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Docosahexaenoic Acid Levels and Omega-3 Index, but Not Eicosapentaenoic Acid Levels, Are Associated With Improved Cognition in Cognitively Healthy Subjects With Coronary Artery Disease
Francine K. Welty Correspondence to: Francine K. Welty, MD, PhD, Beth Israel Deaconess Medical Center, 99 Brookline Ave, R...
How Lymphatic Endothelial Cells Destabilize Regulatory T Cells
Klaus Ley Correspondence to: Klaus Ley, Medical College of Georgia at Augusta University, Georgia Immunology Center, Laney...
Broadening the Scope of Dyslipidemia Therapy by Targeting APOC3 and ANGPTL3 (Angiopoietin-Like Protein 3)
The positive relationship between increased levels of circulating triglycerides and cardiovascular events has been observe...
Multiomic Spatial Mapping of Myocardial Infarction and Implications for Personalized Therapy
Ischemic heart disease including myocardial infarction is still the leading cause of death worldwide. Although the surviva...
Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in Mice
BACKGROUND: When aortic cells are under stress, such as increased hemodynamic pressure, they adapt to the environment by m...
Maternal Inheritance of Familial Hypercholesterolemia Gene Mutation Predisposes to Coronary Atherosclerosis as Assessed by Calcium Score in Adulthood
Background: Animal studies have demonstrated that fetal exposure to high maternal cholesterol levels during pregnancy pred...
Proteomics Analysis of Genetic Liability of Abdominal Aortic Aneurysm Identifies Plasma Neogenin and Kit Ligand: The ARIC Study
BACKGROUND: Genome-wide association studies have reported 23 gene loci related to abdominal aortic aneurysm (AAA)—a potent...
Association Between Arterial Stiffness and New-Onset Heart Failure: The Kailuan Study
BACKGROUND: Arterial stiffness (AS) was associated with heart failure (HF) in previous studies based on specific populatio...
The Year of miR-223: How Platelets Can Kill Cardiomyocytes
"The Year of miR-223: How Platelets Can Kill Cardiomyocytes." Arteriosclerosis, Thrombosis, and Vascular Biology, , pp. –F...
Heparin Does Not Regulate Circulating Human PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) in a General Population
BACKGROUND: PCSK9 (proprotein convertase subtilisin-kexin type 9) chaperones the hepatic LDLR (low-density lipoprotein rec...
DNA-Dependent Protein Kinase Mediates YB-1 (Y-Box Binding Protein)-Induced Double Strand Break Repair
BACKGROUND: DNA-PK (DNA-dependent protein kinase) is a stress-activated serine/threonine kinase that plays a central role ...
Cardiovascular Disease and Thrombosis in HIV Infection
HIV infection has transitioned from an acute, fatal disease to a chronic one managed by antiretroviral therapy. Thus, the ...
Circulating Tumor Cells and Cancer-Associated Venous Thrombosis: A Missing Link
Nigel Mackman Correspondence to: Nigel Mackman, PhD, Department of Medicine, 116 Manning Drive, 8004B Mary Ellen Jones Bui...
Two Strikes and You Are Out: Long-Term Cardiovascular Consequences of the Additive Effects of Pregnancy and a Brief High-Cholesterol Diet
Jennifer J. McIntosh Correspondence to: Jennifer J. McIntosh, DO, Department of Obstetrics and Gynecology, 9200 West Wisco...
Beneficial Effects of Moderate Hepatic Activin A Expression on Metabolic Pathways, Inflammation, and Atherosclerosis
BACKGROUND: Atherosclerosis is an inflammatory vascular disease marked by hyperlipidemia and hematopoietic stem cell expan...
PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia
Background: Atherosclerosis is a medical urgency manifesting at the onset of hypercholesterolemia and is associated with a...
Association Between Serum Bilirubin, Lipid Levels, and Prevalence of Femoral and Carotid Atherosclerosis: A Population-Based Cross-Sectional Study
Background: Bilirubin may prevent lipid peroxidation and have important antiatherosclerotic effects. We determined associa...
Myeloid-Specific Deletion of Lipid Plpp3 (Phosphate Phosphatase 3) Increases Cardiac Inflammation After Myocardial Infarction
Ahmed Abdel-Latif Correspondence to: Ahmed Abdel-Latif, University of Michigan, Department of Medicine-Cardiology, 1500 E....
Neutrophils Protect Against Staphylococcus aureus Endocarditis Progression Independent of Extracellular Trap Release
Background: Infective endocarditis (IE) is characterized by an infected thrombus at the heart valves. How bacteria bypass ...
Promoting Lymphangiogenesis and Lymphatic Growth and Remodeling to Treat Cardiovascular and Metabolic Diseases
Lymphatic vessels are low-pressure, blind-ended tubular structures that play a crucial role in the maintenance of tissue f...
Differential Expression of Inflammarafts in Macrophage Foam Cells and in Nonfoamy Macrophages in Atherosclerotic Lesions
Background: Reprogramming of monocytes and macrophage manifests in hyperinflammatory responses and chronification of infla...
Genetic Testing for Hypertriglyceridemia in Academic Lipid Clinics: Implications for Precision Medicine—Brief Report
Genetic Testing for Hypertriglyceridemia in Academic Lipid Clinics: Implications for Precision Medicine—Brief Report
Background: Severe hypertriglyceridemia is often caused by variants in genes of triglyceride metabolism. These variants in...
Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification
Cardiovascular disease is the most common cause of death worldwide, especially beyond the age of 65 years, with the vast m...
Alterations to Sphingomyelin Metabolism Affect Hemostasis and Thrombosis
BACKGROUND: Our recent studies suggest that sphingomyelin levels in the plasma membrane influence TF (tissue factor) proco...
Repair of Limb Ischemia Is Dependent on Hematopoietic Stem Cell Specific-SHP-1 Regulation of TGF-β1
BACKGROUND: Hematopoietic stem cell (HSC) therapy has shown promise for tissue regeneration after ischemia. Therefore, the...
Lp-PLA2 (Lipoprotein-Associated Phospholipase A2) Deficiency Lowers Cholesterol Levels and Protects Against Atherosclerosis in Rabbits
Background: Elevated plasma Lp-PLA2 (lipoprotein-associated phospholipase A2) activity is closely associated with an incre...
Histopathological Features of Cancer-Associated Venous Thromboembolism: Presence of Intrathrombus Cancer Cells and Prothrombotic Factors
Background: Cancer-associated venous thromboembolism (VTE) is a critical complication in patients with cancer. However, th...
ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice
BACKGROUND: Diabetes is a major risk factor for peripheral arterial disease. Clinical and preclinical studies suggest an i...
2022 Jeffrey M. Hoeg Award Lecture: Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease
Chronologic age is the dominant risk factor for coronary artery disease but the features of aging promoting coronary arter...
Ex Vivo Modeling of the PC (Protein C) Pathway Using Endothelial Cells and Plasma: A Personalized Approach
Background: The endothelial cell–dependent PC (protein C) pathway is critically involved in the regulation of coagulation,...
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