SCI Abstract

search
+
Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour
Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour
Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm molecularly defined by the NAB2::STAT6 gene fusion (GF), an a...
Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulator of tumor immune features and of the KRAS pathway
Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulator of tumor immune features and of the KRAS pathway
Cholesterol dysregulation plays a central role in tumor progression and has emerged as a potential therapeutic target. Its...
Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma
Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma
Glioblastoma (GBM) is the most common adult primary brain tumor for which new therapeutic strategies are desperately neede...
Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma
Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma
Dysregulated cholesterol metabolism has emerged as a crucial driver of hepatocellular carcinoma (HCC) progression and immu...
Discover personalized drug opportunity and optimized tumor-infiltrating lymphocyte therapy for rare cancer: an organoid-based whole-journey clinical mapping study in a neuroendocrine cancer patient
Discover personalized drug opportunity and optimized tumor-infiltrating lymphocyte therapy for rare cancer: an organoid-based whole-journey clinical mapping study in a neuroendocrine cancer patient
Rare cancer patients face dire prognoses due to high malignancy and scarce treatment options, underscoring an imperative f...
Peripheral blood immune cell subsets as non-invasive biomarkers of colorectal cancer stage, laterality, metastasis and survival
Peripheral blood immune cell subsets as non-invasive biomarkers of colorectal cancer stage, laterality, metastasis and survival
Colorectal cancer (CRC) is a heterogeneous disease in which immune dynamics critically influence tumour progression and pa...
Strategies to target PD-1/PD-L1 in the tumor microenvironment
Strategies to target PD-1/PD-L1 in the tumor microenvironment
In recent years, cancer immunotherapy has become one of the most important methods in cancer treatment, which can kill tum...
Hepatocellular carcinoma and vitamin D metabolism: novel targets and therapeutic strategies
Hepatocellular carcinoma and vitamin D metabolism: novel targets and therapeutic strategies
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death worldwide. While age-standardized incidence...
Distinct clinical and genomic profiles of braf mutation subtypes in Chinese colorectal cancer: a retrospective cohort study with cross-population validation
Distinct clinical and genomic profiles of braf mutation subtypes in Chinese colorectal cancer: a retrospective cohort study with cross-population validation
To characterize the clinicogenomic features, prognostic significance and therapeutic implications of BRAF mutation subtype...
B3GNT3 facilitates NFKB2 processing and non-canonical NF-κB activation to drive lung adenocarcinoma progression
B3GNT3 facilitates NFKB2 processing and non-canonical NF-κB activation to drive lung adenocarcinoma progression
Aberrant glycosylation is implicated in tumor progression. However, the role of β-1,3-N-acetylglucosaminyltransferase...
NR2F2/AGAP2 axis: regulating lipid synthesis to drive AML progression via AMPKα/ACC pathway
NR2F2/AGAP2 axis: regulating lipid synthesis to drive AML progression via AMPKα/ACC pathway
This study aims to investigate the role of AGAP2 in acute myeloid leukemia (AML), particularly its involvement in lipid me...
Single-cell transcriptomic mapping of patient-derived primary liver cancer organoids reveals molecular subtypes and guides precision drug targeting
Single-cell transcriptomic mapping of patient-derived primary liver cancer organoids reveals molecular subtypes and guides precision drug targeting
Current liver cancer research lacks reliable in vitro models that replicate tumor pathophysiology. This study establishes ...
Integrated analysis identifies a CXCR6/CD45/PD-1-based risk model for melanoma prognosis and intratumoral CD8+/CD69 + T-cell infiltration correlation
Integrated analysis identifies a CXCR6/CD45/PD-1-based risk model for melanoma prognosis and intratumoral CD8+/CD69 + T-cell infiltration correlation
Currently, relying on a single biomarker to predict the prognosis of melanoma patients is inefficient, particularly in the...
NUAK1 silencing enhances radiotherapy-induced ferroptosis in locally advanced rectal cancer by impairing Nrf2-driven transcription of GPX4
NUAK1 silencing enhances radiotherapy-induced ferroptosis in locally advanced rectal cancer by impairing Nrf2-driven transcription of GPX4
Radiotherapy resistance is a primary cause of treatment failure in locally advanced rectal cancer (LARC). Tumor cells can ...
CircBARD1 suppresses tumor progression driven by H3K18 lactylation-CCNA2 axis in human bladder cancer
CircBARD1 suppresses tumor progression driven by H3K18 lactylation-CCNA2 axis in human bladder cancer
Bladder cancer (BCa) represents the fourth most prevalent malignancy worldwide, characterized by unfavorable clinical outc...
Targeting senescence-like tumor-associated macrophages sensitizes chemotherapy in triple-negative breast cancer
Targeting senescence-like tumor-associated macrophages sensitizes chemotherapy in triple-negative breast cancer
Triple-negative breast cancer (TNBC) frequently develops chemoresistance through poorly understood stromal interactions. T...
Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35
Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35
Glycolytic reprogramming is closely associated with the occurrence and progression of gastric cancer. Specifically, the en...
A habitat radiomics model based on contrast-enhanced MRI for predicting early treatment response to hepatic arterial infusion chemotherapy in patients with unresectable hepatocellular carcinoma
A habitat radiomics model based on contrast-enhanced MRI for predicting early treatment response to hepatic arterial infusion chemotherapy in patients with unresectable hepatocellular carcinoma
To develop a contrast-enhanced Magnetic Resonance Imaging (CEMRI)-based habitat radiomics model for predicting early treat...
CX3CL1-CX3CR1 signaling orchestrates malignant progression of prostate cancer through luminal progenitor-macrophage crosstalk
CX3CL1-CX3CR1 signaling orchestrates malignant progression of prostate cancer through luminal progenitor-macrophage crosstalk
Progression to castration-resistant prostate cancer (CRPC) is shaped by dynamic interactions within the tumor microenviron...
Lenvatinib-activated NDUFA4L2/IL33/PADI4 pathway induces neutrophil extracellular traps that inhibit cuproptosis in hepatocellular carcinoma
Lenvatinib-activated NDUFA4L2/IL33/PADI4 pathway induces neutrophil extracellular traps that inhibit cuproptosis in hepatocellular carcinoma
Lenvatinib is a potent first-line therapy for patients with hepatocellular carcinoma (HCC), but it also increased the numb...
Hepatic arterial infusion chemotherapy (HAIC) combined with Tislelizumab and Lenvatinib for unresectable hepatocellular carcinoma: a retrospective single-arm study
Hepatic arterial infusion chemotherapy (HAIC) combined with Tislelizumab and Lenvatinib for unresectable hepatocellular carcinoma: a retrospective single-arm study
We aimed to explore the curative effects of hepatic arterial infusion chemotherapy (HAIC) combined with Tislelizumab and L...
TRPV4 drives the progression of leiomyosarcoma by promoting ECM1 generation and co-activating the FAK/PI3K/AKT/GSK3β pathway
TRPV4 drives the progression of leiomyosarcoma by promoting ECM1 generation and co-activating the FAK/PI3K/AKT/GSK3β pathway
Leiomyosarcoma (LMS) is an aggressive mesenchymal malignant tumor with poor therapeutic options, but the molecular mechani...
Senolytics: charting a new course or enhancing existing anti-tumor therapies?
Senolytics: charting a new course or enhancing existing anti-tumor therapies?
Cell senescence is a natural response within our organisms. Initially, it was considered an effective anti-tumor mechanism...
Dysregulation of the p53 pathway provides a therapeutic target in aggressive pediatric sarcomas with stem-like traits
Dysregulation of the p53 pathway provides a therapeutic target in aggressive pediatric sarcomas with stem-like traits
Pediatric sarcomas are bone and soft tissue tumors that often exhibit high metastatic potential and refractory stem-like p...
Toxicity profiles of immunochemotherapy for gastric or gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis
Toxicity profiles of immunochemotherapy for gastric or gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis
Neoadjuvant immunochemotherapy is emerging as a promising regimen for patients with locally advanced gastric and gastroeso...
Regulation of AUF1 alternative splicing by hnRNPA1 and SRSF2 modulate the sensitivity of ovarian cancer cells to cisplatin
Regulation of AUF1 alternative splicing by hnRNPA1 and SRSF2 modulate the sensitivity of ovarian cancer cells to cisplatin
Clarification of cisplatin resistance may provide new targets for therapy in cisplatin resistant ovarian cancer. The curre...
Regulatory factor X1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by transcriptional regulation of BECN1
Regulatory factor X1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by transcriptional regulation of BECN1
Sorafenib is a commonly used first-line kinase-targeted drug for advanced hepatocellular carcinoma (HCC) patients sufferin...
Targeting CA9 restricts pancreatic cancer progression through pH regulation and ROS production
Targeting CA9 restricts pancreatic cancer progression through pH regulation and ROS production
Lactate is a key metabolite produced by glycolytic metabolism, yet it also serves as an energy source for cancer cells. La...
Role of BRCA1 in glioblastoma etiology
Role of BRCA1 in glioblastoma etiology
BRCA1 (Breast Cancer 1) is a tumor suppressor gene with a role in DNA repair by Homologous Recombination (HR), and mainten...
The origin of patient-derived cancer organoids from pathologically undiagnosed specimen in patients with pancreatobiliary cancers
The origin of patient-derived cancer organoids from pathologically undiagnosed specimen in patients with pancreatobiliary cancers
Tissue confirmation of pancreatobiliary cancer is often difficult because of the location of the tumor and structure of th...
Load More
format_indent_increase