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The role of ANGPTL8 in metabolism and cardiovascular diseases: Consensus and controversy
Cardiovascular disease (CVD) is one of the leading causes of death and disease burden worldwide. With ongoing shifts in li...
Remnant cholesterol and particle number of VLDL subfractions in coronary artery disease: Pros and cons
Emerging evidence from large observational studies and causal genetic studies suggest that elevated very-low-density lipop...
OGT deficiency in vascular smooth muscle orchestrates foam cell formation and PANoptosis during atherosclerotic progression
Atherosclerosis is a chronic cardiovascular disease characterized by the accumulation of fibrous plaques in arterial walls...
Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis
Background and aimsEpitranscriptomic RNA modifications play a crucial role in RNA processing, stability, and function. Sma...
C-reactive protein exacerbates high-fat diet-induced atherosclerosis via a liver-to-vessel axis that determines therapeutic efficacy of atorvastatin
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality worldwide. The initiation a...
Heparin decreases serum sphingosine-1-phosphate levels in patients with vascular diseases
Volume 412, January 2026, 120593Author links open overlay panel, , , , , , , , , , , Highlights•Determinants of circulatin...
Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants
Volume 412, January 2026, 120603Author links open overlay panelRaymond Noordam a b ⁎ 1, Wenyi Wang c 1, Pavithra Nagarajan...
Physical activity in carotid atherosclerotic patients blunts monocyte pro-inflammatory processes: a randomised controlled trial
Volume 412, January 2026, 120589Author links open overlay panelMathilde Mura a b, Amandine Thomas a, Michèle Weiss-Gayet c...
Imputation of untreated LDL-C in treated subjects with homozygous familial hypercholesterolaemia: An international collaboration
Background and aimsDiagnosis of Homozygous Familial Hypercholesterolaemia (HoFH) relies on untreated low-density lipoprote...
Associations of long-term cumulative C-reactive protein and glycoprotein acetyls concentrations in childhood, adolescence and adulthood with adulthood retinal microvascular structure
Volume 412, January 2026, 120595Author links open overlay panel, , , , , , , , , , , , , , , , , Highlights•Long-term cumu...
Association between the single-point insulin sensitivity estimator and cardiovascular disease incidence: A prospective nationwide cohort study involving two cohorts
MethodsThe study included 5755 participants from the Chinese Longitudinal Healthy Longevity Survey (CHARLS) and 2598 from ...
Effect of alirocumab on coronary plaque stratified by atherothrombotic risk
Volume 412, January 2026, 120588Author links open overlay panel, , , , , , , , , , , , , , , Highlights•Around 40% of AMI ...
AI-ECG age predicts carotid atherosclerotic plaque volume and progression
Volume 412, January 2026, 120592Author links open overlay panel, , , , , , , , Highlights•AI ECG age independently associa...
Association between C-reactive protein and adverse events in secondary cardiovascular prevention: A systematic review and meta-analysis of prognostic factor studies
Background and aimsC-reactive protein (CRP) has been associated with an increased risk of cardiovascular events in the set...
Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation
Volume 413, February 2026, 120608Author links open overlay panel, , , , , , , , , , , , , , , , , , , …Highlights•Gal-1 tr...
Lipid changes in females with familial hypercholesterolemia during the menopausal transition period
Familial Hypercholesterolemia (FH) is one of the most common forms of inherited dyslipidemia, with a prevalence of 1 in 31...
Identifying plasma proteomic biomarkers for risk prediction and therapeutic targets of abdominal aortic aneurysm: Prospective cohort and Mendelian randomization analyses
Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by permanent, localized dilation of the abdo...
Frailty, genetic susceptibility, and the risk of abdominal aortic aneurysm: Evidence from the UK Biobank cohort study
Abdominal aortic aneurysm (AAA), a life-threatening cardiovascular condition, has become one of the substantial burdens of...
Monocyte to high-density lipoprotein ratio and risk of incident stroke, myocardial infarction, and mortality: A large prospective cohort study
Atherosclerotic cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide [1]. Despite advanc...
Systematic identification of familial hypercholesterolaemia: An updated systematic review and meta-analysis
Background and aimsFamilial hypercholesterolaemia (FH) is an inherited lipid disorder characterised by raised LDL-C and in...
Atheroprotective roles of exercise-regulated microRNAs
Cardiovascular disease remains the leading cause of death worldwide, with atherosclerosis (AS) serving as a critical under...
Valine acts as an early biomarker and exacerbates pathological cardiac hypertrophy by impairing mitochondrial quality control
Hypertension is a significant causative factor of cardiovascular diseases and affects approximately 1.13 billion individua...
KUS121, a novel VCP modulator, attenuates atherosclerosis development by reducing ER stress and inhibiting glycolysis through the maintenance of ATP levels in endothelial cells
Volume 405, June 2025, 119223Author links open overlay panel, , , , , , , , , , , , , , , , , Highlights•The daily treatme...
Accelerated atherosclerosis associated with immune checkpoint inhibitors: a systematic review and meta-analysis of pre-clinical studies
Volume 405, June 2025, 119219Author links open overlay panel, , , , , , , , , , Highlights•Inhibition of co-inhibitory imm...
Minigene splicing reporter assay: a high-stake tool for genetic diagnosis in familial hypobetalipoproteinemia
Hypobetalipoproteinemia (HBL) is characterized by decreased plasma concentrations of low-density lipoprotein cholesterol (...
Small nerve fibre damage and cardiac autonomic dysfunction in patients with hypertriglyceridaemia
Background & objectivesHypertriglyceridaemia (HTG) is an independent risk factor for small fibre neuropathy in patient...
Immune-related biochemical markers and 20-year incidence of atherosclerotic cardiovascular disease: the ATTICA study (2002–2022)
Human immune system baseline activity exhibits remarkable inter-individual variation due to a complex interplay of heritab...
Frequency of residual combined dyslipidemia and hypertriglyceridemia in patients with coronary heart disease in 13 countries across 6 WHO Regions: Results from INTERASPIRE
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality worldwide. Elevated levels ...
Low functional capacity in peripheral artery disease is associated with increased platelet activity and cardiovascular events
Peripheral artery disease (PAD) is a highly prevalent, but underdiagnosed manifestation of systemic atherosclerosis [1,2]....
Interleukin-6 modifies Lipoprotein(a) and oxidized phospholipids associated cardiovascular disease risk in a secondary prevention cohort
Volume 405, June 2025, 119211Author links open overlay panel, , , , , , , , , , , , Highlights•We assessed whether biomark...
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