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Genetic and clinical characteristics of cranial nerve schwannoma harboring fusion gene
Genetic and clinical characteristics of cranial nerve schwannoma harboring fusion gene
The SH3PXD2A-HTRA1 fusion gene has recently been identified in a subset of schwannomas, but its frequency and clinical sig...
Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes
Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes
Oligodendroglial alpha-synuclein (aSyn) deposits are a key feature in the atypical parkinsonian disorder, multiple system ...
In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas
In silico purification improves DNA methylation-based classification rates of pediatric low-grade gliomas
DNA methylation-based classification using the Heidelberg Classifier is a state-of-the-art data-driven method for molecula...
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Tau hyperphosphorylation, a key neuropathological feature of tauopathies such as Alzheimer’s disease (AD), also occu...
Expansion of the spectrum of tumors diagnosed as myxopapillary ependymomas
Expansion of the spectrum of tumors diagnosed as myxopapillary ependymomas
Both spinal ependymomas (SPE) and myxopapillary ependymomas (MPE) exhibit a character...
Evolution of pilocytic astrocytoma to diffuse leptomeningeal glioneuronal tumor (DLGNT): bridging two distinct tumor types
Evolution of pilocytic astrocytoma to diffuse leptomeningeal glioneuronal tumor (DLGNT): bridging two distinct tumor types
DCM and JC receive support from the St. Jude Comprehensive Cancer Center (NCI grant P30CA021765) and American Lebanese Syr...
Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease
Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease
Disturbances within the cerebrovascular system substantially contribute to the pathogenesis of age-related cognitive impai...
Tumor-associated macrophages in meningiomas: a novel biomarker for poor survival outperforming the benefits of T cells
Tumor-associated macrophages in meningiomas: a novel biomarker for poor survival outperforming the benefits of T cells
Tumor-associated macrophages (TAMs) represent the main immune cell population in various brain malignancies, but there is ...
Primary age-related tauopathy
Primary age-related tauopathy
Primary age-related tauopathy (PART) was proposed in 2014 as a neuropathological term to describe patients with Alzheimer&...
Molecular characterization and clinical features of diffuse midline glioma in the pediatric precision oncology registry INFORM
Molecular characterization and clinical features of diffuse midline glioma in the pediatric precision oncology registry INFORM
Diffuse midline glioma (DMG; a subtype of pediatric high-grade glioma) is a fatal disease in children, due to the localiza...
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis
The autophagy–lysosome pathway (ALP) and the ubiquitin–proteasome system (UPS) are the primary protein degrada...
LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies
LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies
Parkinson’s disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with endolysoso...
Brain-derived 5-hydroxymethylcytosine epigenetic scores are related to Alzheimer’s disease pathology and cognitive decline
Brain-derived 5-hydroxymethylcytosine epigenetic scores are related to Alzheimer’s disease pathology and cognitive decline
Cytosine modifications play critical roles in gene regulation and disease pathogenesis. Elucidating novel epigenetic contr...
Alpha-synuclein deposition patterns in Alzheimer’s disease: association with cortical amyloid beta and variable tau load
Alpha-synuclein deposition patterns in Alzheimer’s disease: association with cortical amyloid beta and variable tau load
Alpha-synuclein (α-syn) deposits are common in around half of the Alzheimer’s disease (AD) cases. While direct ...
Spatial protein profiling reveals active roles for astrocytes in the chronic active lesion core during multiple sclerosis
Spatial protein profiling reveals active roles for astrocytes in the chronic active lesion core during multiple sclerosis
Chronic active lesions are a manifestation of multiple sclerosis (MS) and have been associated with disease progression. W...
Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo
Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo
Increased expression of syntaxin-6, a SNARE protein involved in intracellular protein trafficking, is a proposed genetic r...
PolyGR-containing aggregates link with pathology and clinical features of Alzheimer’s disease
PolyGR-containing aggregates link with pathology and clinical features of Alzheimer’s disease
Alzheimer’s disease is the most common form of dementia; however, its molecular mechanisms are not fully understood....
Co-infection with two α-synuclein strains reveals novel synergistic interactions
Co-infection with two α-synuclein strains reveals novel synergistic interactions
In synucleinopathies, the protein α-synuclein misfolds into Lewy bodies (LBs) in patients with Lewy body disease (LBD...
MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma
MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma
Pediatric high-grade glioma (pedHGG) can occur as first manifestation of cancer predisposition syndromes resulting from pa...
IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread
IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread
IDH-mutant astrocytomas are diffuse gliomas that are defined by characteristic mutations in IDH1 or IDH2 and do not have c...
Somatic variants in leading to defects in N-glycosylation in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)
Somatic variants in leading to defects in N-glycosylation in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)
Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is a new histopathological...
fusion driver in primary central nervous system malignancy: case report
fusion driver in primary central nervous system malignancy: case report
Andreiuolo F, Varlet P, Tauziède-Espariat A, Jünger ST, Dörner E et al (2019) Childhood supratentorial ependymomas with YA...
Perivascular glial reactivity is a feature of phosphorylated tau lesions in chronic traumatic encephalopathy
Perivascular glial reactivity is a feature of phosphorylated tau lesions in chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE), a neurodegenerative disease associated with repetitive head injuries, is character...
A novel fusion that potentially expands the concept of supratentorial ependymoma, fusion-positive
A novel fusion that potentially expands the concept of supratentorial ependymoma, fusion-positive
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Brain tissue metal concentrations and Alzheimer’s disease neuropathology in total joint arthroplasty patients versus controls
Brain tissue metal concentrations and Alzheimer’s disease neuropathology in total joint arthroplasty patients versus controls
We examined whether total joint arthroplasty (TJA) is associated with increased metal accumulation in the brain and histop...
Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus
Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus
In Alzheimer’s disease (AD), microglia form distinct cellular aggregates that play critical roles in disease progres...
A quantitative Lewy-fold-specific alpha-synuclein seed amplification assay as a progression marker for Parkinson’s disease
A quantitative Lewy-fold-specific alpha-synuclein seed amplification assay as a progression marker for Parkinson’s disease
Misfolded α-synuclein (αSyn) is the hallmark of α-synucleinopathies such as Parkinson’s disease (PD),...
Evidence of COMT dysfunction in the olfactory bulb in Parkinson’s disease
Evidence of COMT dysfunction in the olfactory bulb in Parkinson’s disease
Hyposmia is one of the most prevalent non-motor symptoms of Parkinson’s disease and antecedes motor dysfunction by u...
Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model
Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model
Atypical wild-type superoxide dismutase 1 (SOD1) protein misfolding and deposition occurs specifically within the degenera...
Human brain tissue with MOGHE carrying somatic variants reveal aberrant protein expression and protein loss in the white matter
Human brain tissue with MOGHE carrying somatic variants reveal aberrant protein expression and protein loss in the white matter
Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) is a recently described di...
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