SCI Abstract

search
+
DNA G-quadruplexes: Structural and functional insights
It has been over a century since Ivar Bang first noted the unusual self-aggregating property of the guanylic acid-forming ...
Recent advances in understanding the molecular mechanisms of SLX4 recruitment in the replication stress response
Although DNA replication is tightly regulated, various impediments can stall DNA replication forks. SLX4 is a scaffold pro...
Fueling for the finish line: Control of human telomerase activity by nucleotide metabolism
Telomeres are comprised of repetitive sequences at the ends of chromosomes that promote genome stability [1], [2]. Telomer...
How DNA secondary structures drive replication fork instability
DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic feature...
Cutting edge perspectives in genome maintenance XII
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Stepwise DNA damage and repair mechanisms at replication forks in response to topoisomerase I inhibition
DNA replication ensures the precise duplication of the genome during the S phase. The replisome, a complex molecular machi...
Base excision repair and homologous recombination are required for prevention of a chronic DNA damage response in Saccharomyces cerevisiae
The chromosomes within eukaryotic cells can be chemically altered through exposure to exogenous chemical and physical DNA ...
A tale of two mechanisms: Clarification of the pathway for MBD4 catalyzed glycosidic bond cleavage using MD and QM/MM calculations
DNA methylation to yield 5-methylcytosine (5mC) in CpG motifs plays a vital role in epigenetic regulation. However, deamin...
Genetic analysis reveals a timing-dependent functional interplay between Polζ and Polη in translesion DNA synthesis upon UV damage
Translesion DNA synthesis (TLS) plays a crucial role in restarting stalled replication at damaged templates. This process ...
Efficient activity of uracil DNA glycosylase (UNG2) in proliferating cells requires binding to proliferating cell nuclear antigen (PCNA) and replication protein A (RPA)
The compounds pemetrexed and 5-fluorodeoxyuridine (FdU) are widely used for cancer therapies and disrupt cell proliferatio...
Polymerase theta: Genome protection through regulated deployment
DNA Polymerase theta (Polθ, gene name POLQ) is the central enzyme of theta-mediated end-joining (TMEJ), an intrinsically m...
Obituary: Francis Fabre (1940–2024): Yeast geneticist that contributed to our understanding of the control of homologous recombination
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Transport of DNA repair proteins to the cell nucleus by the classical nuclear importin pathway – a structural overview
DNA is a highly reactive molecule and is susceptible to damage caused by both endogenous and exogenous factors, including ...
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis
The 9–1–1 complex, comprising the Rad9, Hus1 and Rad1 proteins, is believed to operate as a component of a DNA damage chec...
Stained DNA Dot Detection (SD3): An automated tool for quantifying fluorescent features along single stretched DNA molecules
The main information in DNA is its four-letter sequence that builds up the genetic information and that is traditionally r...
Temporal and spatial dynamics of DNA double-strand break repair centers
Double-strand breaks (DSBs) are the most severe type of DNA damage, as unrepaired DSBs can lead to genomic instability, ma...
Identification of a novel pathogenic XPC:c.2420 + 1 G>C variant in a patient with xeroderma pigmentosum
Xeroderma Pigmentosum (XP) is a rare, inherited autosomal recessive genetic disorder that affects both males and females e...
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae
Polyubiquitylation of the replication factor PCNA activates the replicative bypass of DNA lesions via an error-free pathwa...
The replication stress response: Mechanisms and functions
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Werner helicase as a therapeutic target in mismatch repair deficient colorectal cancer
Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of cancer-related deat...
Building an integrated view of R-loops, transcription, and chromatin
R-loops, formed through DNA-RNA hybridization during transcription, are intrinsically linked to both transcription and chr...
Role of HSP40 proteins in genome maintenance, insulin signaling and cancer therapy
Heat shock proteins (HSPs), also called molecular chaperones, are classified into several families according to their mole...
Modulation of OGG1 enzymatic activities by small molecules, promising tools and current challenges
Oxidative DNA damage, resulting from endogenous cellular processes and external sources plays a significant role in mutage...
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy
Advanced epithelial ovarian cancer of the high-grade serous subtype (HGSOC) remains a significant clinical challenge due t...
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome
The CRISPR/Cas9 technology is a powerful and versatile tool to disrupt genes’ functions by introducing sequence-specific D...
Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases
The joining of DNA single- and double-strand breaks (SSB and DSB) is essential for maintaining genome stability and integr...
Targeting DNA damage sensors for cancer therapy
DNA damage occurs from both endogenous and exogenous sources and DNA damaging agents are a mainstay in cancer therapeutics...
Targeting base excision repair in precision oncology
Targeting the DNA damage response (DDR) is a key strategy in cancer therapy, leveraging tumour-specific weaknesses in DNA ...
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]
Volume 149, May 2025, 103835Author links open overlay panelAmanda K. McCullough a b, Irina G. Minko a, Michael M. Luzadder...
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment
Discovered in the 1990s, the BRCA1 and BRCA2 genes are now recognized as quintessential tumor suppressor genes, whose muta...
Load More
format_indent_increase