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An -deficient hypoperfusion model reveals Moyamoya-relevant neurovascular remodeling
An -deficient hypoperfusion model reveals Moyamoya-relevant neurovascular remodeling
Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by progressive stenosis of the terminal portion...
Characterizing pancreatic cancer-associated fibroblast heterogeneity in vascular microphysiological systems
Characterizing pancreatic cancer-associated fibroblast heterogeneity in vascular microphysiological systems
Pancreatic Ductal Adenocarcinoma (PDAC), one of the deadliest cancer types, is dominated by a tumor microenvironment (TME)...
Prevascularized grafts with spatially organized MSC spheroids to accelerate therapeutic angiogenesis in ischemic disease
Prevascularized grafts with spatially organized MSC spheroids to accelerate therapeutic angiogenesis in ischemic disease
Ischemic diseases, characterized by impaired blood flow and progressive tissue necrosis, remain a major challenge in regen...
Endothelial AGO1 deficiency reduces breast cancer burden in mice
Endothelial AGO1 deficiency reduces breast cancer burden in mice
Endothelial cells (ECs) are crucial in cancer development and progression, partly by regulating tumor angiogenesis and imm...
MCC links Wnt/PCP signaling to endothelial polarity and vascular remodeling
MCC links Wnt/PCP signaling to endothelial polarity and vascular remodeling
Vascular remodeling is crucial for establishing a functional vasculature and maintaining organ homeostasis. In the central...
controls developmental angiogenesis via ribosome biogenesis-dependent regulation of Notch signaling
controls developmental angiogenesis via ribosome biogenesis-dependent regulation of Notch signaling
The development of a functional vasculature is controlled by the coordination of various mechanisms. Key molecules and sig...
A possible microvascular vulnerability in carotid artery dissection: insights from nailfold capillaroscopy
A possible microvascular vulnerability in carotid artery dissection: insights from nailfold capillaroscopy
Competing interests The authors declare no competing intere...
Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer
Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer
Despite its established role in breast cancer treatment, Doxorubicin treatment remains subject to adaptive resistance mech...
Endothelial Notch1 drives multicellular remodelling during hyaloid vessel regression
Endothelial Notch1 drives multicellular remodelling during hyaloid vessel regression
Hyaloid vessel regression is essential for vitreous transparency and normal vision, yet how this transient vascular networ...
Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs
Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs
Vascular endothelial growth factor receptor-2 (VEGFR2) is a key target for regulating the endothelial cell lineage and ang...
Semi-automated quantification of total and avascular retinal area in the rat model of oxygen-induced retinopathy
Semi-automated quantification of total and avascular retinal area in the rat model of oxygen-induced retinopathy
Quantification of retinal and avascular areas in the rat oxygen induced retinopathy (OIR) model is traditionally performed...
Critical role of endothelial regulator of G protein signaling 5 in postnatal angiogenesis
Critical role of endothelial regulator of G protein signaling 5 in postnatal angiogenesis
Regulator of G protein signaling 5 (RGS5) modulates G-protein coupled receptor (GPCR) signaling and is markedly upregulate...
Functional definition of endothelial progenitors by PROCR and PDGFRA co-expression
Functional definition of endothelial progenitors by PROCR and PDGFRA co-expression
The functional and molecular definition of progenitors giving rise to blood vessel endothelium in vivo remains disputed. U...
3D co-culture model of tumor spheroid and endothelial cells unveils ccRCC aberrant vasculature and distinct sensitivity to targeted treatments
3D co-culture model of tumor spheroid and endothelial cells unveils ccRCC aberrant vasculature and distinct sensitivity to targeted treatments
Clear cell renal cell carcinoma (ccRCC), the most common renal cancer, is largely driven by von Hippel Lindau (VHL) protei...
Long-term angiogenic and thromboinflammatory signatures in post-COVID-19 syndrome
Long-term angiogenic and thromboinflammatory signatures in post-COVID-19 syndrome
Post-COVID-19 syndrome is a major long-term sequela of severe SARS-CoV-2 infection, potentially involving persistent angio...
Smad3 deficiency attenuates disease severity in a zebrafish model for Smad6-related aortic disease
Smad3 deficiency attenuates disease severity in a zebrafish model for Smad6-related aortic disease
Thoracic aortic dissection (TAD) associates with a high mortality rate. Treatment options are limited and mainly consist o...
Lysosomal channel TPC2 modulates microglia-endothelial signaling in choroidal angiogenesis
Lysosomal channel TPC2 modulates microglia-endothelial signaling in choroidal angiogenesis
Pathological choroidal neovascularization underlies vision loss in neovascular age-related macular degeneration (nAMD), ye...
A high-sensitivity TIE2–GRB2 BRET platform for functional and pharmacologic profiling of pathogenic variants associated with venous malformations
A high-sensitivity TIE2–GRB2 BRET platform for functional and pharmacologic profiling of pathogenic variants associated with venous malformations
TIE2 is an endothelial receptor tyrosine kinase (RTK) essential for vascular integrity, and constitutively active TIE2 mut...
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Role of endothelial PDGFB in arterio-venous malformations pathogenesis
Arterial-venous malformations (AVMs) are direct connections between arteries and veins without an intervening capillary be...
Circulating Von Willebrand factor: a consistent biomarker predicting in-hospital mortality across different waves of the COVID-19 pandemic
Circulating Von Willebrand factor: a consistent biomarker predicting in-hospital mortality across different waves of the COVID-19 pandemic
Paris Cité University, Innovative Therapies in Hemostasis, INSERM, 75006, Paris, FranceDavid M. Smadja, Aurélien Philippe,...
Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
The healing of calvarial bone defects is a pressing clinical problem that involves the dynamic interplay between angiogene...
Correction: The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells
Correction: The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells
The Fig. 3a of this article originally contained an incorrect picture showing “HDAC7/AKAP12 siRNA” condition at t = 0 h. I...
Notch ligands are biomarkers of anti-TNF response in RA patients
Notch ligands are biomarkers of anti-TNF response in RA patients
Notch and its ligands play a critical role in rheumatoid arthritis (RA) pathogenesis. Hence, studies were conducted to del...
Targeting the microenvironment in the treatment of arteriovenous malformations
Targeting the microenvironment in the treatment of arteriovenous malformations
Extracranial arteriovenous malformations (AVMs) are regarded as rare diseases and are prone to complications such as pain,...
Executive summary of the 14th HHT international scientific conference
Executive summary of the 14th HHT international scientific conference
Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder characterized by small, dilated clu...
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
FLT1/VEGFR1 negatively regulates VEGF-A signaling and is required for proper vessel morphogenesis during vascular developm...
2022 14th HHT International Scientific Conference Abstracts
2022 14th HHT International Scientific Conference Abstracts
Medical therapeuticsO1 Cure HHT research network: building the roadmap to cure HHTFriday C, MS1; Krock N1; Schaefer N1; Le...
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”
Kow CS, Ramachandram DS, Hasan SS (2022) The effect of higher-intensity dosing of anticoagulation on the clinical outcomes...
The modes of angiogenesis: an updated perspective
The modes of angiogenesis: an updated perspective
Following the process of vasculogenesis during development, angiogenesis generates new vascular structures through a varie...
Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
Correction: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
School of Medicine, Klinikum Rechts Der Isar, Department of Nephrology, Technical University of Munich, Ismaninger Str. 22...
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