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Evaluation of a diagnostic metagenomic sequencing assay: Virus detection sensitivity and background nucleic acids in three different sample materials
BackgroundMetagenomic sequencing has emerged as an attractive, general, and agnostic diagnostic method, in particular for ...
Performance of the Alinity m HR HPV assay on self-collected vaginal samples compared to clinician-collected cervical samples
Nicolas Wentzensen: Writing – review & editing, Supervision, Resources, Project administration, Methodology, Investiga...
Detection and molecular characterisation of tick-borne encephalitis virus in CSF and serum in relation to disease severity
ObjectivesWe aimed to 1) detect tick-borne encephalitis virus (TBEV) RNA in clinical samples from patients with TBE, 2) ch...
A laboratory-developed test for the automated molecular detection of mpox clade I, mpox clade II, and non-variola Orthopoxvirus using the Panther Fusion® System
Monkeypox virus (MPXV), a zoonotic virus in the genus Orthopoxvirus, is an emerging pathogen endemic within Central and We...
Evaluation of cytomegalovirus cell-mediated immunity assays in the healthy Singapore cohort and challenges of test validation
Soon Hwee Ng: Writing – review & editing, Writing – original draft, Visualization, Validation, Supervision, Project ad...
Serological analysis of COVID-19 patients highlights cross-reactivity of antibodies with the HIV-1 2F5 epitope
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to a global public heal...
Anti-cluster A and anti-p24 antibodies in people with multidrug-resistant HIV: Preliminary observations from the PRESTIGIO registry
IntroductionData on soluble gp120 (sgp120) and anti-HIV antibodies are lacking in people with HIV (PWH) and multidrug resi...
The prognostic potential of fetal platelet count and viral load in prenatal cytomegalovirus infection: a retrospective cohort of 74 cases
Megane Bellemans: Data curation. Elena Costa: Validation, Supervision, Software, Methodology, Formal analysis. Marie-Luce ...
The diagnostic complexities of human herpesvirus 6 (HHV-6) infections
Volume 182, February 2026, 105905Author links open overlay panel, , , AbstractHuman herpesvirus 6 (HHV-6) is a common viru...
Development and evaluation of a novel RT-qPCR assay for detection of Crimean Congo haemorrhagic fever virus using the Genedrive® point-of-care platform
Volume 182, February 2026, 105889Author links open overlay panel, , , , , , , , , , , , , , , , , Highlights•Design and ev...
High levels of transmitted drug resistance to INSTIs and NNRTIs in Chile: A nationwide prevalence study
Antiretroviral therapy (ART) has successfully reduced human immunodeficiency virus (HIV) morbi-mortality worldwide, and tr...
Bacterial colonization and life-threatening respiratory syncytial virus infection in children
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (ALRI) and bronchiolitis ...
Head-to-head comparison of the performance of BIOFIRE® SPOTFIRE® Respiratory/Sore Throat Panel, Cepheid Xpert® Xpress SARS-CoV-2/Flu/RSV and Cobas® SARS-CoV-2 & Influenza A/B assay for detection of respiratory viruses
Viruses such as influenza virus (Flu), respiratory syncytial virus (RSV), and SARS-CoV-2 are the major cause of acute resp...
Optimized respiratory virus influenza A whole genome sequencing strategies for improving even read coverage of segments
Influenza viruses are divided into four distinct types, A, B, C, and D. While influenza A and influenza B are primarily re...
External quality assessment for molecular detection of multiple respiratory pathogens in China
Acute respiratory infections (ARIs) remain a leading cause of clinic visits and the fourth most common cause of mortality ...
Clinical evaluation of nasal swab specimens in VTM/UTM and RespDirect eSTM using the Panther Fusion SARS-CoV-2/Flu A/B/RSV assay
Volume 182, February 2026, 105908Author links open overlay panel, , , , , , , , Highlights•Nasal swabs are less invasive a...
Peptide-assisted direct detection of HPV nucleic acids from liquid-based cytology samples without extraction
High-risk human papillomavirus (hrHPV) is the primary cause of nearly all cervical cancers and contributes to a subset of ...
Fourth generation HIV rapid diagnostic test: Adequate sensitivity in HIV primary infection settings?
BackgroundHIV rapid diagnostic tests (RDT) enable easy point-of-care screenings but traditionally lack the HIV-1 p24-antig...
Is there a need to repeat single assay reactive HIV screens? A review of practice in two UK sites
Volume 182, February 2026, 105906Author links open overlay panel, , , , , , , , Highlights•The interpretation of discordan...
Detection of diverse HIV strains by the m-PIMATM HIV-1/2 detect point-of-care assay
BackgroundHIV displays exceptionally high virus diversity that can impact detection by diagnostic assays, which rely on se...
Evaluation of the analytical performances of the Alinity-i HSV-1 IgG and HSV-2 IgG chemiluminescent immunoassays
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) represent a significant global health burden, with an estimated serop...
Development and evaluation of the digital PCR-based method for clinical monitoring of viral loads during severe fever with thrombocytopenia syndrome virus infection
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a novel bunyavirus that has emerged as a significant public h...
Comparison of patients presenting to emergency departments infected with respiratory syncytial virus versus influenza virus: A retrospective cohort study
Volume 177, April 2025, 105775Author links open overlay panel, , , , , , , , , , , , , , Highlights•Largest study on RSV v...
Three-year hearing outcomes in infants with congenital cytomegalovirus disease treated with oral valganciclovir: Interim results of a six-year follow-up study in Japan
Congenital hearing loss is estimated to occur in 1–1.5 per 1000 individuals, with congenital cytomegalovirus (CMV) infecti...
Human papillomavirus incidence and transmission by vaccination status among heterosexual couples
Volume 177, April 2025, 105779Author links open overlay panel, , , , , Highlights●Weak protection in males was observed fr...
Nucleocapsid-directed antibody testing is unsuitable to estimate hybrid immunity against SARS-CoV-2, a longitudinal cross-border study in the Meuse-Rhine Euroregion
Volume 177, April 2025, 105780Author links open overlay panel, , , , , , , , , , , , Highlights●Differences in COVID-19 in...
Molecular epidemiology of Kyasanur forest disease employing ONT-NGS a field forward sequencing
To identify infectious agents in the future, it is essential to focus on surveillance and outbreak responses through field...
Feasibility and performance evaluations of Alinity m quantitative NAT for HBV and HCV
BackgroundRapid and accurate testing for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) is essential for management o...
High rate of RNAemia and impaired immunity in patients with immunodeficiency in the vaccination era
Volume 177, April 2025, 105774Author links open overlay panel, , , , , , , , , , Highlights•SARS-CoV-2 RNAemia is common i...
Impact of metformin on HBV replication: No evidence of suppression in vitro
Volume 177, April 2025, 105781Author links open overlay panel, , , Highlights●We used HepAD38 cells to investigate the mec...
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