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Dissecting myocardial and systemic drivers of cardiac dysfunction in the murine CVB3 myocarditis model using microRNA-guided viral detargeting
Dissecting myocardial and systemic drivers of cardiac dysfunction in the murine CVB3 myocarditis model using microRNA-guided viral detargeting
In murine coxsackievirus B3 myocarditis, the most widely used experimental model of viral myocarditis, functional alterati...
Aortic baroreceptor afferents as sensors for systemic inflammation
Aortic baroreceptor afferents as sensors for systemic inflammation
Neuroimmune communication is essential for regulating inflammation and maintaining cardiovascular homeostasis, but the rol...
Coronary endothelial cells undergo venous-enriched disrupted maturation following myocardial infarction
Coronary endothelial cells undergo venous-enriched disrupted maturation following myocardial infarction
The coronary microvascular plexus responds to cardiac ischemia through angiogenic neovascularization in the ischemic and b...
Myofilament-level effects of aficamten increase diastolic chamber volumes and maintain cardiac output through preserved length-dependent force generation in healthy rat and canine myocardium
Myofilament-level effects of aficamten increase diastolic chamber volumes and maintain cardiac output through preserved length-dependent force generation in healthy rat and canine myocardium
Clinical trial experience supports the use of myosin inhibitors in hypertrophic cardiomyopathy (HCM), while early proof-of...
Functional rejuvenation of endothelial cell aging by transient reprogramming
Functional rejuvenation of endothelial cell aging by transient reprogramming
Senescent endothelial cells (ECs), characterized by a reduced angiogenic and regenerative potential, are key players in th...
Bicuspid aortic valve stenosis is characterized by increased angiogenesis, inflammation, and a higher valvular-to-systemic calcification ratio than tricuspid aortic valve stenosis
Bicuspid aortic valve stenosis is characterized by increased angiogenesis, inflammation, and a higher valvular-to-systemic calcification ratio than tricuspid aortic valve stenosis
Calcific aortic valve stenosis is the most common valvular heart disease requiring treatment. Although both tricuspid (AVS...
Peroxisomal catalase and plasmalogen biosynthesis protect from oxidative stress in Barth syndrome cardiomyopathy
Peroxisomal catalase and plasmalogen biosynthesis protect from oxidative stress in Barth syndrome cardiomyopathy
Barth Syndrome (BTHS) is an inherited mitochondrial cardiomyopathy caused by variants in the gene encoding TAFAZZIN (Taz),...
Protection against postoperative atrial fibrillation via antiplatelet aggregation induced by remote ischemic preconditioning during off-pump coronary artery bypass grafting
Protection against postoperative atrial fibrillation via antiplatelet aggregation induced by remote ischemic preconditioning during off-pump coronary artery bypass grafting
Off-pump coronary artery bypass grafting (OPCABG) is associated with increased platelet aggregation and a higher incidence...
Molecular mechanisms of coronary microembolization-induced MINOCA
Molecular mechanisms of coronary microembolization-induced MINOCA
Compared to classic myocardial infarction (cMI), myocardial infarction with non-obstructive coronary arteries (MINOCA) is ...
Cardiac unloading models for myocardial reverse remodeling
Cardiac unloading models for myocardial reverse remodeling
Myocardial reverse remodeling (RR) represents the structural, functional, cellular, and molecular recovery of the failing ...
Cardiomyocyte-specific depletion of integrin α3 preserves cardiac function after myocardial infarction
Cardiomyocyte-specific depletion of integrin α3 preserves cardiac function after myocardial infarction
Integrins, a family of transmembrane receptors that mediate cell-extracellular (ECM) interactions, play a pivotal role in ...
Historical account of reperfusion therapy and the development of cardioprotection beyond reperfusion
Historical account of reperfusion therapy and the development of cardioprotection beyond reperfusion
The only way to salvage myocardium from infarction is timely reperfusion of the occluded coronary artery. Timely reperfusi...
Mesenteric denervation ameliorates post‑infarction heart failure alongside alterations in the gut–nerve–microbiota axis
Mesenteric denervation ameliorates post‑infarction heart failure alongside alterations in the gut–nerve–microbiota axis
Sympathetic overactivity and gut microbiota dysbiosis drive chronic heart failure (CHF) progression. This study explored t...
Meteorin-like regulates cardiac repair via macrophage modulation following myocardial infarction
Meteorin-like regulates cardiac repair via macrophage modulation following myocardial infarction
After myocardial infarction (MI), the heart undergoes a reparative process that includes an initial acute inflammatory pha...
MiR-145-5p modulates collagen production and fibroblast behaviour after cardiac injury partially via COL5A1
MiR-145-5p modulates collagen production and fibroblast behaviour after cardiac injury partially via COL5A1
In contrast to humans, zebrafish hearts after cryoinjury undergo transient fibrotic scarring that subsequently resolves an...
P38α deficiency alleviates myocardial ischemia/reperfusion injury by stabilizing c‑Myc to inhibit ferroptosis
P38α deficiency alleviates myocardial ischemia/reperfusion injury by stabilizing c‑Myc to inhibit ferroptosis
Myocardial ischemia/reperfusion (I/R) injury constitutes a major clinical challenge in ischemic heart disease, and ferropt...
Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure
Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure
During heart failure (HF), gene and protein expression profiles undergo extensive compensatory and pathological remodeling...
TGF-β signalling drives chemotaxis of human induced pluripotent stem cell-derived cardiomyocytes in response to MI stimulus
TGF-β signalling drives chemotaxis of human induced pluripotent stem cell-derived cardiomyocytes in response to MI stimulus
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold significant promise for cardiac regeneration t...
Metabolic dependency of malonate protection against cardiac ischemia–reperfusion injury
Metabolic dependency of malonate protection against cardiac ischemia–reperfusion injury
Malonate, an inhibitor of mitochondrial succinate dehydrogenase (SDH), protects against ischemia–reperfusion injury ...
NLRX1 emerges as the only observed essential regulator of the mPTP, challenging mPTP inhibition as a valid target of cardioprotection
NLRX1 emerges as the only observed essential regulator of the mPTP, challenging mPTP inhibition as a valid target of cardioprotection
The mitochondrial permeability transition pore (mPTP) opening is a phenomenon in which the inner mitochondrial membrane ab...
NLRP3 mediates lipid-driven macrophage proliferation in established atherosclerosis
NLRP3 mediates lipid-driven macrophage proliferation in established atherosclerosis
An increased number of macrophages in the atherosclerotic plaque is associated with plaque instability and plaque progress...
Downregulation of TCF19 and ATAD2 causes endothelial cell cycle arrest at the transition from cardiac hypertrophy to heart failure
Downregulation of TCF19 and ATAD2 causes endothelial cell cycle arrest at the transition from cardiac hypertrophy to heart failure
Cardiac hypertrophy is a key mechanism that allows the heart to adapt to increased load, but in the long term is associate...
The CNP analogue vosoritide mediates PDE2-sensitive anti-arrhythmogenic effects in mouse hearts with STZ-induced type 1 diabetes
The CNP analogue vosoritide mediates PDE2-sensitive anti-arrhythmogenic effects in mouse hearts with STZ-induced type 1 diabetes
Diabetes mellitus induces adverse structural, electrophysiological and autonomic remodelling increasing the risk for life-...
Chemokine–receptor-guided B-cell immunity in cardiovascular disease
Chemokine–receptor-guided B-cell immunity in cardiovascular disease
Cardiovascular diseases (CVD) include a wide range of disorders affecting the heart and blood vessels, many of which are a...
The role of NO, HO, and non-NO/HO mechanisms in acetylcholine (ACh)-induced dilation of human arterioles in the absence and presence of coronary artery disease
The role of NO, HO, and non-NO/HO mechanisms in acetylcholine (ACh)-induced dilation of human arterioles in the absence and presence of coronary artery disease
This study defines the mechanisms of vasodilation to acetylcholine (ACh) in arterioles from patients with and without coro...
Single cell and spatial transcriptomic profiling of the type 2 diabetic coronary microcirculation and myocardium
Single cell and spatial transcriptomic profiling of the type 2 diabetic coronary microcirculation and myocardium
Coronary microvascular disease (CMD) is an early complication of type 2 diabetes (T2D) involving adverse endothelial and s...
Mixed lineage kinase 3 contributes to myocardial ischemia/reperfusion injury by regulating neutrophil activation
Mixed lineage kinase 3 contributes to myocardial ischemia/reperfusion injury by regulating neutrophil activation
Mixed lineage kinase 3 (MLK3), a member of the MAP3K family, is known to participate in cellular stress and inflammatory r...
Autophagy modulates the mechanism of flow-mediated dilation upstream of telomerase
Autophagy modulates the mechanism of flow-mediated dilation upstream of telomerase
The non-canonical functions of telomerase reverse transcriptase (TERT), the catalytic subunit of telomerase play a critica...
Impairment of local metabolic coronary control involves perfusion-contraction matching not supply–demand imbalance
Impairment of local metabolic coronary control involves perfusion-contraction matching not supply–demand imbalance
Understanding of local metabolic control of coronary flow remains stifled by debate around data interpretation and anticip...
Mechanical unloading coupled with coronary reperfusion stimulates cardiomyocyte proliferation and prevents unloading-induced fibrosis after myocardial infarction
Mechanical unloading coupled with coronary reperfusion stimulates cardiomyocyte proliferation and prevents unloading-induced fibrosis after myocardial infarction
Percutaneous left ventricular assist devices (LVADs) have become essential tools during coronary reperfusion in high-risk ...
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