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Redefining remission targets in inflammatory bowel disease: the rise of ultrasound remission
Inflammatory bowel disease (IBD) – which includes Crohn’s disease (CD) and ulcerative colitis (UC) – is a chronic, progres...
Acupuncture for Depression: Decoding Neuroimmune Crosstalk and Targeting Anti-Inflammatory Mechanisms
Depression is characterized by depressed mood and loss of interest in activities, associated with psychological and somati...
Real-World Evidence Supporting Orphan Drugs Approvals for Rare Neuromuscular Disorders in the European Union and the United States: Review of Public Assessment Reports (2015–2025)
The possibility of generating and storing clinical data electronically is making significant progress in the study of orph...
Electro-Microbial Interplay in the Gut-Brain Axis: An Emerging Paradigm for Gut Microbiota Modulation via Vagus Nerve Stimulation
Central nervous system (CNS) diseases encompass neurodegenerative disorders, cerebrovascular diseases, central nervous sys...
From One-Size-Fits-All to Phenotype-Based Pharmacotherapy: How Far Are We in Obesity Management?
Obesity is a global health crisis, projected to affect over one billion adults by 2030. Lifestyle modification strategies—...
Beyond TNF and IL-12/23: The Rise of IL-23 Inhibitors in IBD Management
The global incidence of inflammatory bowel disease (IBD) has risen significantly in the past decade, making it a growing h...
Nutritional Composition of Diets for Inducing and Maintaining Remission in IBD: From Bedside to Plate
There is growing interest in the role of dietary therapies in the management of inflammatory bowel diseases (IBD), includi...
Innovative pipeline therapeutics in IBD: anti-TL1A and bispecific antibodies
Available online 25 November 2025, 102596Author links open overlay panel, AbstractThere has been significant progress made...
The Role of Plant-Derived Compounds in Anti-Obesity Drug Discovery: A Molecular Perspective
Available online 28 November 2025, 102597Author links open overlay panel, , , , , , , , , Graphical abstractDownload: Down...
Modulating neuroinflammation through electroacupuncture: Mechanistic insights and pharmacological synergies
“Neuroinflammation refers to a regulated immune response within the central nervous system (CNS), triggered by diverse ins...
Ivermectin and non-parasitic disorders: An update
Ivermectin, a broad-spectrum anti-parasitic agent, demonstrates potential therapeutic benefits in treating non-parasitic a...
High-quality randomised controlled trials of acupuncture interventions for autism spectrum disorder in the last 10 years (2015–2024): A literature review
The efficacy of acupuncture as a nonpharmacological therapy for autism spectrum disorder (ASD) has been increasingly studi...
Immune cell subtype contributions to doxorubicin cardiotoxicity–defining immune targets for translational interventions
Volume 85, December 2025, 102581Author links open overlay panel, , , Doxorubicin (DOX) remains a cornerstone in the treatm...
Advances in pain therapeutics: Targets, mechanisms, and translational frontiers
Zsuzsanna Helyes, she is an MD, PhD, professor of pharmacology at the Department of Pharmacology and Pharmacotherapy, Univ...
Shaping surgical decisions in IBD — Unveiling the power of intestinal ultrasound across the perioperative pathway
Inflammatory bowel diseases (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), are chronic, immune-medi...
Targeting the unmet needs in IBD: Emerging therapies beyond biologics and small molecules
Inflammatory Bowel Diseases (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC) are chronic, immune-mediate...
Revolutionizing UC monitoring: The emerging role of intestinal ultrasound
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with a heterogeneous clinical presentation, ranging ...
Revolutionizing Crohn's disease monitoring: The emerging role of intestinal ultrasound
Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) that imposes a lifelong burden on patients and healthca...
CRISPR-Cas9 in acute myeloid leukaemia: Current state-of-art and future perspectives
Recent advances in gene editing technologies have literally opened a new revolutionary avenue in precision medicine. Along...
Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer
Volume 81, April 2025, 102505Author links open overlay panel, Chromatin dynamics, involving reversible changes in chromati...
Strategies to enhance anti-leukemia immunotherapy
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Therapeutic Hurdles in Acute Myeloid Leukemia: Leukemic Stem Cells, Inflammation and Immune Dysfunction
Acute myeloid leukemia (AML) is a highly heterogeneous and aggressive hematological malignancy characterized by the arrest...
Novel approaches to CAR T cell target identification in acute myeloid leukemia
Available online 8 April 2025, 102524Author links open overlay panelGordon Victor Hoffmann 1, Adrian Gottschlich 1 2 3 4, ...
Balancing genome integrity and carcinogenesis: Insights into DNA damage response, repair pathways, and cancer therapies
Dr. Sagar Sengupta is cancer cell biologist. The focus of his research is on trying to understand the mechanisms of genome...
Lipids and lipid regulators in intraocular pressure homeostasis
Increased intraocular pressure is the strongest correlated modifiable risk factor for developing primary open-angle glauco...
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation
Volume 73, December 2023, 102415Author links open overlay panel, , Highlights•Preclinical to clinical translation for nove...
Interventional functional diagnostics in gastrointestinal endoscopy: Combining diagnostic and therapeutic tools in the endoscopy suite with the functional lumen imaging probe
Interventional functional diagnostics in gastrointestinal endoscopy: Combining diagnostic and therapeutic tools in the endoscopy suite with the functional lumen imaging probe
Volume 73, December 2023, 102414Author links open overlay panel, , AbstractWith technical progress of gastrointestinal fun...
The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2
The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2
Pathogens, including viruses, have evolved to use host-encoded proteins to infect, replicate, and persist in the host [1]....
Pharmacologic treatment of gastroparesis: What is (still) on the horizon?
Pharmacologic treatment of gastroparesis: What is (still) on the horizon?
Volume 72, October 2023, 102395Author links open overlay panel, AbstractGastroparesis is a neuromuscular disorder of the u...
Discerning conformational dynamics and binding kinetics of GPCRs by 19F NMR
Discerning conformational dynamics and binding kinetics of GPCRs by 19F NMR
Available online 21 August 2023, 102377Author links open overlay panel, Abstract19F NMR provides a way of monitoring confo...
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