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When it comes to the heart, age and sex matter (sometimes)
When it comes to the heart, age and sex matter (sometimes)
Received 22 December 2022 ...
Glial cell activity in cardiovascular diseases and risk of acute myocardial infarction
Glial cell activity in cardiovascular diseases and risk of acute myocardial infarction
Growing evidence indicates that the pathophysiological link between the brain and heart underlies cardiovascular diseases,...
Iron chelation therapy to prevent poststroke cognitive impairments: role of diabetes and sex
Iron chelation therapy to prevent poststroke cognitive impairments: role of diabetes and sex
Department of Pharmacology, Tulane University School of Medicine, New Orleans, LouisianaNeuroscience Program, Tulane Brain...
Deferoxamine prevents poststroke memory impairment in female diabetic rats: potential links to hemorrhagic transformation and ferroptosis
Deferoxamine prevents poststroke memory impairment in female diabetic rats: potential links to hemorrhagic transformation and ferroptosis
The current study shows for the first time that diabetes does not promote aberrant cerebrovascularization in female rats. ...
Increased length-dependent activation of human engineered heart tissue after chronic α1A-adrenergic agonist treatment: testing a novel heart failure therapy
Increased length-dependent activation of human engineered heart tissue after chronic α1A-adrenergic agonist treatment: testing a novel heart failure therapy
Chronic stimulation of cardiac a1A-adrenergic receptors (a1A-ARs) improves symptoms in multiple preclinical models of hear...
Improving the Inclusion of Transgender & Non-Binary Individuals in the Planning, Completion and Mobilization of Cardiovascular Research
Improving the Inclusion of Transgender & Non-Binary Individuals in the Planning, Completion and Mobilization of Cardiovascular Research
Cardiovascular disease is the leading cause of morbidity and mortality globally. Transgender and non-binary (TNB) individu...
Iron Chelation Therapy to Prevent Post-Stroke Cognitive Impairments: Role of Diabetes and Sex
Iron Chelation Therapy to Prevent Post-Stroke Cognitive Impairments: Role of Diabetes and Sex
* Corresponding Author; email: [email protected]1Department of Pharmacology, Tulane University School of Medicine, New Orl...
A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
Left ventricular (LV) dysfunction is an early, clinically detectable sign of cardiomyopathy in type 2 diabetes mellitus (T...
Comprehensive Ultrasound Imaging of Right Ventricular Remodeling Under Surgically Induced Pressure Overload in Mice
Comprehensive Ultrasound Imaging of Right Ventricular Remodeling Under Surgically Induced Pressure Overload in Mice
This study reports a new methodology for right heart imaging by ultrasound in mice under right ventricular (RV) pressure o...
17β-Estradiol Promotes Sex-Specific Dysfunction in Isolated Human Arterioles
17β-Estradiol Promotes Sex-Specific Dysfunction in Isolated Human Arterioles
Despite data showing that estrogen is vasculoprotective in large conduit arteries, hormone therapy (HT) during menopause h...
Empagliflozin attenuates arrhythmogenesis in diabetic cardiomyopathy by normalizing intracellular Ca2+ handling in ventricular cardiomyocytes
Empagliflozin attenuates arrhythmogenesis in diabetic cardiomyopathy by normalizing intracellular Ca2+ handling in ventricular cardiomyocytes
Diabetic cardiomyopathy has been reported to increase the risk of fatal ventricular arrhythmia. The beneficial effects of ...
Enhanced protein acetylation initiates fatty acid-mediated inhibition of cardiac glucose transport
Enhanced protein acetylation initiates fatty acid-mediated inhibition of cardiac glucose transport
Fatty acids (FAs) rapidly and efficiently reduce cardiac glucose uptake in the Randle cycle or glucose-FA cycle. This fine...
An in silico approach to understanding the interaction between cardiovascular and pulmonary lymphatic dysfunction
An in silico approach to understanding the interaction between cardiovascular and pulmonary lymphatic dysfunction
The lung is extremely sensitive to interstitial fluid balance, yet the role of pulmonary lymphatics in lung fluid homeosta...
Modeling incomplete penetrance in long QT syndrome type 3 through ion channel heterogeneity: an in silico population study
Modeling incomplete penetrance in long QT syndrome type 3 through ion channel heterogeneity: an in silico population study
An in silico population approach investigates the relationship between variability in ion channel expression and gain-of-f...
One method does not fit all: the importance of sex and using multiple methods to assess cardiac reserve in mice
One method does not fit all: the importance of sex and using multiple methods to assess cardiac reserve in mice
Received 19 December 2022 ...
Toward bedside computation of myocardial infarction risk using noninvasive analysis of patients living with coronary artery disease
Toward bedside computation of myocardial infarction risk using noninvasive analysis of patients living with coronary artery disease
* Corresponding Author; email: [email protected]1Department of Cell & Molecular Physiology, Stritch School o...
Deferoxamine Prevents Post-Stroke Memory Impairment in Female Diabetic Rats: Potential Links to Hemorrhagic Transformation and Ferroptosis
Deferoxamine Prevents Post-Stroke Memory Impairment in Female Diabetic Rats: Potential Links to Hemorrhagic Transformation and Ferroptosis
Diabetes increases the risk of post-stroke cognitive impairment (PSCI). Greater hemorrhagic transformation (HT) after stro...
Refining the Reproducibility of a Murine Model of Stress-Induced Reversible Cardiomyopathy
Refining the Reproducibility of a Murine Model of Stress-Induced Reversible Cardiomyopathy
Despite the many advantages of isoproterenol (ISO)-induced models of cardiomyopathy, the extant literature suggests that t...
Female Sex-Specific Considerations to Improve Rigor and Reproducibility in Cardiovascular Research
Female Sex-Specific Considerations to Improve Rigor and Reproducibility in Cardiovascular Research
Cardiovascular disease is the leading cause of death in women. Despite recognition of sex-specific differences in cardiova...
Sinus node dysfunction: current understanding and future directions
Sinus node dysfunction: current understanding and future directions
The sinoatrial node (SAN) is the primary pacemaker of the heart. Normal SAN function is crucial in maintaining proper card...
Automated quantification and statistical assessment of proliferating cardiomyocyte rates in embryonic hearts
Automated quantification and statistical assessment of proliferating cardiomyocyte rates in embryonic hearts
The use of digital image analysis and count regression models contributes to the reproducibility and rigor of histological...
A song of AAs and fire: divergent sex-dependent renal inflammatory mechanisms in hypertensive SLE mice
A song of AAs and fire: divergent sex-dependent renal inflammatory mechanisms in hypertensive SLE mice
Received 1 December 2022 ...
Regulation of cerebrovascular compliance compared with forearm vascular compliance in humans: a pharmacological study
Regulation of cerebrovascular compliance compared with forearm vascular compliance in humans: a pharmacological study
Vascular compliance represents an important determinant in the dynamics and regulation of blood flow through a vascular be...
Sex still matters in cardiovascular research
Sex still matters in cardiovascular research
Received 11 November 2022 ...
Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum
Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum
Pregnancy and lactation increase volume load on the heart. Defects in cardiac remodeling during pregnancy and postpartum c...
Sex as a biological variable in exercise prescription: A critical consideration in developing a road map for sex-related differences in cardiovascular research.
Sex as a biological variable in exercise prescription: A critical consideration in developing a road map for sex-related differences in cardiovascular research.
1Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States2Geriatric ...
Myocardial epigenetic modifications link chronic kidney disease to coronary microvascular disease
Myocardial epigenetic modifications link chronic kidney disease to coronary microvascular disease
* Corresponding Author; email: [email protected]1Walter Brendel Center of Experimental Medicine (WBex), University Clinic ...
Acute sedentary behavior and cardiovascular disease research: standardizing the methodological posture
Acute sedentary behavior and cardiovascular disease research: standardizing the methodological posture
Sedentary behavior has been identified as an independent predictor of future cardiovascular disease risk and all-cause mor...
Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure
Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure
During ischemic heart failure (IHF), cardiac muscle contraction is typically impaired while the molecular changes within t...
Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls
Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls
We examined cardiovascular and physical functioning outcomes in nonhospitalized patients with COVID-19, at a median of 6 m...
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