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Efficacy and safety of compound Qingdai enema in rapidly alleviating inflammatory activity in ulcerative colitis: a prospective study
Aim of the StudyTo observe the efficacy and safety of CQE in rapidly alleviating inflammatory activity in UC.Materials and...
Global research trends and hotspots of exosome-mediated drug delivery across the blood-brain barrier: a bibliometric study from 2015 to 2025
BackgroundThe blood-brain barrier (BBB) is a major obstacle to targeted drug delivery for central nervous system (CNS) dis...
Comparative effects of combined omeprazole and dose-escalated striatin therapy versus monotherapy on VEGF, ITF, gastric ulcer area, epithelial thickness, and inflammatory response in rats with aspirin-induced gastric injury
IntroductionAspirin-induced gastritis results from reduced prostaglandin synthesis and increased oxidative stress, comprom...
Post-marketing safety of tarlatamab in small cell lung cancer based on FAERS and WHO-VigiAccess with SHAP-based interpretable machine learning analysis of immune-related adverse events
BackgroundTarlatamab is a DLL3-targeted bispecific T-cell engager approved for previously treated extensive-stage small ce...
HCN4 gain-of-function mutation increases intrinsic heart rate and limits maladaptive remodeling under pressure overload
IntroductionGain-of-function (GOF) mutations in the cardiac pacemaker channel HCN4 have been associated with inappropriate...
Exploring early intervention in psychosis (EIP) perspectives towards pharmacogenomics (PGx) implementation to support antipsychotic prescribing: a multi-method qualitative exploration
IntroductionPharmacogenomics (PGx) is an emerging medicines optimization tool that may support efficacy and safety relatin...
Correction: The potential of Lisosan G as a possible treatment for glaucoma
Correction on: Amato R, Rossino MG, Cammalleri M, Timperio AM, Fanelli G, Dal Monte M, Pucci L, Casini G. The Potential of...
The impact of garlic and its active metabolites on degenerative musculoskeletal diseases
With the accelerating global population aging, the incidence of degenerative musculoskeletal diseases (such as osteoarthri...
Inhibition of pathogenic tau signaling via blocking of the phosphatase-activating domain by novel small molecules
IntroductionTau pathology is a major feature of Alzheimer’s disease (AD) and multiple other adult-onset neurodegenerative ...
Mechanisms, prevention, and management of aminoglycoside-induced hearing loss in neonates and children: a translational review
ObjectiveAminoglycoside antibiotics remain essential for treating serious neonatal and pediatric infections, yet carry a w...
Correction: Reversal of anxiety-like depression induced by chronic corticosterone by crocin I and surface-enhanced Raman spectroscopy monitoring of plasma metabolites
Anxiety disorders and depression are complex disorders that often occur together.There are currently no widespread treatme...
SPP1 and MMP1 as key therapeutic targets of Jingfang Granule in idiopathic pulmonary fibrosis: integrated bioinformatics and machine learning analysis
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited therapeutic options. Th...
Comparative neuroprotective and exercise capacity effects of prophylactic intermittent fasting and probiotics in sleep-deprived rats: insights into anti-inflammatory marker modulation and CLOCK gene regulation
BackgroundProphylactic probiotics and intermittent fasting (IF) substantially modulate the neuropsychological functions an...
Thrombotic outcomes and mortality with roxadustat for anemia in chronic kidney disease: a systematic review and meta-analysis of randomized trials
BackgroundRoxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia in patients wit...
Targeting phosphofructokinase in cancer: integrating natural products for metabolic reprogramming and therapeutic innovation
The metabolism of cancer cells is reprogrammed toward aerobic glycolysis (the Warburg effect), which stimulates tumor grow...
Efficacy of immune-based combinations across treatment lines in advanced hepatocellular carcinoma: a systematic review and network meta-analysis
BackgroundWith the rapid introduction of immune checkpoint inhibitors (ICIs) for advanced hepatocellular carcinoma (HCC), ...
Post-marketing safety evaluation of anthracycline for acute myeloid leukemia treatment: a real-world pharmacovigilance analysis
BackgroundAnthracyclines are key for acute myeloid leukemia (AML) but carry serious side effects. This study identifies th...
Impact of oral bacterial lysates on asthma control and immune parameters in children: evidence from an updated systematic review and meta-analysis of randomized trials
BackgroundThe role of oral bacterial lysates (OBLs) as adjuvant immunomodulatory therapy in pediatric asthma requires clar...
In-vivo antidiarrheal activity of aqueous and hydroethanolic extracts of Anacardium occidentale and Khaya senegalensis used in Benin (West Africa) in a castor oil-induced diarrhea model traditionally
BackgroundThe management of diarrheal diseases involves the use of medicinal plants, particularly in developing countries,...
Potential therapeutic mechanisms of Draconis Resina in cardiovascular diseases-a narrative review
1 IntroductionCardiovascular disease, recognized as the leading cause of mortality threatening human health, is a focus of...
Editorial: Cellular and molecular mechanisms in metabolic disorders: role of inflammation and oxidative stress
Metabolic disorders, including diabetes, obesity, and chronic kidney disease (CKD), remain leading contributors to global ...
Histone deacetylases: the critical enzymes for microglial activation involved in neuropathic pain
1 IntroductionThe definition of neuropathic pain has been developed over the past 30 years. In 1994, International Associa...
World no-tobacco: effects of second-hand smoke (SHS) and vapors on the developing and adult brain
1 IntroductionPlease see Figure 1 for the Prisma statement. Figure 1. The number of records identified from the PubMed d...
Clinical implications of fracture severity risk with pioglitazone: a systematic review and meta-analysis of clinical randomized trials
1 IntroductionStroke survivors face a significantly elevated risk of falls and the associated risk of fractures (Batchelor...
Case report: Effectiveness of Janus kinase inhibitors in the management of isolated noninfectious uveitis: a case series
1 IntroductionUveitis refers to inflammation of the uvea, which includes the iris, ciliary body, and choroid; however, it ...
Targeting miRNA with flavonoids: unlocking novel pathways in cardiovascular disease management
1 IntroductionCardiovascular disease (CVD) encompasses a range of heart and blood vessel disorders that are the leading ca...
Adverse event profile of lomustine and temozolomide: a descriptive analysis from WHO-VigiAccess
IntroductionGlioma is the most prevalent primary intracranial tumor, accounting for approximately 30% of all brain and cen...
Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1
IntroductionOxaliplatin is a widely used first-line chemotherapy agent for many types of tumors, including colorectal carc...
Apigenin protects ischemic stroke by regulating intestinal microbiota homeostasis, regulates brain metabolic profile
1 IntroductionStroke is a leading cause of death and disability, affecting nearly 100 million people worldwide (Carcel et ...
Pharmacophore screening, molecular docking, and MD simulations for identification of VEGFR-2 and c-Met potential dual inhibitors
1 IntroductionCancer poses a significant challenge to society, public health, and global economies in the current century....
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