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PZP deficiency impairs M2 macrophage polarization via TGF-β/Smad3 signaling, contributing to immune dysregulation at the maternal-fetal interface in preeclampsia

Anti-inflammatory and barrier-protective effects of Lactiplantibacillus plantarum WB4303 and WB4304 via modulation of NF-κB and MAPK signaling in LPS-stimulated HT-29 cells

Molecular Immunology

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The role of apolipoprotein C1 in mediating pyroptosis in Hashimoto’s thyroiditis via TLR10/MyD88/NF-κB pathway

Molecular Immunology

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Immunorestorative effects of caraway and marjoram extracts on Th2-mediated inflammation in house dust mite–triggered asthma

Molecular Immunology

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Wnt7a mediates the Wnt/β-catenin signaling pathway to influence ferroptosis in T lymphocytes of HIV-infected individuals

Molecular Immunology

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Puerarin and DHEA combination therapy alleviates primary dysmenorrhea via inhibition of the Hsp90ab1/p38/JNK pathway

Molecular Immunology

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NAT10 promotes lung cancer progression by enhancing glutamine metabolism through increasing ac4C modification on NIT2

Molecular Immunology

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Siglec-15 promotes M2 polarization of Kupffer cells via DAP12/IRAK-M axis to alleviate acute rejection in liver transplantation

Molecular Immunology

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Glutathione depletion activates cGAS-STING signaling via oxidative stress in preeclampsia

Molecular Immunology

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Sinigrin inhibits PD-L1 expression via suppressing the JAK-STAT signaling pathway to modulate the tumor immune microenvironment in lung cancer

Molecular Immunology

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Neutrophil extracellular traps-related biomarkers in idiopathic pulmonary arterial hypertension: A machine learning-based identification and experimental validation study

Molecular Immunology

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Quercetin attenuates LTA-induced tight junction disruption in mammary epithelial cells by modulating autophagy via the AMPK/mTOR pathway

Molecular Immunology

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Promoting keratinocyte psoriasiform changes and IL-17RE expression: Potential role of GLT1D1 in linear psoriasis

Molecular Immunology

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PIAS1 attenuates the progression of abdominal aortic aneurysm by stabilizing PPARγ through SUMOylation

Molecular Immunology

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Edwardsiella piscicida effector VgrG contributes to NCOA4-dependent ferritinophagy as a bacterial survival strategy in fish

Molecular Immunology

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The CLEC-2–podoplanin axis inhibits dendritic cells migration and prolongs allograft survival in mice

Molecular Immunology

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CSF1R signaling contributes to macrophage-associated CCL11 production and eosinophil recruitment in murine allergic conjunctivitis

Molecular Immunology

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Acupuncture enhances warm kidney and spleen granules efficacy in diabetic diarrhea through synergistic p300/CBP inhibition and Nrf2/HO-1 pathway activation

Molecular Immunology

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ALKBH5-mediated m6A demethylation modification of RAD51 inhibits osteogenic differentiation via promoting DNA damage in osteoporosis

Osteoporosis (OP), characterized by reduced bone mineral density and degraded bone microarchitecture, significantly increa...

Molecular Immunology

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Sigmoidin B attenuates sepsis-associated encephalopathy through EZH2-AKT2-mediated regulation of microglial polarization

Sepsis, a syndromic response to infection, contributes to nearly 20 % of all deaths in 2017 and imposes significant burden...

Molecular Immunology

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Formononetin ameliorates allergic asthma by inhibiting JUN and suppressing type Ⅱ immune responses mediated by ILC2 cells

Allergic asthma (AS) is a chronic respiratory disorder, approximately 357.4 million people worldwide are afflicted with AS...

Molecular Immunology

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DAP12 affects the acute inflammatory response caused by UPEC or LPS by regulating macrophage infiltration

Urinary tract infection (UTI) is a prevalent bacterial infection, predominantly caused by uropathogenic Escherichia coli (...

Molecular Immunology

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NRF1 alleviates cerebral ischemia-reperfusion injury by transcriptionally activating FTO and downregulating m6A-mediated FOXO1 expression

Stroke is one of the most common causes of serious long-term disability and death in patients worldwide. It’s caused by an...

Molecular Immunology

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Exosomal miR-214–3p reprograms BMSC fate: A novel intercellular mechanism linking vascular insufficiency to impaired bone regeneration in nontraumatic ONFH

Non-traumatic osteonecrosis of the femoral head (NONFH) is a prevalent and challenging orthopedic condition that primarily...

Molecular Immunology

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The protective role of Astragaloside IV in adriamycin-induced renal injury: A focus on macrophage polarization and PPARγ activation

Currently, the pathogenesis of nephrotic syndrome remains uncertain, but examination of affected kidney tissue reveals pro...

Molecular Immunology

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The circERBB3/chi-miR-181b-5p/TNFSF11 axis regulates proliferation, migration, and apoptosis in cashmere goat embryonic fibroblasts

Hair is the dominant feature of mammals and has a wide range of functions, including thermoregulation, body protection, se...

Molecular Immunology

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An indirect ELISA for the detection of anti-NY-ESO-1 antibodies in cancer patients and for monitoring cancer therapy

Early diagnosis of cancer offers the best chance for effective treatment. Serological tests for the detection of cancer te...

Molecular Immunology

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Curcumin modulates tracheal epithelial cell autophagy in asthma by inhibiting the NF-κB pathway via SCGB3A2

Background and objectiveAsthma, a chronic inflammatory airway disease, presents a significant global health burden. This s...

Molecular Immunology

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