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Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1/PKA/CREB to promote inflammation and catabolism
Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1/PKA/CREB to promote inflammation and catabolism
Metabolic Syndrome (MetS), as a syndrome characterized by low-grade inflammation and energy metabolism disorders, is consi...
Recent advances in omics and the integration of multi-omics in osteoarthritis research
Recent advances in omics and the integration of multi-omics in osteoarthritis research
Osteoarthritis (OA) is a complex disorder driven by the combination of environmental and genetic factors. Given its high g...
Smoking as a risk factor for rheumatoid arthritis: predominant association with IgA autoantibodies – comprehensive analysis of anti-modified protein antibodies with smoking and genetic risk factors in rheumatoid arthritis
Smoking as a risk factor for rheumatoid arthritis: predominant association with IgA autoantibodies – comprehensive analysis of anti-modified protein antibodies with smoking and genetic risk factors in rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of autoantibodies against modified protei...
CAR-T cell therapy for juvenile-onset autoimmune diseases: a promising future?
CAR-T cell therapy for juvenile-onset autoimmune diseases: a promising future?
Chimeric antigen receptor (CAR) T-cell therapy targeting B cells has shown promising results, including drug-free remissio...
Gender differences in clinical and prescribing characteristics of biologic and targeted synthetic drugs in naïve patients with rheumatoid arthritis: Data from BIOBADASER III registry
Gender differences in clinical and prescribing characteristics of biologic and targeted synthetic drugs in naïve patients with rheumatoid arthritis: Data from BIOBADASER III registry
Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease that can lead to progressive joint damage ...
Clinical phenotypes and prognoses of microscopic polyangiitis based on kidney biopsies
Clinical phenotypes and prognoses of microscopic polyangiitis based on kidney biopsies
To classify the different clinical phenotypes and compare the distinct prognoses of microscopic polyangiitis (MPA). A retr...
Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization
Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization
While joint immobilization is a useful repair method for intra-articular ligament injury and periarticular fracture, prolo...
Efficient delivery of the lncRNA LEF1-AS1 through the antibody LAIR-1 (CD305)-modified Zn-Adenine targets articular inflammation to enhance the treatment of rheumatoid arthritis
Efficient delivery of the lncRNA LEF1-AS1 through the antibody LAIR-1 (CD305)-modified Zn-Adenine targets articular inflammation to enhance the treatment of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovial hyperplasia. Maintaining ...
Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse
Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse
Our preliminary study indicates that the multi-functional protein, prokineticin 2 (Prok2), is upregulated in osteoarthriti...
Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)
Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)
To identify the role of gluconeogenesis in chondrocytes in osteoarthritis (OA). Cartilage samples were collected from OA p...
Machine learning and molecular subtype analyses provide insights into PANoptosis-associated genes in rheumatoid arthritis
Machine learning and molecular subtype analyses provide insights into PANoptosis-associated genes in rheumatoid arthritis
PANoptosis represents a newly identified form of programmed cell death that plays a significant role in the autoimmune dis...
Age-dependent genetic regulation of osteoarthritis: independent effects of immune system genes
Age-dependent genetic regulation of osteoarthritis: independent effects of immune system genes
Osteoarthritis (OA) is a joint disease with a heritable component. Genetic loci identified via genome-wide association stu...
Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment
Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment
Currently, it is not possible to predict whether patients with hyperuricemia (HUA) will develop gout and how this progress...
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation
Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation
Innate immunity plays a significant role in the pathogenesis of temporomandibular joint osteoarthritis (TMJOA), which is c...
The relation between synovitis of individual finger joints and grip force over the first 5 years in early rheumatoid arthritis — a cohort study
The relation between synovitis of individual finger joints and grip force over the first 5 years in early rheumatoid arthritis — a cohort study
The objective of this study was to investigate the relation between swelling and tenderness of individual finger joints an...
Characterization of human placenta-derived exosome (pExo) as a potential osteoarthritis disease modifying therapeutic
Characterization of human placenta-derived exosome (pExo) as a potential osteoarthritis disease modifying therapeutic
Human placenta-derived exosomes (pExo) were generated, characterized, and evaluated as a therapeutic candidate for the tre...
Long-term follow-up of children with chronic non-bacterial osteomyelitis—assessment of disease activity, risk factors, and outcome
Long-term follow-up of children with chronic non-bacterial osteomyelitis—assessment of disease activity, risk factors, and outcome
Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory bone-disease of unknown origin. The National Pediatric Rh...
Differential expression pattern of Bcl-2 family members in B and T cells in systemic lupus erythematosus and rheumatoid arthritis
Differential expression pattern of Bcl-2 family members in B and T cells in systemic lupus erythematosus and rheumatoid arthritis
This study aimed to evaluate the expression level of anti-apoptotic Bcl-2 family proteins in B and T cells in patients wit...
Assessing clusters of comorbidities in rheumatoid arthritis: a machine learning approach
Assessing clusters of comorbidities in rheumatoid arthritis: a machine learning approach
Comorbid conditions are very common in rheumatoid arthritis (RA) and several prior studies have clustered them using machi...
Assessment of axial spondyloarthritis activity using a magnetic resonance imaging-based multi-region-of-interest fusion model
Assessment of axial spondyloarthritis activity using a magnetic resonance imaging-based multi-region-of-interest fusion model
Identifying axial spondyloarthritis (axSpA) activity early and accurately is essential for treating physicians to adjust t...
Impact of IL6R genetic variants on treatment efficacy and toxicity response to sarilumab in rheumatoid arthritis
Impact of IL6R genetic variants on treatment efficacy and toxicity response to sarilumab in rheumatoid arthritis
Sarilumab, an IL-6 receptor antagonist, is a first-line biologic disease-modifying anti-rheumatic drug for rheumatoid arth...
Risk prediction model for mortality in microscopic polyangiitis: multicentre REVEAL cohort study
Risk prediction model for mortality in microscopic polyangiitis: multicentre REVEAL cohort study
To establish refined risk prediction models for mortality in patients with microscopic polyangiitis (MPA) by using compreh...
Prevalence and predictors of sustained remission/low disease activity after discontinuation of induction or maintenance treatment with tumor necrosis factor inhibitors in rheumatoid arthritis: a systematic and scoping review
Prevalence and predictors of sustained remission/low disease activity after discontinuation of induction or maintenance treatment with tumor necrosis factor inhibitors in rheumatoid arthritis: a systematic and scoping review
To determine the prevalence of sustained remission/low disease activity (LDA) in patients with rheumatoid arthritis (RA) a...
Establishment of a differential diagnosis method and an online prediction platform for AOSD and sepsis based on gradient boosting decision trees algorithm
Establishment of a differential diagnosis method and an online prediction platform for AOSD and sepsis based on gradient boosting decision trees algorithm
The differential diagnosis between adult-onset Still’s disease (AOSD) and sepsis has always been a challenge. In thi...
TIGIT reverses IFN-α-promoted Th1-like Tregs via in-sequence effects dependent on STAT4
TIGIT reverses IFN-α-promoted Th1-like Tregs via in-sequence effects dependent on STAT4
The induction direction of interferon (IFN)-α in T-cell phenotype and function varies depending on the activation sta...
Bruton’s tyrosine kinase is a possible therapeutic target in microscopic polyangiitis
Bruton’s tyrosine kinase is a possible therapeutic target in microscopic polyangiitis
Bruton’s tyrosine kinase (Btk) is an enzyme expressed in leukocytes other than T lymphocytes and plasma cells and in...
Regenerative effects of platelet-rich plasma releasate injection in rabbit discs degenerated by intradiscal injection of condoliase
Regenerative effects of platelet-rich plasma releasate injection in rabbit discs degenerated by intradiscal injection of condoliase
Intradiscal condoliase injection is an alternative therapeutic option for lumbar disc herniation (LDH). However, it is oft...
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway
The aggressive phenotype of fibroblast-like synoviocytes (FLS) has been identified as a contributing factor to the exacerb...
Rheumatoid arthritis increases the risk of malignant neoplasm of bone and articular cartilage: a two-sample bidirectional mendelian randomization study
Rheumatoid arthritis increases the risk of malignant neoplasm of bone and articular cartilage: a two-sample bidirectional mendelian randomization study
Prior research has revealed a heightened prevalence of neoplasms in individuals diagnosed with rheumatoid arthritis (RA). ...
Retraction Note: Combined effect of genetic background and gender in a mouse model of bleomycin-induced skin fibrosis
Retraction Note: Combined effect of genetic background and gender in a mouse model of bleomycin-induced skin fibrosis
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13075-023-0321...
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