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Hesperidin delays cell cycle progression into the G0/G1 phase via suspension of MAPK signaling pathway in intrahepatic cholangiocarcinoma
Hesperidin delays cell cycle progression into the G0/G1 phase via suspension of MAPK signaling pathway in intrahepatic cholangiocarcinoma
Abstract Intrahepatic cholangiocarcinoma (iCCA) derived from epithelial cells of bile ducts is highly aggressive tumor. He...
Silencing of circCDC14A prevents cerebral ischemia‐reperfusion injury via miR‐23a‐3p/CXCL12 axis
Silencing of circCDC14A prevents cerebral ischemia‐reperfusion injury via miR‐23a‐3p/CXCL12 axis
Abstract Ischemic stroke is one of the main causes of death and disability. Circular RNAs (circRNAs) have received extensi...
Selenium and silver nanoparticles: A new approach for treatment of bacterial and viral hepatic infections via modulating oxidative stress and DNA fragmentation
Selenium and silver nanoparticles: A new approach for treatment of bacterial and viral hepatic infections via modulating oxidative stress and DNA fragmentation
Abstract Nanoparticles are recently playing a potential role in improving drug uptake and the treatment of diseases. A var...
CN‐3 increases TMZ sensitivity and induces ROS‐dependent apoptosis and autophagy in TMZ‐resistance glioblastoma
CN‐3 increases TMZ sensitivity and induces ROS‐dependent apoptosis and autophagy in TMZ‐resistance glioblastoma
Abstract Many glioma patients develop resistance to temozolomide (TMZ) treatment, resulting in reduced efficacy and surviv...
Efficacy of N‐acetyl‐ l‐cysteine against glyphosate induced oxidative stress and apoptosis in testicular germ cells preventing infertility
Efficacy of N‐acetyl‐ l‐cysteine against glyphosate induced oxidative stress and apoptosis in testicular germ cells preventing infertility
Abstract The present era's demand for continuous pesticides' use to increase the agriculture outcome, has caused ...
Investigating the protective role of metformin on lithium‐induced hypothyroidism
Investigating the protective role of metformin on lithium‐induced hypothyroidism
Abstract Induction of oxidative stress events has been shown to be associated with lithium (Li) hypothyroidism induction. ...
Effect of m6A methyltransferase METTL3 ‐mediated MALAT1/E2F1/AGR2 axis on adriamycin resistance in breast cancer
Effect of m6A methyltransferase METTL3 ‐mediated MALAT1/E2F1/AGR2 axis on adriamycin resistance in breast cancer
Abstract N6-methyladenosine (m6A) methyltransferase METTL3 has been implicated in carcinogenesis, which may be associated ...
Association of Type 1 diabetes with ulcerative colitis in BALB/c mice: Investigations on sex‐specific differences
Association of Type 1 diabetes with ulcerative colitis in BALB/c mice: Investigations on sex‐specific differences
Abstract Diabetes comorbidity in ulcerative colitis (UC) has relevant clinical and therapeutic implications. The link betw...
Imine resveratrol analogs (IRAs): The strong antioxidant that can protect lymphocytes from oxidative damage
Imine resveratrol analogs (IRAs): The strong antioxidant that can protect lymphocytes from oxidative damage
Abstract Imine resveratrol analogs (IRAs) are promising new agents that can have higher positive effects and, simultaneous...
The combination of dapagliflozin and statins ameliorates renal injury through attenuating the activation of inflammasome‐mediated autophagy in insulin‐resistant rats
The combination of dapagliflozin and statins ameliorates renal injury through attenuating the activation of inflammasome‐mediated autophagy in insulin‐resistant rats
Abstract Long-term use of a high-fat diet with high-fructose (HFF) intake could promote insulin resistance and induce lipi...
Possible protective effects of CO Q10 against vincristine‐induced peripheral neuropathy: Targeting oxidative stress, inflammation, and sarmoptosis
Possible protective effects of CO Q10 against vincristine‐induced peripheral neuropathy: Targeting oxidative stress, inflammation, and sarmoptosis
Abstract Vincristine is a chemotherapy drug that belongs to the vinca alkaloids group. It is used for treatment of hematol...
Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL‐7702 cells
Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL‐7702 cells
Abstract Capsaicin could suppress the proliferation of cancer cells and inhibit many biochemical pathways associated with ...
SOX4 induces drug resistance of colorectal cancer cells by downregulating CYLD through transcriptional activation of microRNA‐17
SOX4 induces drug resistance of colorectal cancer cells by downregulating CYLD through transcriptional activation of microRNA‐17
Abstract Exposure to high doses of anticancer drugs can induce the emergence of a subpopulation of weakly proliferative an...
Reversal of cisplatin resistance by neferine/isoliensinine and their combinatorial regimens with cisplatin‐induced apoptosis in cisplatin‐resistant colon cancer stem cells (CSCs)
Reversal of cisplatin resistance by neferine/isoliensinine and their combinatorial regimens with cisplatin‐induced apoptosis in cisplatin‐resistant colon cancer stem cells (CSCs)
Abstract Cisplatin chemotherapy to the colorectal cancer cells (CRCs) is accompanied by dose-limiting adverse effects alon...
Protective effect of astaxanthin on experimental ovarian damage in rats
Protective effect of astaxanthin on experimental ovarian damage in rats
Abstract This study aimed to investigate the protective effect of astaxanthin (AS) on 3-nitropropionic acid (3-NPA) induce...
Ginsenoside‐Rg1 attenuates sepsis‐induced cardiac dysfunction by modulating mitochondrial damage via the P2X7 receptor‐mediated Akt/GSK‐3β signaling pathway
Ginsenoside‐Rg1 attenuates sepsis‐induced cardiac dysfunction by modulating mitochondrial damage via the P2X7 receptor‐mediated Akt/GSK‐3β signaling pathway
Abstract Ginsenoside-Rg1 (G-Rg1), a saponin that is a primary component of ginseng, is effective against inflammatory dise...
Daidzein exerts neuroprotective activity against MPTP‐induced Parkinson's disease in experimental mice and lipopolysaccharide‐induced  BV2 microglial cells
Daidzein exerts neuroprotective activity against MPTP‐induced Parkinson's disease in experimental mice and lipopolysaccharide‐induced  BV2 microglial cells
Abstract Parkinson's disease (PD) ranks as the second most neurodegenerative disease characterized by loss of neurons, bra...
Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases
Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases
Abstract Chronic diseases are a serious health concern worldwide, especially in the elderly population. Most chronic disea...
Natural products against cisplatin‐induced male reproductive toxicity: A comprehensive review
Natural products against cisplatin‐induced male reproductive toxicity: A comprehensive review
Abstract Cisplatin is widely used as one of the most effective anticancer agents in the treatment of some neoplasms. Repro...
Biomimetic synthesis of silver nanoparticles for treatment of N‐Nitrosodiethylamine‐induced hepatotoxicity
Biomimetic synthesis of silver nanoparticles for treatment of N‐Nitrosodiethylamine‐induced hepatotoxicity
Abstract The development of bioengineered nanoparticles has attracted considerable universal attention in the field o...
β‐Caryophyllene inhibits Fas‐ receptor and caspase‐mediated apoptosis signaling pathway and endothelial dysfunction in experimental myocardial infarction
β‐Caryophyllene inhibits Fas‐ receptor and caspase‐mediated apoptosis signaling pathway and endothelial dysfunction in experimental myocardial infarction
Abstract We planned to appraise the effects of β-caryophyllene on Fas- receptor and caspase-mediated apoptosis signa...
Citronellal alleviates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and apoptosis via Na+/H+ exchanger‐1 inhibition
Citronellal alleviates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and apoptosis via Na+/H+ exchanger‐1 inhibition
Abstract The medical usage of Doxorubicin (DOX) as a chemotherapeutic agent is restricted owing to its cardiotoxic propert...
Novel amino acid Schiff base Zn(II) complexes as new therapeutic approaches in diabetes and Alzheimer's disease: Synthesis, characterization, biological evaluation, and molecular docking studies
Novel amino acid Schiff base Zn(II) complexes as new therapeutic approaches in diabetes and Alzheimer's disease: Synthesis, characterization, biological evaluation, and molecular docking studies
Abstract Schiff bases are compounds that have gained importance in the paint industry due to their colorful nature and in ...
Autophagy‐lysosome dysfunction is involved in gastric ischemia‑reperfusion injury by promoting microglial activation in the paraventricular nucleus
Autophagy‐lysosome dysfunction is involved in gastric ischemia‑reperfusion injury by promoting microglial activation in the paraventricular nucleus
Abstract The hypothalamic paraventricular nucleus (PVN) is a specific center in the brain that regulates gastric mucosal i...
Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress‐mediated pyroptosis
Effects of quercetin on apoptosis and extracellular matrix degradation of chondrocytes induced by oxidative stress‐mediated pyroptosis
Abstract Quercetin has been preliminarily proven to serve as a potential agent for the treatment of osteoarthritis (OA). H...
Caffeic acid phenethyl ester mitigates infertility: A crucial role of metalloproteinase and angiogenic factor in cadmium‐induced testicular damage
Caffeic acid phenethyl ester mitigates infertility: A crucial role of metalloproteinase and angiogenic factor in cadmium‐induced testicular damage
Abstract Cadmium (Cd) is expected to cause deleterious effects on most organs, especially on the male reproductive system....
Protective effects of 6‐gingerol on 6‐hydroxydopamine‐induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation
Protective effects of 6‐gingerol on 6‐hydroxydopamine‐induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation
Abstract Due to many therapeutic effects, Ginger (Zingiber officinale) is the most widely used spice around the world, inc...
Impact of FOXP1 rs2687201 genetic variant on the susceptibility to HCV‐related hepatocellular carcinoma in Egyptians
Impact of FOXP1 rs2687201 genetic variant on the susceptibility to HCV‐related hepatocellular carcinoma in Egyptians
Abstract Hepatocellular carcinoma (HCC) constitutes a challenging health problem in Egypt due to the high incidence of hep...
Lutein induces an inhibitory effect on the malignant progression of pancreatic adenocarcinoma by targeting BAG3/cholesterol homeostasis
Lutein induces an inhibitory effect on the malignant progression of pancreatic adenocarcinoma by targeting BAG3/cholesterol homeostasis
Abstract Pancreatic adenocarcinoma (PDAC) is a fatal malignancy and patients with PDAC are mostly diagnosed at advanced st...
Genetic variant in the 5ʹ untranslated region of endothelin1 (EDN1) gene in children with primary nephrotic syndrome
Genetic variant in the 5ʹ untranslated region of endothelin1 (EDN1) gene in children with primary nephrotic syndrome
Abstract Endothelin-1 plays a crucial role in the pathophysiology of nephrotic syndrome (NS) in children. The primary purp...
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