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Neuron irradiation of Caenorhabditis elegans by protons triggers base excision repair pathway with limited effect on behaviour

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Tissue-specific CTG•CAG expansion rate and disease severity are modified by DNA repair genes expression levels in myotonic dystrophy type 1 patients

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PARP1 safeguards nascent DNA from SMUG1-dependent processing of incorporated 5-hydroxymethyl-2′-deoxyuridine

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NEK3 promotes cancer resistance through facilitating CtIP-mediated DNA repair

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Molecular mechanisms of DNA damage recognition and chromatin dynamics regulating mammalian nucleotide excision repair

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Sex and base excision repair as key susceptibility factors for alkylation-induced mutations, toxicity and hepatic cancer

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Characterization of a Ku-binding motif in the C-terminal region of RAG2

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Navigating nuclear space: How Rad51 filaments promote long-range homology search during homologous recombination – Lessons from budding yeast

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From oxidative damage to actionable lesion: Telomeric 8-oxoGuanine and OGG1 modulation in aging and disease

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DNA G-quadruplexes: Structural and functional insights

It has been over a century since Ivar Bang first noted the unusual self-aggregating property of the guanylic acid-forming ...

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Recent advances in understanding the molecular mechanisms of SLX4 recruitment in the replication stress response

Although DNA replication is tightly regulated, various impediments can stall DNA replication forks. SLX4 is a scaffold pro...

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Fueling for the finish line: Control of human telomerase activity by nucleotide metabolism

Telomeres are comprised of repetitive sequences at the ends of chromosomes that promote genome stability [1], [2]. Telomer...

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How DNA secondary structures drive replication fork instability

DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic feature...

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Cutting edge perspectives in genome maintenance XII

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Stepwise DNA damage and repair mechanisms at replication forks in response to topoisomerase I inhibition

DNA replication ensures the precise duplication of the genome during the S phase. The replisome, a complex molecular machi...

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Base excision repair and homologous recombination are required for prevention of a chronic DNA damage response in Saccharomyces cerevisiae

The chromosomes within eukaryotic cells can be chemically altered through exposure to exogenous chemical and physical DNA ...

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A tale of two mechanisms: Clarification of the pathway for MBD4 catalyzed glycosidic bond cleavage using MD and QM/MM calculations

DNA methylation to yield 5-methylcytosine (5mC) in CpG motifs plays a vital role in epigenetic regulation. However, deamin...

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Genetic analysis reveals a timing-dependent functional interplay between Polζ and Polη in translesion DNA synthesis upon UV damage

Translesion DNA synthesis (TLS) plays a crucial role in restarting stalled replication at damaged templates. This process ...

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Efficient activity of uracil DNA glycosylase (UNG2) in proliferating cells requires binding to proliferating cell nuclear antigen (PCNA) and replication protein A (RPA)

The compounds pemetrexed and 5-fluorodeoxyuridine (FdU) are widely used for cancer therapies and disrupt cell proliferatio...

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Polymerase theta: Genome protection through regulated deployment

DNA Polymerase theta (Polθ, gene name POLQ) is the central enzyme of theta-mediated end-joining (TMEJ), an intrinsically m...

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Obituary: Francis Fabre (1940–2024): Yeast geneticist that contributed to our understanding of the control of homologous recombination

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Transport of DNA repair proteins to the cell nucleus by the classical nuclear importin pathway – a structural overview

DNA is a highly reactive molecule and is susceptible to damage caused by both endogenous and exogenous factors, including ...

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The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis

The 9–1–1 complex, comprising the Rad9, Hus1 and Rad1 proteins, is believed to operate as a component of a DNA damage chec...

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Stained DNA Dot Detection (SD3): An automated tool for quantifying fluorescent features along single stretched DNA molecules

The main information in DNA is its four-letter sequence that builds up the genetic information and that is traditionally r...

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Temporal and spatial dynamics of DNA double-strand break repair centers

Double-strand breaks (DSBs) are the most severe type of DNA damage, as unrepaired DSBs can lead to genomic instability, ma...

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Identification of a novel pathogenic XPC:c.2420 + 1 G>C variant in a patient with xeroderma pigmentosum

Xeroderma Pigmentosum (XP) is a rare, inherited autosomal recessive genetic disorder that affects both males and females e...

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Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae

Polyubiquitylation of the replication factor PCNA activates the replicative bypass of DNA lesions via an error-free pathwa...

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The replication stress response: Mechanisms and functions

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Werner helicase as a therapeutic target in mismatch repair deficient colorectal cancer

Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of cancer-related deat...

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Building an integrated view of R-loops, transcription, and chromatin

R-loops, formed through DNA-RNA hybridization during transcription, are intrinsically linked to both transcription and chr...

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