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Human Macrophage Long Intergenic Noncoding RNA, SIMALR, Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1)
Background: Long noncoding RNAs (lncRNAs) have emerged as novel regulators of macrophage biology and inflammatory cardiova...
Hepatic Activin A: An Exciting Target for Cardiometabolic Health
"Hepatic Activin A: An Exciting Target for Cardiometabolic Health." Arteriosclerosis, Thrombosis, and Vascular Biology, , ...
Immature Platelet Fraction Predicts Adverse Events in Patients With Acute Coronary Syndrome: the ISAR-REACT 5 Reticulated Platelet Substudy
BACKGROUND: Immature or reticulated platelets are associated with impaired efficacy of antiplatelet drugs and adverse even...
Response by Owens and Deaton to Letter Regarding Article, “Dichotomous Roles of Smooth Muscle Cell–Derived MCP1 (Monocyte Chemoattractant Protein 1) in Development of Atherosclerosis”
"Response by Owens and Deaton to Letter Regarding Article, “Dichotomous Roles of Smooth Muscle Cell–Derived MCP1 (Monocyte...
Hypercholesterolemic Dysregulation of Calpain in Lymphatic Endothelial Cells Interferes With Regulatory T-Cell Stability and Trafficking
Background: Although hypercholesterolemia reportedly counteracts lymphocyte trafficking across lymphatic vessels, the role...
Bicuspid Aortic Valve–Associated Regulatory Regions Reveal GATA4 Regulation and Function During Human-Induced Pluripotent Stem Cell–Based Endothelial-Mesenchymal Transition
BACKGROUND: The endothelial-mesenchymal transition (EndoMT) is a fundamental process for heart valve formation and defects...
Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4–Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis
Background: Inappropriate activation and aggregation of platelets can lead to arterial thrombosis. Thrombin is the most po...
New Autosomal Myh11-CreER T2 Smooth Muscle Cell Lineage Tracing and Gene Knockout Mouse Model
Background: The Myh11 promoter is extensively used as a smooth muscle cell (SMC) Cre-driver and is regarded as the most re...
Blood Pressure Responses During Exercise: Physiological Correlates and Clinical Implications
Background: Abnormal blood pressure (BP) responses to exercise can predict adverse cardiovascular outcomes, but their opti...
Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels
Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels
Background: The harmful vascular effects of smoking are well established, but the effects of chronic use of electronic cig...
How Irritating! Electronic Cigarettes Not “95% Safer” Than Combustible Cigarettes: Recent Mechanistic Insights Into Endothelial Dysfunction
How Irritating! Electronic Cigarettes Not “95% Safer” Than Combustible Cigarettes: Recent Mechanistic Insights Into Endothelial Dysfunction
Daniel J. Conklin Correspondence to: Daniel J. Conklin, PhD, Center for Cardiometabolic Science, 580 S. Preston St, Delia ...
TMEM100, a Lung-Specific Endothelium Gene
Zhiyu Dai Correspondence to: Zhiyu Dai, PhD, Department of Internal Medicine, College of Medicine-Phoenix, University of A...
Arginase-1 Deletion in Erythrocytes Promotes Vascular Calcification via Enhanced GSNOR (S-Nitrosoglutathione Reductase) Expression and NO Signaling in Smooth Muscle Cells
BACKGROUND: Erythrocytes (red blood cells) participate in the control of vascular NO bioavailability. The purpose of this ...
Specific Loss of ABCA1 (ATP-Binding Cassette Transporter A1) Suppresses TCR (T-Cell Receptor) Signaling and Provides Protection Against Atherosclerosis
Background: ABCA1 (ATP-binding cassette transporter A1) mediates cholesterol efflux to apo AI to maintain cellular cholest...
Cellular Landscapes of Nondiseased Human Cardiac Valves From End-Stage Heart Failure–Explanted Heart
Background: Exploring the mechanisms of valvular heart disease at the cellular level may be useful to identify new therape...
New Genomic Techniques Provide Novel Insights Into Ascending Aortic Aneurysm Pathology
Jonathan Golledge Correspondence to: Jonathan Golledge, MB, BChir, MChir, Queensland Research Centre for Peripheral Vascul...
Nonproteolytic Intracellular Domain of MT1-MMP (Membrane-Type 1 Matrix Metalloproteinase) Coordinately Modulates Abdominal Aortic Aneurysm and Atherosclerosis to Mice
Background: MT1-MMP (membrane-type 1 matrix metalloproteinase, MMP-14) is a transmembrane-anchored protein with an extrace...
Novel Target for Limiting VEGF-A (Vascular Endothelial Growth Factor A)–Induced Vascular Permeability
Joyce Bischoff Correspondence to: Joyce Bischoff, PhD, Karp Family Research Laboratories 12.212, Boston Children’s Hospita...
Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile–Induced Thoracic Aortopathy in Mice
BACKGROUND: Cross-linking of lysine residues in elastic and collagen fibers is a vital process in aortic development. Inhi...
High-Density Lipoprotein and Long-Term Incidence and Progression of Aortic Valve Calcification: The Multi-Ethnic Study of Atherosclerosis
Background: Aortic valve calcification (AVC) shares pathological features with atherosclerosis. Lipoprotein components hav...
Calcium-Controlled Reactive Oxygen Species Afterburner Perpetuates Endothelial Damage After Radiation Therapy
Ralf P. Brandes Correspondence to: Ralf P. Brandes, Institute Kardiovaskuläre Physiologie, Fachbereich Medizin, Goethe-Uni...
Mitochondrial Ca2+ Uptake Drives Endothelial Injury By Radiation Therapy
Background: Radiation therapy strongly increases the risk of atherosclerotic vascular disease, such as carotid stenosis. R...
Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic Aneurysm
Background: Aortic root smooth muscle cells (SMC) develop from both the second heart field (SHF) and neural crest. Dispara...
Lgals3-Transitioned Inflammatory Smooth Muscle Cells: Major Regulators of Atherosclerosis Progression and Inflammatory Cell Recruitment
Mary C.M. Weiser-Evans Correspondence to: Mary C.M. Weiser-Evans, Department of Medicine, Division of Renal Diseases and H...
ENPP2 (Endothelial Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Increases Atherosclerosis in Female and Male Mice
BACKGROUND: Maladapted endothelial cells (ECs) secrete ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2; autotaxi...
Epicardial Adipose Tissue Ceramides Are Related to Lipoprotein Lipase Activity in Coronary Artery Disease: Unfolding a Missing Link
Background: Epicardial adipose tissue (EAT) contributes to coronary artery disease (CAD). EAT presents a specific lipidomi...
PIKfyve-Dependent Phosphoinositide Dynamics in Megakaryocyte/Platelet Granule Integrity and Platelet Functions
BACKGROUND: Secretory granules are key elements for platelet functions. Their biogenesis and integrity are regulated by fi...
Preventing Cholesterol-Induced Perk (Protein Kinase RNA-Like Endoplasmic Reticulum Kinase) Signaling in Smooth Muscle Cells Blocks Atherosclerotic Plaque Formation
BACKGROUND: Vascular smooth muscle cells (SMCs) undergo complex phenotypic modulation with atherosclerotic plaque formatio...
Microarchitectural Changes of Cardiovascular Calcification in Response to In Vivo Interventions Using Deep-Learning Segmentation and Computed Tomography Radiomics
BACKGROUND: Coronary calcification associates closely with cardiovascular risk, but its progress is accelerated in respons...
Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists With Platelet PAR (Protease-Activated Receptor)-1 and PAR-4–Mediated Thrombin Resistance
Background: Thrombin (via PAR [protease-activated receptor]-1 and PAR-4) and ADP (via P2Y12 receptors) are potent endogeno...
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