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MFN2 interacts with phosphorylated AMPK to mediate mitophagy in MCF-7 cells
Mitophagy selectively eliminates damaged mitochondria through distinct molecular pathways (C. Chen et al., 2024). The PINK...
Xiaoyou decoction suppresses cervical precancerous lesions through the activation of cellular autophagy and the upregulation of p53 expression
Cervical cancer (CC) is one of the most common malignant tumors of the female reproductive tract, with persistently high g...
Fetal muscle stem cell-derived exosomes improve dexamethasone-induced muscle atrophy at the single muscle fiber level
Skeletal muscle, the largest organ in the human body, is primarily responsible for locomotion through the contraction and ...
Comparison of disruption methods to optimize the evaluation of mitochondrial enzymatic activities in human fibroblasts
Cell lysis is a crucial step to conduct functional mitochondrial assays, where the primary objective is to provide access ...
CircTHBS1 aggravates peritoneal fibrosis by sponging miR-18a-5p and interacting with CTGF
End-stage renal disease (ESRD) can be effectively treated with peritoneal dialysis (PD), and over 272,000 ESRD patients wo...
Maternal High-Fat Diet-Induced Obesity in Offspring: Unraveling Adipose Tissue Dysfunction Mediated by Increased Heat Shock Proteins
Maternal weight and diet before and during pregnancy have a substantial impact on offspring metabolic health, though sex-s...
CAPRIN1/TYMS/MTHFD2 axis promotes EMT process in nasopharyngeal carcinoma development
Nasopharyngeal carcinoma (NPC), a type of head and neck squamous cell carcinoma (HNSCC), is a malignant tumor that origina...
Inhibition of M2 macrophage-mediated mesenchymal stem cell migration: Boldine attenuates elbow heterotopic ossification
Heterotopic ossification (HO) is a pathological process characterized by the abnormal formation of bone in soft tissues, s...
Single-cell transcriptomics and metabolomics reveal the potential role of ASRGL1 in metabolic reprogramming and invasion of nasopharyngeal carcinoma cells
Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial tissue of the nasopharynx. It is highl...
Restoration of A2M reduces drug resistance and malignancy in paclitaxel-resistant lung cancer cells
Lung cancer is one of the most prevalent malignant neoplasms and represents the leading cause of cancer-related mortality ...
Morin inhibits the progression of 5-fluorouracil–resistant colorectal cancer by suppressing autophagy
Colorectal cancer (CRC) is one of the most prevalent and deadly cancers of the digestive system, ranking third globally in...
Acalabrutinib alleviates metabolic dysfunction–associated steatotic liver disease by regulating bile acid metabolism
Metabolic dysfunction–associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (N...
Mycobacterium tuberculosis curli pili reduces oxygen consumption rate of THP-1 macrophages during early infection
All data generated or analysed for this manuscript are included in this publication and supplementary files. Additional da...
Silencing HMGB1 secretion inhibited EV71-induced blood-brain barrier dysfunction and neural inflammation by depressing astrocyte activation via sHh signal blockage
Hand-foot-mouth disease (HFMD) is a common acute febrile and eruptive infectious disease caused by enterovirus and more co...
Deciphering the molecular heterogeneity of soft tissue sarcoma by integrating multiomics and single cell sequence
Soft tissue sarcomas (STS) are a heterogeneous group of malignancies arising from mesenchymal tissues, including muscle, f...
ARHGAP11A is a potential prognostic biomarker and therapeutic target for pancreatic adenocarcinoma
Pancreatic adenocarcinoma (PAAD), accounting for 85 % of pancreatic cancer, is one of the most malignant and prevalent tum...
p38 MAPK–mediated upregulation of claudin-3 and claudin-4 by gemcitabine contributes to chemoresistance in ovarian cancer
Claudins (CLDNs) are tetraspan transmembrane proteins playing important function for tight junction formation and cell pol...
Clostridium butyricum protects the ileal barrier in mice by regulating the farnesoid X receptor signaling pathway
The human gut has digestion, absorption, barrier, and immune functions. The intestinal barrier mainly keeps the body away ...
Critical role of argininosuccinate lyase in TAp73-mediated proliferating tumor cells
The proliferation of tumor cells is a central feature of tumor development, requiring a significant supply of nutrients pr...
Serine phosphorylation of protein arginine methyltransferase Hmt1 is critical for controlling its protein levels
Protein arginine methylation has emerged as a key regulator in protein function in eukaryotes. This modification alters th...
Medium-dose irradiation impairs long-term hematopoietic stem cell functionality and hematopoietic resilience to cytotoxic stress
Irradiation and 5-fluorouracil (5-FU) are widely utilized tools in hematopoietic research to generate myeloablation and as...
Bifidobacterium apoptosis induction by measuring bax and caspases on SW948 human colon cancer cell line
The human intestinal flora is home to a diverse range of bacteria, many of which are vital for optimizing digestion. Among...
Cannabigerol – A potent regulator of insulin sensitivity in rat’s skeletal muscle via targeting the sphingolipid metabolism and PI3K/Akt/mTOR pathway?
Despite the great advances in medicine, there is a compelling need to develop alternative strategies to effectively treat ...
Cofilin is a key regulator of oxidative stress-induced intercellular tunneling nanotubes formation
Tunneling nanotubes (TNTs) are open-ended channels that facilitate membrane continuity between connected cells. They were ...
PYCR2, induced by c-Myc, promotes the invasiveness and metastasis of breast cancer by activating AKT signalling pathway
PYCR2, induced by c-Myc, promotes the invasiveness and metastasis of breast cancer by activating AKT signalling pathway
BackgroundPyrroline-5-carboxylate reductase 2 (PYCR2) expression is aberrantly upregulated in colon cancer. However, the f...
Corrigendum to “GOLGI: cancer cell fate control” [Int. J. Biochem. Cell Biol. 145 (2022) 106174]
Corrigendum to “GOLGI: cancer cell fate control” [Int. J. Biochem. Cell Biol. 145 (2022) 106174]
Volume 166, January 2024, 106504Author links open overlay panelMarta Martins, Ana Sofia Fernandes, Nuno SaraivaShow morePr...
Hedgehog signalling in CD4+ T helper cell polarisation
Hedgehog signalling in CD4+ T helper cell polarisation
CD4+ T cells are part of the adaptive immune system and can polarise into different T helper (Th) cell subsets to orchestr...
BNIP3 in hypoxia-induced mitophagy: novel insights and promising target for non-alcoholic fatty liver disease
BNIP3 in hypoxia-induced mitophagy: novel insights and promising target for non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) remains the most threatening liver disease worldwide. The incidence rate is incr...
THE ROLE OF α7 NICOTINIC ACETYLCHOLINE RECEPTORS IN POST-ACUTE SEQUELAE OF COVID-19
THE ROLE OF α7 NICOTINIC ACETYLCHOLINE RECEPTORS IN POST-ACUTE SEQUELAE OF COVID-19
SARS-Cov-2 infections have claimed nearly 7 million lives worldwide since 2019. While quarantines, non-pharmaceutical mand...
Molecular and cellular evidence of a direct interaction between the TRAF2 C-terminal domain and ganglioside GM1
Molecular and cellular evidence of a direct interaction between the TRAF2 C-terminal domain and ganglioside GM1
AbbreviationsTRAF2TNF receptor-associated factor 2GM1monosialotetrahexosylgangliosideGUVsgiant unilamellar vesiclesPOPC1-p...
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