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Histological Features of the Nasal Passage in Juvenile Japanese White Rabbits
Histological Features of the Nasal Passage in Juvenile Japanese White Rabbits
Rabbits are sometimes used for intranasal toxicology studies. We investigated the postnatal development of the nasal passa...
Obituary: Dr Gordon Charles Hard (1931-2021)
Obituary: Dr Gordon Charles Hard (1931-2021)
Dr Gordon Hard, of Tairua, New Zealand, a preeminent international toxicology thought leader and international consultant ...
Whole Slide Imaging (WSI) in Toxicologic Pathology
Whole Slide Imaging (WSI) in Toxicologic Pathology
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Safety and Performance Evaluation of Su2ura Approximation, a New Suturing Device, in Pigs
Safety and Performance Evaluation of Su2ura Approximation, a New Suturing Device, in Pigs
One of the challenging aspects of minimal invasive surgery (MIS) is intracorporal suturing, which can be significantly tim...
Proteomic Analysis of Subchronic Furan Exposure in the Liver of Male Fischer F344 Rats
Proteomic Analysis of Subchronic Furan Exposure in the Liver of Male Fischer F344 Rats
Furan is a volatile compound formed during the thermal processing of foods. Chronic exposure has been shown to cause chola...
Opinion on the Optimal Histologic Evaluation of the Bone Marrow in Nonclinical Toxicity Studies
Opinion on the Optimal Histologic Evaluation of the Bone Marrow in Nonclinical Toxicity Studies
Identification of bone marrow toxicity is an important issue in drug development and toxicologic pathologists play a criti...
Histology Atlas of the Developing Mouse Placenta
Histology Atlas of the Developing Mouse Placenta
The use of the mouse as a model organism is common in translational research. This mouse–human similarity holds true for p...
Implementation and Practice of Deep Learning-Based Instance Segmentation Algorithm for Quantification of Hepatic Fibrosis at Whole Slide Level in Sprague-Dawley Rats
Implementation and Practice of Deep Learning-Based Instance Segmentation Algorithm for Quantification of Hepatic Fibrosis at Whole Slide Level in Sprague-Dawley Rats
Exponential development in artificial intelligence or deep learning technology has resulted in more trials to systematical...
Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat
Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat
Aneurysms of the ascending aorta, unrelated to xenobiotic administration, are described in 5 rats and 2 mice in nonclinica...
Carcinogenicity Evaluation of Baclofen in TgrasH2 Mice
Carcinogenicity Evaluation of Baclofen in TgrasH2 Mice
Baclofen is a γ-aminobutyric acid-B receptor agonist used for control of spastic muscle activity and as a treatment for al...
Granulocytosis, a Paraneoplastic Syndrome Associated With Non-Glandular Squamous Cell Carcinomas (NGSCC) in the Tg.rasH2 Studies
Granulocytosis, a Paraneoplastic Syndrome Associated With Non-Glandular Squamous Cell Carcinomas (NGSCC) in the Tg.rasH2 Studies
Non-glandular squamous cell carcinoma (NGSCC) is an extremely rare tumor in Tg.raH2 mice. There have been 5 NGSCC in 1615 ...
Spontaneous Primary Pleural Mesothelioma in Fischer 344 (F344) and Other Rat Strains: A Retrospective Review
Spontaneous Primary Pleural Mesothelioma in Fischer 344 (F344) and Other Rat Strains: A Retrospective Review
Spontaneous primary pleural mesotheliomas in Fischer 344 (F344) or other rat strains have rarely been reported. The object...
Scientific and Regulatory Policy Committee Points to Consider: Biological Sample Retention From Nonclinical Toxicity Studies
Scientific and Regulatory Policy Committee Points to Consider: Biological Sample Retention From Nonclinical Toxicity Studies
Samples of biologic specimens and their derivatives (eg, wet tissues, paraffin-embedded tissue blocks, histology slides, f...
Scientific and Regulatory Policy Committee Points to Consider: Fixation, Trimming, and Sectioning of Nonrodent Eyes and Ocular Tissues for Examination in Ocular and General Toxicity Studies
Scientific and Regulatory Policy Committee Points to Consider: Fixation, Trimming, and Sectioning of Nonrodent Eyes and Ocular Tissues for Examination in Ocular and General Toxicity Studies
A Working Group of the Society of Toxicologic Pathology’s Scientific and Regulatory Policy Committee conducted a technical...
Artificial Intelligence in Toxicological Pathology: Quantitative Evaluation of Compound-Induced Follicular Cell Hypertrophy in Rat Thyroid Gland Using Deep Learning Models
Artificial Intelligence in Toxicological Pathology: Quantitative Evaluation of Compound-Induced Follicular Cell Hypertrophy in Rat Thyroid Gland Using Deep Learning Models
Digital pathology has recently been more broadly deployed, fueling artificial intelligence (AI) application development an...
Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vectors
Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vectors
Sequencing of the human genome and numerous advances in molecular techniques have launched the era of genetic medicine. In...
Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling
Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling
Kidney biopsies are used sparingly to diagnose kidney injury in the clinic. Here we have conducted a small exploratory stu...
Prenatal Evaluations: A Prologue to Postnatal Pathology Interpretations
Prenatal Evaluations: A Prologue to Postnatal Pathology Interpretations
Animal models are commonly used to investigate the developmental basis of human birth defects. Such models may be used for...
Symmetric Dimethylarginine Is a Sensitive Biomarker of Glomerular Injury in Rats
Symmetric Dimethylarginine Is a Sensitive Biomarker of Glomerular Injury in Rats
Glomerular filtration rate is the gold-standard method for assessment of renal function but is rarely performed in routine...
Proceedings of the 2021 National Toxicology Program Satellite Symposium
Proceedings of the 2021 National Toxicology Program Satellite Symposium
The 2021 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri,” was the 20th annive...
Neuropathology Evaluation in Juvenile Toxicity Studies in Rodents: Comparison of Developmental Neurotoxicity Studies for Chemicals With Juvenile Animal Studies for Pediatric Pharmaceuticals
Neuropathology Evaluation in Juvenile Toxicity Studies in Rodents: Comparison of Developmental Neurotoxicity Studies for Chemicals With Juvenile Animal Studies for Pediatric Pharmaceuticals
The developmental neuropathology examination in juvenile toxicity studies depends on the nature of the product candidate, ...
Regulatory Perspectives on Juvenile Animal Toxicologic Pathology
Regulatory Perspectives on Juvenile Animal Toxicologic Pathology
The Society of Toxicologic Pathology’s Annual Virtual Symposium (2021) included a session on "Regulatory Perspectives...
Postnatal Hepatobiliary and Gastrointestinal Systems Development and Impact on ADME
Postnatal Hepatobiliary and Gastrointestinal Systems Development and Impact on ADME
Toxicity can result from variable target organ sensitivity and exposure based on postnatal development. Changes in the gas...
Comparative Milestones in Rodent and Human Postnatal Central Nervous System Development
Comparative Milestones in Rodent and Human Postnatal Central Nervous System Development
Within the substantially different time scales characterizing human and rodent brain development, key developmental proces...
Characterization of the Nonendocrine Cell Populations in Human Embryonic Stem Cell–Derived (hESC) Islet-Like Clusters Posttransplantation
Characterization of the Nonendocrine Cell Populations in Human Embryonic Stem Cell–Derived (hESC) Islet-Like Clusters Posttransplantation
Islet-like clusters derived from human embryonic stem cells (hESC) hold the potential to cure type 1 diabetes mellitus. Di...
Phthalate Toxicity in Rats and Its Relation to Testicular Dysgenesis Syndrome in Humans
Phthalate Toxicity in Rats and Its Relation to Testicular Dysgenesis Syndrome in Humans
This work describes the relevance of toxicology studies of environmental chemicals, with a focus on phthalates, for a hypo...
Toxicity and Local Tolerance of COVID- eVax, a Plasmid DNA Vaccine for SARS-CoV-2, Delivered by Electroporation
Toxicity and Local Tolerance of COVID- eVax, a Plasmid DNA Vaccine for SARS-CoV-2, Delivered by Electroporation
COVID-19 is a rapidly spreading disease, posing a huge hazard to global health. The plasmid vaccine pTK1A-TPA-SpikeA (name...
Opinion on Maintaining In-House GLP Status for Toxicologic Pathology in Pharmaceutical and (Agro)Chemical Development
Opinion on Maintaining In-House GLP Status for Toxicologic Pathology in Pharmaceutical and (Agro)Chemical Development
Many pharmaceutical companies have recently elected to stop maintaining good laboratory practices (GLP) status of their R&...
Brief Synopsis: “Instruction Manual for Juvenile Clinical Pathology”
Brief Synopsis: “Instruction Manual for Juvenile Clinical Pathology”
This symposium synopsis summarizes key points discussed related to clinical pathology data interpretation for reproduction...
Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the Göttingen Minipig
Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the Göttingen Minipig
The use of minipigs as an alternative nonclinical species has increased in the last 20 years. The Society of Toxicologic P...
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