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Rhynchophylline rewires DLAT lipoylation via conformational control to reverse mitochondrial bioenergetic collapse against dopaminergic neuronal injury

Acta Pharmaceutica Sinica B

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Nanobodies targeting SARS-CoV-2 variants

Acta Pharmaceutica Sinica B

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Targeting SIRT6 epigenetically restrains neutrophil hyperplasia and enhances chemotherapeutic efficacy

Acta Pharmaceutica Sinica B

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Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy

Acta Pharmaceutica Sinica B

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SNX3 exacerbates hepatic fibrosis by amplifying TGF-β1/Smad signaling pathway in hepatocyte-HSC fibrotic loop

Acta Pharmaceutica Sinica B

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Selenium nanozymes effectively treat rheumatoid arthritis by specifically activating selenoproteins to block oxidative damage and cGAS-STING signaling pathway

Acta Pharmaceutica Sinica B

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Xiangshao granules regulate the dopaminergic synapse pathway and improve menopausal anxiety in peri- and postmenopausal Chinese women: A multi-center, double-blind, randomized controlled trial

Acta Pharmaceutica Sinica B

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Gut microbiota-derived 5-HTP penetrates the host blood–brain barrier and ameliorates autism symptoms

Acta Pharmaceutica Sinica B

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The role of non-coding RNAs in regulating R-loop dynamics in cancer: Mechanisms and therapeutic implications

Acta Pharmaceutica Sinica B

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Emerging insights into PPARα’s role in lean metabolic dysfunction-associated steatotic liver disease: Implications for targeted therapies

Acta Pharmaceutica Sinica B

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Metrnl in mitigating radiation enteritis via label-retaining cells protection by modulating the c-KIT-WNT pathway

Acta Pharmaceutica Sinica B

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A novel small molecule inhibitor targeting KHSRP methylation suppresses colon cancer progression

Acta Pharmaceutica Sinica B

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Intelligent nano delivery systems: Classification, stimuli-responsive mechanisms, and therapeutic applications in criticalillnesses

Acta Pharmaceutica Sinica B

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Advances of oral micro- and nanomedicines for modulating intestinal barriers in the treatment of intestinal diseases

Acta Pharmaceutica Sinica B

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Telomere-associated non-malignant pulmonary diseases: Pathogenic mechanisms and therapeutic strategies

Acta Pharmaceutica Sinica B

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Lysosomal membrane damage repair and acidification impairment restoration triggered by smart lipid nanoparticles for Alzheimer’s disease treatment

Acta Pharmaceutica Sinica B

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Rationale of renewed efforts in developing MC4R modulators to treat metabolic disorders

Acta Pharmaceutica Sinica B

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Inhalable songorine-integrated lipid nanomedicine for targeted ARDS therapy via repairing endothelial barrier and inactivating NLRP3 inflammasome

Available online 4 November 2025Author links open overlay panel, , , , , , , , , , , AbstractAcute respiratory distress sy...

Acta Pharmaceutica Sinica B

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Cuproptosis-based nanomedicine in cancer metastasis synergistic therapy

Available online 5 November 2025Author links open overlay panel, , , , , , , , , , AbstractCancer metastasis is a critical...

Acta Pharmaceutica Sinica B

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Lipid-based nanosystems for atherosclerosis treatment: Evolving approaches and novel therapeutic strategies

Available online 5 November 2025Author links open overlay panel, , , , , , , , , , , AbstractAtherosclerosis, the leading ...

Acta Pharmaceutica Sinica B

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pH-Activatable engineered nanoparticle-based selective hexokinase 2 degrader provokes GSDME-dependent pyroptosis for cancer therapy

Available online 5 November 2025Author links open overlay panel, , , , , , , , , AbstractProteolysis targeting chimeras (P...

Acta Pharmaceutica Sinica B

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Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3

In our screening campaign for novel ferroptosis inhibitors, we identified that vitamin A (VA) and its metabolite all-trans...

Acta Pharmaceutica Sinica B

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A novel machine learning framework-based rapid screening of ionizable lipids in LNPs for highly-efficient mRNA expression

Available online 7 November 2025Author links open overlay panel, , , , , , , , , , , , , , , , , , AbstractIonizable lipid...

Acta Pharmaceutica Sinica B

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Antibody‒drug conjugates with DHODH inhibitor as novel payload class for cancer and SARS-CoV-2 infection therapies

Available online 12 November 2025Author links open overlay panel, , , , , , , , , , , , , AbstractDespite remarkable achie...

Acta Pharmaceutica Sinica B

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Carboxylated prodrug of capsaicin with enhanced peripheral nerve permeation mediated by monocarboxylate transporters for long-lasting local anesthesia

Available online 12 November 2025Author links open overlay panel, , , , , , , , , AbstractPerineurally injected nerve-bloc...

Acta Pharmaceutica Sinica B

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Engineered bacterial extracellular vesicles mediate pyroptosis to counteract m6A methylation-based immunosuppression after insufficient radiofrequency ablation of hepatocellular carcinoma

Available online 12 November 2025Author links open overlay panel, , , , , , , , , , , , , , , , AbstractInsufficient radio...

Acta Pharmaceutica Sinica B

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An immunostimulant nanomedicine enhances radioimmunotherapy by remodeling the tumor immunosuppressive landscape after radiotherapy

Available online 13 November 2025Author links open overlay panel, , , , , , , AbstractStudies have shown that radiotherapy...

Acta Pharmaceutica Sinica B

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