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Assessing the consistency of mass spectrometry, a clinical-laboratory model, and immunohistochemistry in amyloid subtyping: a Brazilian experience
Assessing the consistency of mass spectrometry, a clinical-laboratory model, and immunohistochemistry in amyloid subtyping: a Brazilian experience
Systemic amyloidosis is a potentially fatal protein misfolding disorder usually underdiagnosed in low- and middle-income c...
Causal effects and mediation pathways of circulating plasma proteins on osteoporosis: a two-sample and two-step Mendelian randomization study
Causal effects and mediation pathways of circulating plasma proteins on osteoporosis: a two-sample and two-step Mendelian randomization study
This study, using a two-sample and two-step Mendelian randomization (MR) approach, reveals a causal relationship between s...
Novel proteomic characterization of multiple myeloma bone marrow interstitial fluid links prognosis to coagulation pathways
Novel proteomic characterization of multiple myeloma bone marrow interstitial fluid links prognosis to coagulation pathways
Multiple myeloma (MM), the second most prevalent hematological malignancy, carries high morbidity with variability in clin...
Identification of adrenocorticotropic hormone–specific therapeutic biomarkers in infantile epileptic spasm syndrome using data-independent acquisition mass spectrometry
Identification of adrenocorticotropic hormone–specific therapeutic biomarkers in infantile epileptic spasm syndrome using data-independent acquisition mass spectrometry
Infantile epileptic spasm syndrome (IESS) presents significant therapeutic challenges, with the molecular mechanisms under...
Comprehensive proteome profiling of cytochrome P450 isoforms in cancer models
Comprehensive proteome profiling of cytochrome P450 isoforms in cancer models
Cytochrome P450 (CYP450) enzymes are essential for drug metabolism, xenobiotic detoxification, and procarcinogen activatio...
The effect of storage time and temperature on the proteomic analysis of FFPE tissue sections
The effect of storage time and temperature on the proteomic analysis of FFPE tissue sections
Formalin-fixed paraffin-embedded (FFPE) tissues present an important resource for cancer proteomics. They are more readily...
Integrated proteomics and N-glycoproteomic characterization of glioblastoma multiform revealed N-glycosylation heterogeneities as well as alterations in sialyation and fucosylation
Integrated proteomics and N-glycoproteomic characterization of glioblastoma multiform revealed N-glycosylation heterogeneities as well as alterations in sialyation and fucosylation
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor. Notwithstanding tremendous efforts having ...
Identification of novel proteomic biomarkers for hypertension: a targeted approach for precision medicine
Identification of novel proteomic biomarkers for hypertension: a targeted approach for precision medicine
Hypertension is a critical public health issue worldwide. The identification of specific proteomic biomarkers in the Qatar...
Admission glucose, HbA1c levels and inflammatory cytokines in patients with acute ST-elevation myocardial infarction
Admission glucose, HbA1c levels and inflammatory cytokines in patients with acute ST-elevation myocardial infarction
To investigate the association between admission glucose and HbA1c values and inflammatory plasma proteins in hospitalized...
Spatial top-down proteomics for the functional characterization of human kidney
Spatial top-down proteomics for the functional characterization of human kidney
The Human Proteome Project has credibly detected nearly 93% of the roughly 20,000 proteins which are predicted by the huma...
sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides
sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides
Cell surface proteins perform critical functions related to immune response, signal transduction, cell–cell interact...
Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue
Quantitative proteomics analysis based on data-independent acquisition reveals the effect of Shenling Baizhu powder (SLP) on protein expression in MAFLD rat liver tissue
Metabolic associated fatty liver disease (MAFLD) has become the most common chronic liver disease worldwide, and it is als...
Proteomic analysis of chromophobe renal cell carcinoma and benign renal oncocytoma biopsies reveals shared metabolic dysregulation
Proteomic analysis of chromophobe renal cell carcinoma and benign renal oncocytoma biopsies reveals shared metabolic dysregulation
This study investigates the proteomic landscapes of chromophobe renal cell carcinoma (chRCC) and renal oncocytomas (RO), t...
Validation of the novel GLAS algorithm as an aid in the detection of liver fibrosis and cirrhosis based on GP73, LG2m, age, and sex
Validation of the novel GLAS algorithm as an aid in the detection of liver fibrosis and cirrhosis based on GP73, LG2m, age, and sex
Diagnosis of liver disease at earlier stages can improve outcomes and reduce the risk of progression to malignancy. Liver ...
Development of a predictive model to distinguish prostate cancer from benign prostatic hyperplasia by integrating serum glycoproteomics and clinical variables
Development of a predictive model to distinguish prostate cancer from benign prostatic hyperplasia by integrating serum glycoproteomics and clinical variables
Prostate Cancer (PCa) represents the second leading cause of cancer-related death in men. Prostate-specific antigen (PSA) ...
Comparison of in-gel and in-solution proteolysis in the proteome profiling of organ perfusion solutions
Comparison of in-gel and in-solution proteolysis in the proteome profiling of organ perfusion solutions
The organ perfusion solution (perfusate), collected at clinically and temporally significant stages of the organ preservat...
Candidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics
Candidate biomarkers for treatment benefit from sunitinib in patients with advanced renal cell carcinoma using mass spectrometry-based (phospho)proteomics
The tyrosine kinase inhibitor sunitinib is an effective first-line treatment for patients with advanced renal cell carcino...
A pathway activity-based proteomic classifier stratifies prostate tumors into two subtypes
A pathway activity-based proteomic classifier stratifies prostate tumors into two subtypes
Prostate cancer (PCa) is the second most common cancer in males worldwide. The risk stratification of PCa is mainly based ...
Change of histone H3 lysine 14 acetylation stoichiometry in human monocyte derived macrophages as determined by MS-based absolute targeted quantitative proteomic approach: HIV infection and methamphetamine exposure
Change of histone H3 lysine 14 acetylation stoichiometry in human monocyte derived macrophages as determined by MS-based absolute targeted quantitative proteomic approach: HIV infection and methamphetamine exposure
Histones posttranslational modification represent an epigenetic mechanism that regulate gene expression and other cellular...
Comment on “Cerebrospinal fluid camk2a levels at baseline predict long-term progression in multiple sclerosis. Clinical Proteomics”
Comment on “Cerebrospinal fluid camk2a levels at baseline predict long-term progression in multiple sclerosis. Clinical Proteomics”
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue
Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue
Quantification of drug-target binding is critical for confirming that drugs reach their intended protein targets, understa...
Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers
Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers
Glioblastoma is one of the most malignant primary brain cancer. Despite surgical resection with modern technology followed...
Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque québécoise de la COVID-19 (BQC-19)
Validation of ANG-1 and P-SEL as biomarkers of post-COVID-19 conditions using data from the Biobanque québécoise de la COVID-19 (BQC-19)
The quest for understanding and managing the long-term effects of COVID-19, often referred to as Long COVID or post-COVID-...
Proteomic analyses reveal cystatin c is a promising biomarker for evaluation of systemic lupus erythematosus
Proteomic analyses reveal cystatin c is a promising biomarker for evaluation of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease with multiple organ involvement, especially the kidneys. Howev...
Redefining serological diagnostics with immunoaffinity proteomics
Redefining serological diagnostics with immunoaffinity proteomics
Serological diagnostics is generally defined as the detection of specific human immunoglobulins developed against viral, b...
A large-scale targeted proteomics of serum and tissue shows the utility of classifying high grade and low grade meningioma tumors
A large-scale targeted proteomics of serum and tissue shows the utility of classifying high grade and low grade meningioma tumors
Meningiomas are the most prevalent primary brain tumors. Due to their increasing burden on healthcare, meningiomas have be...
Development of an ID-LC–MS/MS method using targeted proteomics for quantifying cardiac troponin I in human serum
Development of an ID-LC–MS/MS method using targeted proteomics for quantifying cardiac troponin I in human serum
Cardiac troponin is a complex protein consisting of the three subunits I, T and C located in heart muscle cells. When the ...
Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization
Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors. New drug targets and proteins that would assi...
Proteome analysis of CD5-positive diffuse large B cell lymphoma FFPE tissue reveals downregulation of DDX3X, DNAJB1, and B cell receptor signaling pathway proteins including BTK and Immunoglobulins
Proteome analysis of CD5-positive diffuse large B cell lymphoma FFPE tissue reveals downregulation of DDX3X, DNAJB1, and B cell receptor signaling pathway proteins including BTK and Immunoglobulins
The molecular pathology of diffuse large B cell lymphoma (DLBCL) has been extensively studied. Among DLBCL subtypes, the p...
Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy
Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy
Differentiating between a normal intrauterine pregnancy (IUP) and abnormal conditions including early pregnancy loss (EPL)...
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