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Deciphering the pharmacodynamic characteristics of acupuncture and neuromodulation therapies: A novel perspective from organoid platforms

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Research progress and prospect on the mechanisms of non-invasive neuromodulation therapy and acupuncture in treating cognitive impairment after traumatic brain injury

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Valproic acid: Mechanistic insights into neuronal actions, epigenetic modulation, and clinical risk

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Personalizing nutrition therapy in inflammatory bowel disease: Practical applications and review of the latest studies

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Orchestrating mitochondrial catastrophe: Mechanistic insights and therapeutic frontiers of cuproptosis in precision pharmacology

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Riluzole in neuroinflammation and neurodegeneration: Mechanistic insights and experimental validation

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Editorial: Central and peripheral nervous system

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Clinical Pharmacokinetics of Afatinib: A Systematic Review

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Acupuncture and non-invasive neuromodulation–induced neuro-endocrine-immune changes associated with the amelioration of depression-like behaviors: A systematic review of animal studies

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The neuro-metabolic epidemic and the CB1R paradox

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State-dependent neurotensin modulation in the brain: From network dynamics to pharmacological opportunity

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Alopecia areata: Mechanisms, targeted therapies, and translational challenges

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Methotrexate: Integrating molecular pharmacology, systems toxicology, and precision rescue strategies

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Chrono-immunotherapy in precision oncology: Circadian control of the tumor microenvironment and time-of-day optimization of immune checkpoint blockade

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Targeting the ischemic cascade: Review on approved and investigational stroke therapies

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Senotherapeutic strategies for ovarian aging: Mechanistic insights and translational perspectives

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Glymphatic dysfunction in neurodegeneration: From impaired clearance to mechanism-driven therapeutic innovation

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Systems pharmacology approaches to modeling immune training and tolerance

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Redefining remission targets in inflammatory bowel disease: the rise of ultrasound remission

Inflammatory bowel disease (IBD) – which includes Crohn’s disease (CD) and ulcerative colitis (UC) – is a chronic, progres...

Current Opinion In Pharmacology

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Acupuncture for Depression: Decoding Neuroimmune Crosstalk and Targeting Anti-Inflammatory Mechanisms

Depression is characterized by depressed mood and loss of interest in activities, associated with psychological and somati...

Current Opinion In Pharmacology

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Real-World Evidence Supporting Orphan Drugs Approvals for Rare Neuromuscular Disorders in the European Union and the United States: Review of Public Assessment Reports (2015–2025)

The possibility of generating and storing clinical data electronically is making significant progress in the study of orph...

Current Opinion In Pharmacology

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Electro-Microbial Interplay in the Gut-Brain Axis: An Emerging Paradigm for Gut Microbiota Modulation via Vagus Nerve Stimulation

Central nervous system (CNS) diseases encompass neurodegenerative disorders, cerebrovascular diseases, central nervous sys...

Current Opinion In Pharmacology

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From One-Size-Fits-All to Phenotype-Based Pharmacotherapy: How Far Are We in Obesity Management?

Obesity is a global health crisis, projected to affect over one billion adults by 2030. Lifestyle modification strategies—...

Current Opinion In Pharmacology

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Beyond TNF and IL-12/23: The Rise of IL-23 Inhibitors in IBD Management

The global incidence of inflammatory bowel disease (IBD) has risen significantly in the past decade, making it a growing h...

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Nutritional Composition of Diets for Inducing and Maintaining Remission in IBD: From Bedside to Plate

There is growing interest in the role of dietary therapies in the management of inflammatory bowel diseases (IBD), includi...

Current Opinion In Pharmacology

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Innovative pipeline therapeutics in IBD: anti-TL1A and bispecific antibodies

Available online 25 November 2025, 102596Author links open overlay panel, AbstractThere has been significant progress made...

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The Role of Plant-Derived Compounds in Anti-Obesity Drug Discovery: A Molecular Perspective

Available online 28 November 2025, 102597Author links open overlay panel, , , , , , , , , Graphical abstractDownload: Down...

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Modulating neuroinflammation through electroacupuncture: Mechanistic insights and pharmacological synergies

“Neuroinflammation refers to a regulated immune response within the central nervous system (CNS), triggered by diverse ins...

Current Opinion In Pharmacology

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Ivermectin and non-parasitic disorders: An update

Ivermectin, a broad-spectrum anti-parasitic agent, demonstrates potential therapeutic benefits in treating non-parasitic a...

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High-quality randomised controlled trials of acupuncture interventions for autism spectrum disorder in the last 10 years (2015–2024): A literature review

The efficacy of acupuncture as a nonpharmacological therapy for autism spectrum disorder (ASD) has been increasingly studi...

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