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Bibliometric analysis of the pathogenesis of Parkinson's Disease
Parkinson’s disease (PD), the second most common neurodegenerative disorder worldwide, affects over 10 million individuals...
Antibody-based nanoparticles in Alzheimer’s disease: Innovations in diagnosis and therapy
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to worsening cognitive impairment, and the co...
Modulation of AKT/GSK-3β signaling by ambrisentan alleviates chronic kidney disease
Chronic kidney disease (CKD) represents a progressive impairment of renal function, leading to severe health complications...
Granulocytic myeloid derived suppressor cells derived extracellular vesicles ameliorate DSS-induced colitis via modulation of Th17/Treg balance
Colitis, a form of inflammatory bowel disease (IBD) characterized by inflammation of the colon, has significant clinical a...
CIAPIN1 improves sepsis-induced acute kidney injury by inhibiting mitochondrial damage
Volume 281, May 2026, 156384Author links open overlay panelJingcong Huang 1, Minyu Shi 1, Ziqing Zhang, Zhenyu Xu, Xixiang...
RhoB-Rab1A forms a mechanobiology module that couples cytoskeletal organization to nuclear mechanics and β-catenin access in epithelial cells
Metastatic dissemination remains a principal determinant of outcome in epithelial cancers [1]. Beyond canonical biochemica...
H-DCA Net: Hierarchical dual-branch coordinate attention framework for multi-scale gastric histopathology diagnosis
Gastric cancer is a common and aggressive malignant tumor that poses a significant threat to global health, ranking among ...
Molecular and histopathological insights into renal neuroendocrine tumors (RenNETs): A comprehensive study
Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms that originate from neuroendocrine cells and can arise...
PD-L1 expression across urothelial carcinoma subtypes: A multicenter comparison of 22C3 and SP142 for clinical decision-making in the immunotherapy era
Volume 281, May 2026, 156372Author links open overlay panel, , , , , , , , , Highlights•PD-L1 expression varies across uro...
EASDnet: Empowering human-centered evidence-based medicine through an evidence and attention-based spatial disparity network for discriminative colorectal cancer histopathological screening and attribution
The clinical manifestations of rectal cancer depend on the disease stage. Early-stage rectal cancer is often asymptomatic....
SIRT3 promotes oxaliplatin sensitivity in hepatocellular carcinoma by promoting ferroptosis through endoplasmic reticulum stress response
Hepatocellular Carcinoma (HCC) is a highly lethal primary liver cancer and is one of the most common cancers globally, mai...
Piezo1–PHLPP2–PI3K/AKT axis represents a novel signalling cascade driving EMT and local invasion in colorectal cancer
Epidemiological data identify colorectal cancer as the second leading cause of cancer-related death globally [1], accounti...
Adult ovarian granulosa cell tumor with high-grade hepatoid transformation: Case report and review of literature
Volume 281, May 2026, 156426Author links open overlay panelFan Yang a 1, Jinhua Zheng a 1, Xiaoqian Wang b, Longkuan Xu a,...
Interactions and communications in hepatocellular carcinoma: Potential targets for chemo/radiosensitization
Volume 282, June 2026, 156425Author links open overlay panelXiu Yan, Xiaoying Dong, Liang Yao, Meihua Guo, Ning WangShow m...
Interpreting the ubiquitin signal: Deubiquitinating enzymes in cancer and disease
An active homeostatic system controls numerous intracellular proteins through a complex regulatory system of protein synth...
LGALS3BP promotes M1 polarization of macrophages and interacts with LGALS3, damaging endothelial function and exacerbating pulmonary arterial hypertension in systemic lupus erythematosus
Pulmonary arterial hypertension (PAH) is a serious lung disease caused by fibrosis of pulmonary arterioles and arteries, l...
Astragaloside IV ameliorates experimental autoimmune myasthenia gravis through multi-target regulation of immune-microbiota-metabolism network and ferroptosis inhibition
Myasthenia gravis (MG) is an autoimmune disorder characterized by autoantibody-mediated attack on proteins at the neuromus...
ZDBF2/SIRT6-mediated H3K27 deacetylation inhibits ferroptosis and reduces sensitivity of oral squamous cell carcinoma to cisplatin
Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors of the head and neck globally, characterize...
Inflammation promotes hepatic but not adipose tissue DGAT2 expression and triglyceride synthesis in MAFLD mice
Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction associated fatty liver disease (MAF...
Electroacupuncture mitigates oxidative stress and neuroinflammation in Parkinson's disease via mitigating autophagy-lysosome dysfunction
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder, surpassed in prevalence only by Alzheime...
Molecular carcinogenesis in Hodgkin lymphoma: Interplay between B lymphocyte mutations and NF-κB pathway dysregulation
Hodgkin lymphoma (HL) is an uncommon form of tumor that primarily occurs in young adults, although it can also occur in ol...
Revisiting the biological role of the Warburg effect: Evolving perspectives on cancer metabolism
Cancer cells exhibit metabolic reprogramming towards a glycolysis-dominant profile. This shift, known as the Warburg effec...
Deubiquitinase USP5 regulates cancer progression and radiosensitivity by stabilizing HOXA10 in non-small cell lung cancer
Non-small cell lung cancer (NSCLC), a heterogeneous disease, is a prevalent and malignant tumor with high cancer-related m...
Molecular findings in endometrial mucinous carcinoma of the gastric [Gastrointestinal] type: A report of 5 additional cases and a systematic review of the literature
The authors summarize the somatic mutational landscape of endometrial mucinous carcinoma of the gastric (gastrointestinal)...
Unveiling the enigmatic role of MTBP in pan-cancer: A bioinformatics perspective
MDM2 binding protein (MTBP), a 104 kDa protein with no known functional motifs, was originally identified as a protein tha...
PUM1 enhances PAK6 mRNA stability and contributes to growth and ferroptosis resistance in lung adenocarcinoma cells
Lung cancer represents the most frequent cancer and the leading cause of cancer-related mortalities deaths worldwide in 20...
ZNF671 methylation is a potential regression predictor of cervical intraepithelial neoplasia grade 3 in the colposcopy-to-conization interval
Cervical cancer (CC) is the only cancer that the World Health Organization (WHO) has proposed to eliminate, intending to r...
Alendronate-functionalized ZIF-8 nanoplatform for targeted delivery of SHH siRNA and docetaxel to treat prostate cancer bone metastasis
Volume 273, September 2025, 156138Author links open overlay panel, , , , , , , AbstractSonic hedgehog (SHH) signaling play...
H2-calponin attenuate metastasis in human NSCLC by suppressing RSK2 expression
More than 90 % of human cancer-related deaths are caused by metastasis, a complex process that involves several distinct s...
Nucleus pulposus cell-associated PLAU promotes intervertebral disc degeneration through HIPPO pathway.
IDD is the most common pathological change in various spinal diseases, characterized by a gradual deterioration of disc st...
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