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Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease
Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease
AbstractObjectives Hypocomplementaemia is common in patients with IgG4-related disease (IgG4-RD). We aimed to determine th...
Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial
Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial
WHAT IS ALREADY KNOWN ON THIS TOPICRheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) serology are impo...
Guselkumab in Behcets disease
Guselkumab in Behcets disease
The mucocutaneous and articular clinical phenotype is the most common presentation of Behçet’s disease (BD).1 Current trea...
Mystery of hidden pearls: bursitis in the shoulder
Mystery of hidden pearls: bursitis in the shoulder
A woman aged 52 years, known to have rheumatoid arthritis for 12 years, presented with worsening of joint pain for 2 weeks...
Journey through discovery of 75 years glucocorticoids: evolution of our knowledge of glucocorticoid receptor mechanisms in rheumatic diseases
Journey through discovery of 75 years glucocorticoids: evolution of our knowledge of glucocorticoid receptor mechanisms in rheumatic diseases
StarterRaoul Dufy received corticosteroid therapy in 1950 as one of the first patients to be treated with cortisone to rel...
Ruxolitinib as a salvage therapy in adult-onset macrophage activation syndrome: insights from eight cases
Ruxolitinib as a salvage therapy in adult-onset macrophage activation syndrome: insights from eight cases
Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic disorder characteristic by excessive ...
Systemic juvenile idiopathic arthritis and adult-onset Stills disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Stills disease
Systemic juvenile idiopathic arthritis and adult-onset Stills disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Stills disease
IntroductionStill’s disease was described in children in 1897 by Sir George Frederick Still and is today called systemic j...
Efficacy and safety of therapies for Stills disease and macrophage activation syndrome (MAS): a systematic review informing the EULAR/PReS guidelines for the management of Stills disease
Efficacy and safety of therapies for Stills disease and macrophage activation syndrome (MAS): a systematic review informing the EULAR/PReS guidelines for the management of Stills disease
IntroductionAdult-onset Still’s disease (AOSD) and systemic juvenile idiopathic arthritis (sJIA) are the adult and child c...
Plasma proteome profiling in giant cell arteritis
Plasma proteome profiling in giant cell arteritis
IntroductionEarly in its disease course, giant cell arteritis (GCA) can cause irreversible vision loss and cerebrovascular...
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood
Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3, the gene responsible for progressive pseudorheumatoid arthropathy of childhood
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Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
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Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis
Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis
IntroductionSynovitis is the clinical hallmark of rheumatoid arthritis (RA), and the analysis of synovial tissue from affe...
Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits
Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits
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Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)
Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3)
IntroductionDespite the range of disease-modifying anti-rheumatic drugs (DMARDs) that have transformed the therapeutic lan...
Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism
Spanish cohort of VEXAS syndrome: clinical manifestations, outcome of treatments and novel evidences about UBA1 mosaicism
IntroductionAutoinflammatory diseases (AIDs) are genetically determined conditions characterised by recurrent sterile infl...
Correspondence on 'The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease by Wallace et al
Correspondence on 'The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease by Wallace et al
IgG4-related disease (IgG4-RD) was initially discovered as a clearly different entity in patients with sclerosing cholangi...
Correspondence on 'NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus by Linge et al
Correspondence on 'NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus by Linge et al
We read with great interest the article by Linge et al 1 on ‘NCF1- 339 polymorphism is associated with altered formation o...
Lessons from negative phase 3 trials in rheumatoid arthritis anno 2023
Lessons from negative phase 3 trials in rheumatoid arthritis anno 2023
A recent phase 3 trial (contRAst 3) with otilimab, a drug targeting granulocyte-macrophage colony-stimulating factor (GM-C...
Potential for biosimilars in rheumatology in Africa
Potential for biosimilars in rheumatology in Africa
Biosimilars are products which are highly similar to a reference biologic product (RBP). In Africa, regulatory frameworks ...
Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2)
Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2)
WHAT IS ALREADY KNOWN ON THIS TOPICNot all patients with rheumatoid arthritis (RA) achieve effective disease control with ...
Contributions of joint damage-related events to gout pathogenesis: new insights from laboratory research
Contributions of joint damage-related events to gout pathogenesis: new insights from laboratory research
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Finger ischaemia, enlarged spleen and lung nodules
Finger ischaemia, enlarged spleen and lung nodules
A 48-year-old man presented with a 10 kg weight loss and fever. On examination, there was digital ischaemia (figure 1), oe...
Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink
Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink
WHAT IS ALREADY KNOWN ON THIS TOPICColchicine or non-steroidal anti-inflammatory drug prophylaxis reduces the incidence of...
Correspondence on "Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial" by Molto et al
Correspondence on "Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial" by Molto et al
With great interest, we read the results of the tight control in spondyloarthritis (TICOSPA) study1 in which a tight-contr...
Anti-cyclic citrullinated peptide antibody and pain sensitisation in patients with rheumatoid arthritis: a cross-sectional analysis
Anti-cyclic citrullinated peptide antibody and pain sensitisation in patients with rheumatoid arthritis: a cross-sectional analysis
Pain and inflammation are often discordant among patients with rheumatoid arthritis (RA). In a mouse model, systemic injec...
Benralizumab for eosinophilic granulomatosis with polyangiitis
Benralizumab for eosinophilic granulomatosis with polyangiitis
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Single-cell analysis reveals key differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroups
Single-cell analysis reveals key differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroups
IntroductionThe extent and severity of skin thickness varies in systemic sclerosis (SSc). In diffuse cutaneous SSc (dcSSc)...
Dupilumab for relapsing or refractory sinonasal and/or asthma manifestations in eosinophilic granulomatosis with polyangiitis: a European retrospective study
Dupilumab for relapsing or refractory sinonasal and/or asthma manifestations in eosinophilic granulomatosis with polyangiitis: a European retrospective study
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Clinical image: atypical calcification of dorsal spine
Clinical image: atypical calcification of dorsal spine
A previously healthy 46-year-old man presented with constant and awakening dorsal pain and fever for 5 days. There was no ...
Time and dose-dependent effect of systemic glucocorticoids on major adverse cardiovascular event in patients with rheumatoid arthritis: a population-based study
Time and dose-dependent effect of systemic glucocorticoids on major adverse cardiovascular event in patients with rheumatoid arthritis: a population-based study
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSIn this population-based real-world database, after controlling for...
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