360Author links open overlay panel, , , Highlights•Hepatitis B is a major cause of ...
Genetic and pharmacological perturbation of hepatitis-C virus entry
Genetic and pharmacological perturbation of hepatitis-C virus entry
Hepatitis-C virus (HCV) chronically infects 58 million individuals worldwide with variable disease outcome. While a subfra...
Role of the viral polymerase during adaptation of influenza A viruses to new hosts
Role of the viral polymerase during adaptation of influenza A viruses to new hosts
As a group, influenza-A viruses (IAV) infect a wide range of animal hosts, however, they are constrained to infecting sele...
Editorial overview: Viruses and Cancer
Editorial overview: Viruses and Cancer
Volume 62, October 2023, 101364Author links open overlay panelEthel Cesarman, Jennifer TotonchyShow morePrevious article i...
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