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Role of mGluR7 in Alzheimer’s disease: pathophysiological insights and therapeutic approaches
Role of mGluR7 in Alzheimer’s disease: pathophysiological insights and therapeutic approaches
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterised by oxidative stress, mitochondrial...
Targeting TREM-1 receptors with metformin and pravastatin modulate monosodium iodoacetate-induced osteoarthritis
Targeting TREM-1 receptors with metformin and pravastatin modulate monosodium iodoacetate-induced osteoarthritis
Osteoarthritis (OA), a degenerative joint condition, affects entire joints, including the tissues around it, causing pain,...
Chaperone-mediated autophagy, heat shock protein 70, and serotonin: novel targets of beta-hydroxybutyrate in HFFD/LPS-induced sporadic Alzheimer’s disease model
Chaperone-mediated autophagy, heat shock protein 70, and serotonin: novel targets of beta-hydroxybutyrate in HFFD/LPS-induced sporadic Alzheimer’s disease model
Sporadic Alzheimer’s disease (AD), which accounts for the majority of cases, is sturdily influenced by lifestyle fac...
Impact of NSAIDs corticosteroids DMARDs biologics and their comparisons with natural products in C-reactive proteins (CRP) linked cardiovascular disorders
Impact of NSAIDs corticosteroids DMARDs biologics and their comparisons with natural products in C-reactive proteins (CRP) linked cardiovascular disorders
An important part of the pathophysiology of atherosclerosis is the involvement of inflammatory processes, which mediate va...
Anti-arthritic potential and mechanistic insights of methanol extract of Engl. in complete Freund’s adjuvant-induced rats
Anti-arthritic potential and mechanistic insights of methanol extract of Engl. in complete Freund’s adjuvant-induced rats
This study determined the phytochemical profile and in vivo anti-arthritic potential and mechanistic effects of MeOH extra...
Empagliflozin and memantine combination ameliorates cognitive impairment in scopolamine + heavy metal mixture-induced Alzheimer’s disease in rats: role of AMPK/mTOR, BDNF, BACE-1, neuroinflammation, and oxidative stress
Empagliflozin and memantine combination ameliorates cognitive impairment in scopolamine + heavy metal mixture-induced Alzheimer’s disease in rats: role of AMPK/mTOR, BDNF, BACE-1, neuroinflammation, and oxidative stress
One of the major consequences of diabetes mellitus that has gained attention due to its rising incidence is cognitive impa...
Bioactive potential of with detailed insight into anti-inflammatory activity through in vitro, in vivo evaluations and network pharmacology
Bioactive potential of with detailed insight into anti-inflammatory activity through in vitro, in vivo evaluations and network pharmacology
This study evaluated Tripleurospermum inodorum extract for cytotoxic, anti-inflammatory, antioxidant, antimicrobial, and a...
Amelioration of pain and adjuvant-induced arthritis by syringic acid via modulation of behavioral parameters and inflammatory mediators i.e. TNF-α, Interleukins, MCP-1, NF-kB and COX-2
Amelioration of pain and adjuvant-induced arthritis by syringic acid via modulation of behavioral parameters and inflammatory mediators i.e. TNF-α, Interleukins, MCP-1, NF-kB and COX-2
Syringic acid with reported anti-inflammatory attribute was investigated in the present study to assess its anti-arthritic...
A comprehensive review of the impact of natural products in preventing drug-induced ototoxicity
A comprehensive review of the impact of natural products in preventing drug-induced ototoxicity
Ototoxicity, the property of certain drugs to cause hearing loss, is a significant concern in medical treatments, particul...
Exploring the potential of seed extract-loaded microemulsion hydrogel in the DNCB-induced atopic dermatitis model
Exploring the potential of seed extract-loaded microemulsion hydrogel in the DNCB-induced atopic dermatitis model
Moringa oleifera n-hexane (MO n-Hex) seed extract contains phytoconstituents such as behenic acid, quercetin, and kaempfer...
From receptor to response: dissecting the TLR4 pathway in diabetic neuropathy
From receptor to response: dissecting the TLR4 pathway in diabetic neuropathy
Diabetic neuropathy (DNP) is a common complication of diabetes that has a significant impact on the patient’s qualit...
Dapagliflozin targets the crosstalk between apoptosis, autophagy, and Hedgehog signaling pathways through AMPK activation in the adjuvant-induced arthritic rat model
Dapagliflozin targets the crosstalk between apoptosis, autophagy, and Hedgehog signaling pathways through AMPK activation in the adjuvant-induced arthritic rat model
Rheumatoid arthritis is a long-term autoimmune disorder, causes joint capsule, cartilage, and bone damage. Dapagliflozin, ...
Decoding the role of glucocorticoid-regulated kinase 1 in Alzheimer's disease: a promising path toward novel therapeutic strategies
Decoding the role of glucocorticoid-regulated kinase 1 in Alzheimer's disease: a promising path toward novel therapeutic strategies
Serum glucocorticoid-regulated kinase 1 (SGK1) is a ubiquitous serine and threonine kinase and has been implicated in many...
Inhibition of TRPM3 channels in the medial prefrontal cortex mitigates OCD symptoms following traumatic brain injury
Inhibition of TRPM3 channels in the medial prefrontal cortex mitigates OCD symptoms following traumatic brain injury
Although tumor necrosis factor-alpha (TNF-α) plays an important role in the development of obsessive–compulsive...
PDE4 inhibitors in psoriasis therapy: current insights and future directions
PDE4 inhibitors in psoriasis therapy: current insights and future directions
The chronic autoimmune disease known as psoriasis creates major life-quality problems for affected patients. The disease e...
Clinical study evaluating the efficacy and safety of Cilostazol as an adjuvant therapy to methotrexate on patients with rheumatoid arthritis
Clinical study evaluating the efficacy and safety of Cilostazol as an adjuvant therapy to methotrexate on patients with rheumatoid arthritis
This study aims to assess the safety as well as effectiveness of Cilostazol as a complementary therapy to methotrexate amo...
Calprotectin inhibition attenuates silica-induced lung fibrosis
Calprotectin inhibition attenuates silica-induced lung fibrosis
Respirable silica exposure adversely affects lung tissue immunopathology, triggering oxidative bursts in macrophages and n...
A pharmaco-metabolomics study of , and in acute allergic dermatitis
A pharmaco-metabolomics study of , and in acute allergic dermatitis
Acute allergic contact dermatitis is an inflammatory skin condition characterized by swollen, itchy lesions. This study ai...
Full-spectrum extract enhances gut-peripheral organ integrity after experimental ischemic stroke
Full-spectrum extract enhances gut-peripheral organ integrity after experimental ischemic stroke
This study aims to investigate the impact of full-spectrum Cannabis sativa extract (FSC) treatment on gut and peripheral o...
Natural agents as wound-healing promoters
Natural agents as wound-healing promoters
The management of acute and chronic wounds resulting from diverse injuries poses a significant challenge to clinical pract...
Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2
Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2
Medicinal plants play a pivotal role in the prevention of chronic non-communicable diseases including arthritis. Despite t...
Using aspirin to prevent and treat cancer
Using aspirin to prevent and treat cancer
This review will discuss evidence that aspirin possesses anticancer activity. Long-term observational retrospective studie...
Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane
Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane
Natural products are recognized as potential analgesics since many of them are part of modern medicine to relieve pain wit...
Resveratrol protects against Schistosoma mansoni-induced liver fibrosis by targeting the Sirt-1/NF-κB axis
Resveratrol protects against Schistosoma mansoni-induced liver fibrosis by targeting the Sirt-1/NF-κB axis
Hepatic schistosomiasis is a prevalent form of chronic liver disease that drastically affects human health. Nevertheless, ...
Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19
Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19
Recently, a global outbreak of COVID-19 has rapidly spread to various national regions. As the number of COVID-19 patients...
Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues
Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues
Pulmonary fibrosis is a devastating disorder distinguished by redundant inflammation and matrix accumulation in the lung i...
Liensinine reduces acute lung injury brought on by lipopolysaccharide by inhibiting the activation of the NF-κB signaling pathway through modification of the Src/TRAF6/TAK1 axis
Liensinine reduces acute lung injury brought on by lipopolysaccharide by inhibiting the activation of the NF-κB signaling pathway through modification of the Src/TRAF6/TAK1 axis
ALI is characterized by macrophage-driven inflammation, causing severe lung damage. Currently, there are limited therapeut...
L-Carnitine augments probenecid anti-inflammatory effect in monoiodoacetate-induced knee osteoarthritis in rats: involvement of miRNA-373/P2X7/NLRP3/NF-κB milieu
L-Carnitine augments probenecid anti-inflammatory effect in monoiodoacetate-induced knee osteoarthritis in rats: involvement of miRNA-373/P2X7/NLRP3/NF-κB milieu
Osteoarthritis (OA) is a degenerative joint disease, whereas the underlying molecular trails involved in its pathogenesis ...
Synthesis of novel nonsteroidal anti-inflammatory galloyl β-sitosterol-loaded lignin-capped Ag-based drug
Synthesis of novel nonsteroidal anti-inflammatory galloyl β-sitosterol-loaded lignin-capped Ag-based drug
Biocompatible anti-inflammatory lignin-capped Ag (LCAg) nanoparticles (NPs) were synthesized for the delivery of galloyl &...
Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis
Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis
Pyroptosis is a novel type of proinflammatory programmed cell death that is associated with inflammation, immunity, and ca...
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