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Humans and Rodents: The Case of hOAT4 and mOat5 [Viewpoint]
Humans and Rodents: The Case of hOAT4 and mOat5 [Viewpoint]
The human organic anion transporter 4, hOAT4 (SLC22A11, solute carrier family 22 member 11) is expressed at the apical mem...
Characterization of Human Organic Anion Transporter 4 (hOAT4) and Mouse Oat5 (mOat5) As Functional Orthologs for Renal Anion Uptake and Efflux Transport [Metabolism, Transport, and Pharmacogenetics]
Characterization of Human Organic Anion Transporter 4 (hOAT4) and Mouse Oat5 (mOat5) As Functional Orthologs for Renal Anion Uptake and Efflux Transport [Metabolism, Transport, and Pharmacogenetics]
AbstractOrganic anions (OAs) are compounds including drugs or toxicants that are negatively charged at physiologic pH and ...
Precisely Providing Analgesia through Selectively Targeting the GABAA {alpha}2/{alpha}3 Subtypes [Viewpoint]
Precisely Providing Analgesia through Selectively Targeting the GABAA {alpha}2/{alpha}3 Subtypes [Viewpoint]
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter within the brain regulating neuronal excitability th...
Antinociceptive Effects of {alpha}2/{alpha}3-Subtype-Selective GABAA Receptor Positive Allosteric Modulators KRM-II-81 and NS16085 in Male Rats: Behavioral Specificity [Behavioral Pharmacology]
Antinociceptive Effects of {alpha}2/{alpha}3-Subtype-Selective GABAA Receptor Positive Allosteric Modulators KRM-II-81 and NS16085 in Male Rats: Behavioral Specificity [Behavioral Pharmacology]
AbstractRecent studies suggest that among the gamma-aminobutyric acid type A (GABAA)receptor subtype heterogeneity, α2/α3 ...
Understanding Cisplatin Pharmacokinetics and Toxicodynamics to Predict and Prevent Kidney Injury [Minireview]
Understanding Cisplatin Pharmacokinetics and Toxicodynamics to Predict and Prevent Kidney Injury [Minireview]
AbstractCisplatin is a common platinum-based chemotherapeutic that induces acute kidney injury (AKI) in about 30% of patie...
Molecular Mechanisms Underlying Amyloid Beta Peptide Mediated Upregulation of Vascular Cell Adhesion Molecule-1 in Alzheimer Disease [Cellular and Molecular]
Molecular Mechanisms Underlying Amyloid Beta Peptide Mediated Upregulation of Vascular Cell Adhesion Molecule-1 in Alzheimer Disease [Cellular and Molecular]
AbstractAmyloid β(Aβ) deposition and neurofibrillary tangles are widely considered the primary pathological hallmarks of f...
Dopamine D1-Like Receptor-Mediated Insurmountable Blockade of the Reinforcing Effects of Cocaine in Rats [Behavioral Pharmacology]
Dopamine D1-Like Receptor-Mediated Insurmountable Blockade of the Reinforcing Effects of Cocaine in Rats [Behavioral Pharmacology]
AbstractPrevious studies indicated differing effects of dopamine D1-like and D2-like receptor (D1R and D2R, respectively) ...
CH6824025, Potent and Selective Discoidin Domain Receptor 1 Inhibitor, Reduces Kidney Fibrosis in Unilateral Ureteral Obstruction Mice [Drug Discovery and Translational Medicine]
CH6824025, Potent and Selective Discoidin Domain Receptor 1 Inhibitor, Reduces Kidney Fibrosis in Unilateral Ureteral Obstruction Mice [Drug Discovery and Translational Medicine]
AbstractDiscoidin domain receptor 1 (DDR1) is a collagen receptor with tyrosine kinase activity, and its expression is enh...
Catalogue of Somatic Mutations in Cancer Database and Structural Modeling Analysis of CYP2D6 Mutations in Human Cancers [Drug Discovery and Translational Medicine]
Catalogue of Somatic Mutations in Cancer Database and Structural Modeling Analysis of CYP2D6 Mutations in Human Cancers [Drug Discovery and Translational Medicine]
AbstractSingle nucleotide polymorphisms (SNPs) in cytochrome P450 (CYP450) enzymes alter the metabolism of a variety of dr...
The Influence of the Estrous Cycle on Neuropeptide S Receptor-Mediated Behaviors [Neuropharmacology]
The Influence of the Estrous Cycle on Neuropeptide S Receptor-Mediated Behaviors [Neuropharmacology]
AbstractThe neuropeptide S receptor (NPSR) has been identified as a potential therapeutic target for anxiety and post-trau...
Is Overexpression of the Plasma Membrane Transporter (SLC29A4) a New Option to Stratify Patients with High-Risk Neuroblastoma for Treatment with 131I-mIBG? [Viewpoint]
Is Overexpression of the Plasma Membrane Transporter (SLC29A4) a New Option to Stratify Patients with High-Risk Neuroblastoma for Treatment with 131I-mIBG? [Viewpoint]
Neuroblastoma (NB) is a heterogenous disease with solid tumors in infants and young children originating from neural crest...
The Plasma Membrane Monoamine Transporter is Highly Expressed in Neuroblastoma and Functions as an mIBG Transporter [Metabolism, Transport, and Pharmacogenetics]
The Plasma Membrane Monoamine Transporter is Highly Expressed in Neuroblastoma and Functions as an mIBG Transporter [Metabolism, Transport, and Pharmacogenetics]
AbstractNeuroblastoma (NB) is a pediatric cancer with low survival rates in high-risk patients. 131I-mIBG has emerged as a...
Unlocking the Goldenseal Reveals the Complexities of Natural Product-Drug Interactions [Viewpoint]
Unlocking the Goldenseal Reveals the Complexities of Natural Product-Drug Interactions [Viewpoint]
Botanical natural products are a rich source of diverse phytochemicals that allow for the continued development of novel t...
An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations [Metabolism, Transport, and Pharmacogenetics]
An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations [Metabolism, Transport, and Pharmacogenetics]
AbstractThe natural product goldenseal is a clinical inhibitor of CYP3A activity, as evidenced by a 40%–60% increase in mi...
Role of Cannabinoid Signaling in Cardiovascular Function and Ischemic Injury [Minireview]
Role of Cannabinoid Signaling in Cardiovascular Function and Ischemic Injury [Minireview]
AbstractCardiovascular disease represents a leading cause of death, morbidity, and societal economic burden. The prevalenc...
Chidamide Induces Epstein-Barr Virus (EBV) Lytic Infection and Acts Synergistically with Tenofovir to Eliminate EBV-Positive Burkitt Lymphoma [Drug Discovery and Translational Medicine]
Chidamide Induces Epstein-Barr Virus (EBV) Lytic Infection and Acts Synergistically with Tenofovir to Eliminate EBV-Positive Burkitt Lymphoma [Drug Discovery and Translational Medicine]
1Blood Diseases Institute (L.X., M.Z., D.T., Z.L., T.L., Y.Z., S.Z., Y.M., D.Y., X.W., W.S.) and Key Laboratory of Bone Ma...
Serum Glucocorticoid-Regulated Kinase-1 in Ischemia-Reperfusion Injury: Blessing or Curse [Minireview]
Serum Glucocorticoid-Regulated Kinase-1 in Ischemia-Reperfusion Injury: Blessing or Curse [Minireview]
AbstractThe family of serum-glucocorticoid-regulated kinase (SGK) consists of three paralogs, SGK-1, SGK-2, and SGK-3, wit...
First-in-Human Phase 1 Randomized Trial with the Anti-CD40 Monoclonal Antibody KPL-404: Safety, Tolerability, Receptor Occupancy, and Suppression of T-Cell-Dependent Antibody Response [Inflammation, Immunopharmacology, and Asthma]
First-in-Human Phase 1 Randomized Trial with the Anti-CD40 Monoclonal Antibody KPL-404: Safety, Tolerability, Receptor Occupancy, and Suppression of T-Cell-Dependent Antibody Response [Inflammation, Immunopharmacology, and Asthma]
AbstractBlockade of the cluster of differentiation 40 (CD40)–CD40L interaction has potential for treating autoimmune disea...
Dimethyl Fumarate Ameliorated Cardiorenal Anemia Syndrome and Improved Overall Survival in Dahl/Salt-Sensitive Rats [Drug Discovery and Translational Medicine]
Dimethyl Fumarate Ameliorated Cardiorenal Anemia Syndrome and Improved Overall Survival in Dahl/Salt-Sensitive Rats [Drug Discovery and Translational Medicine]
IntroductionPatients with chronic kidney disease often develop cardiovascular disease and die before reaching end-stage re...
Biodistribution of Agmatine to Brain and Spinal Cord after Systemic Delivery [Neuropharmacology]
Biodistribution of Agmatine to Brain and Spinal Cord after Systemic Delivery [Neuropharmacology]
AbstractAgmatine, an endogenous polyamine, has been shown to reduce chronic pain behaviors in animal models and in patient...
Central Nervous System Distribution of Panobinostat in Preclinical Models to Guide Dosing for Pediatric Brain Tumors [Metabolism, Transport, and Pharmacogenetics]
Central Nervous System Distribution of Panobinostat in Preclinical Models to Guide Dosing for Pediatric Brain Tumors [Metabolism, Transport, and Pharmacogenetics]
AbstractAchieving adequate exposure of the free therapeutic agent at the target is a critical determinant of efficacious c...
Correction to "Could a Nebulized or Dry Powder Inhalation of a Dopamine D1R Agonist Be a Treatment of Idiopathic Pulmonary Fibrosis?" [Erratum]
Correction to "Could a Nebulized or Dry Powder Inhalation of a Dopamine D1R Agonist Be a Treatment of Idiopathic Pulmonary Fibrosis?" [Erratum]
In the above article, [Andresen B (2023) Could a Nebulized or Dry Powder Inhalation of a Dopamine D1R Agonist Be a Treatme...
A Novel Approach to Predicting Organic Anion Transporting Polypeptide Function in Human Hepatic Drug Disposition and Biliary Clearance [Viewpoint]
A Novel Approach to Predicting Organic Anion Transporting Polypeptide Function in Human Hepatic Drug Disposition and Biliary Clearance [Viewpoint]
The transport of drugs into and out of the liver plays a critical role in determining drug disposition and therapeutic eff...
Quantitative Prediction of OATP-Mediated Disposition and Biliary Clearance Using Human Liver Chimeric Mice [Drug Discovery and Translational Medicine]
Quantitative Prediction of OATP-Mediated Disposition and Biliary Clearance Using Human Liver Chimeric Mice [Drug Discovery and Translational Medicine]
AbstractDrug biliary clearance (CLbile) in vivo is among the most difficult pharmacokinetic parameters to predict accurate...
Hydrocodone, Oxycodone, and Morphine Metabolism and Drug-Drug Interactions [Minireview]
Hydrocodone, Oxycodone, and Morphine Metabolism and Drug-Drug Interactions [Minireview]
AbstractAwareness of drug interactions involving opioids is critical for patient treatment as they are common therapeutics...
The Anti-Inflammatory Action of Cannabigerol Accompanied by the Antioxidant Effect of 3-O-ethyl Ascorbic Acid in UVA-Irradiated Human Keratinocytes [Cellular and Molecular]
The Anti-Inflammatory Action of Cannabigerol Accompanied by the Antioxidant Effect of 3-O-ethyl Ascorbic Acid in UVA-Irradiated Human Keratinocytes [Cellular and Molecular]
AbstractExcessive daily exposure of human skin to natural UVA radiation leads to impaired redox homeostasis in epidermal k...
Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23 [Drug Discovery and Translational Medicine]
Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23 [Drug Discovery and Translational Medicine]
AbstractInterleukin (IL)-23 exists as a heterodimer consisting of p19 and p40 and is a key cytokine for promoting inflamma...
The Novel GlycoPEGylated FGF21 Analog Pegozafermin Activates Human FGF Receptors and Improves Metabolic and Liver Outcomes in Diabetic Monkeys and Healthy Human Volunteers [Drug Discovery and Translational Medicine]
The Novel GlycoPEGylated FGF21 Analog Pegozafermin Activates Human FGF Receptors and Improves Metabolic and Liver Outcomes in Diabetic Monkeys and Healthy Human Volunteers [Drug Discovery and Translational Medicine]
AbstractPegozafermin (also known as BIO89-100) is a glycoPEGylated analog of fibroblast growth factor 21 (FGF21) under dev...
Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice [Drug Discovery and Translational Medicine]
Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice [Drug Discovery and Translational Medicine]
AbstractPompe disease is a rare glycogen storage disorder caused by a deficiency in the lysosomal enzyme acid α-glucosidas...
Characterization of Selective M5 Acetylcholine Muscarinic Receptor Modulators on Dopamine Signaling in the Striatum [Neuropharmacology]
Characterization of Selective M5 Acetylcholine Muscarinic Receptor Modulators on Dopamine Signaling in the Striatum [Neuropharmacology]
AbstractThe type-5 muscarinic acetylcholine receptor (mAChR, M5) is almost exclusively expressed in dopamine (DA) neurons ...
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