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Adjunctive glucocorticoids in Kawasaki disease
In a phase III trial, the addition of glucocorticoids to standard therapy did not prevent the development of coronary arte...
Lytic cell death turns TRIM21 into an autoantigen
Findings show that lytic cell death releases TRIM21, promoting immune complex uptake by macrophages and autoimmune inflamm...
Treatment strategies in giant cell arteritis and polymyalgia rheumatica: beyond glucocorticoids
Treatment strategies in giant cell arteritis and polymyalgia rheumatica: beyond glucocorticoids
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are closely related chronic inflammatory conditions. Glucocort...
Treat-to-target in Behçet syndrome
Treat-to-target in Behçet syndrome
Behçet syndrome is a complex systemic immune-mediated form of vasculitis characterized by diverse clinical manifestat...
Decoding variants of uncertain significance in systemic autoinflammatory diseases
Decoding variants of uncertain significance in systemic autoinflammatory diseases
The development and implementation of genetic testing has revolutionized the diagnostic landscape of autoinflammatory dise...
Type I interferon mediates autoimmune photosensitivity
A study provides insights into the mechanisms that underlie photosensitivity in cutaneous lupus erythematosus and dermatom...
Rethinking early-stage knee osteoarthritis beyond radiography
Rethinking early-stage knee osteoarthritis beyond radiography
Symptomatic knee osteoarthritis at an early structural stage could provide a window of opportunity for intervention. Sympt...
The evolving comorbidity landscape of rheumatoid arthritis
The evolving comorbidity landscape of rheumatoid arthritis
Rheumatoid arthritis (RA) is associated with a wide spectrum of comorbidities that substantially influence quality of life...
DADA2 as an autosomal dominant disease
Although DADA2 is typically described as an autosomal recessive disease, it can also present in individuals who are hetero...
In vivo CAR-T cell engineering in refractory SLE
Infused lipid nanoparticles were successfully used to generate CAR-T cells in patients with refractory systemic lupus eryt...
STING-driven necroptosis linked to autoinflammatory disease
Findings demonstrate that STING mediates necroptosis in the context of autoinflammatory disease, and suggest a potential t...
Advancing rheumatic disease care through generative artificial intelligence
Generative artificial intelligence promises to reshape clinical care in rheumatology by supporting diagnostic reasoning, t...
Potential benefit of anticoagulation in Behçet syndrome
We read with great interest the comprehensive Review by Bello et al. published in Nature Reviews Rheumatology1. The author...
Reply to ‘Potential benefit of anticoagulation in Behçet syndrome’
Department of Internal Medicine 3, Friedrich-Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Er...
Biological and clinical roles of IL-18 in inflammatory diseases
Biological and clinical roles of IL-18 in inflammatory diseases
Several new discoveries have revived interest in the pathogenic potential and possible clinical roles of IL-18. IL-18 is a...
Nanohybrid therapy hits multiple arthritis targets
A novel combination of ceria nanoparticles and mesenchymal stem cell nanovesicles modified both inflammation and autoimmun...
Shifting the SLE management paradigm: challenges and implications
Shifting the SLE management paradigm: challenges and implications
Newly published European guidelines for the management of systemic lupus erythematosus (SLE) and lupus nephritis, specific...
Primary care rheumatology: towards sustainable development in health
Globally, rheumatic musculoskeletal diseases constitute the most common causes of disability, related morbidity and econom...
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress
Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of derm...
Profiling joint tissues at single-cell resolution: advances and insights
Profiling joint tissues at single-cell resolution: advances and insights
Advances in the profiling of human joint tissues at single-cell resolution have provided unique insights into the organiza...
Targeted NOD2 sequencing uncovers JIA misdiagnosis
New findings support the use of targeted next-generation sequencing of NOD2 to reassess the diagnosis of juvenile idiopath...
Single-cell atlas unveils the diversity of RA synovial tissue
Researchers have conducted a comprehensive single-cell analysis of synovial tissue in rheumatoid arthritis, providing insi...
Multi-omics reveals distinct MPA subtypes
Using multi-omics analyses, researchers have identified two distinct immunological phenotypes of microscopic polyangiitis,...
l-arginine inhibits arthritis and bone loss by reprogramming osteoclast metabolism
New research shows that the amino acid l-arginine ameliorates arthritis and inhibits inflammatory bone loss by altering en...
Predominant ligament-centric soft-tissue involvement differentiates axial psoriatic arthritis from ankylosing spondylitis
Predominant ligament-centric soft-tissue involvement differentiates axial psoriatic arthritis from ankylosing spondylitis
Since the original description of spondyloarthritis 50 years ago, results have demonstrated similarities and differences b...
25 years of biologic DMARDs in rheumatology
25 years of biologic DMARDs in rheumatology
2023 marks 25 years since the approval of the first biologic drug in rheumatology. In this Viewpoint, five rheumatology re...
Immune mechanisms of depression in rheumatoid arthritis
Immune mechanisms of depression in rheumatoid arthritis
Depression is a common and disabling comorbidity in rheumatoid arthritis that not only decreases the likelihood of remissi...
Systemic sclerosis interstitial lung disease: unmet needs and potential solutions
Systemic sclerosis interstitial lung disease: unmet needs and potential solutions
Systemic sclerosis (SSc), or scleroderma, is a rare, complex, systemic autoimmune disease of unknown aetiology, characteri...
Treatment of systemic juvenile idiopathic arthritis
Treatment of systemic juvenile idiopathic arthritis
Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory disease with hallmarks of severe systemic inflammation, w...
International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative
International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative
Adult-onset idiopathic inflammatory myopathy (IIM) is associated with an increased cancer risk within the 3 years precedin...
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