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Identification and validation of adenylate uridylate (AU)-rich element (ARE)-related biomarkers in the process of treating lung cancer mice with Wenyang Hualiu Tang through bulk RNA sequencing and animal model
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Surfactant protein D regulates Notch activity for secretory cell repair and regeneration to prevent post-acute pancreatitis diabetes
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Integrated single-cell RNA sequencing and multi-database analysis reveal THBS2 promotes high glucose-induced mesangial cell oxidative stress and fibrosis in diabetic nephropathy
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Identification of MORC2 via bioinformatics and machine learning reveals its transcriptional activation by PAX2 in NSCLC malignancy
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
ABL1-STAT3-NLRP3 axis attenuates pyroptosis and alleviates diabetic retinopathy
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Molecular targets and mechanisms of resveratrol in alleviating arrhythmia based on network pharmacology and bioinformatics
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Estrogen attenuates colonic mucinous adenocarcinoma growth in a rat model by inhibiting proliferation and promoting apoptosis
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Oxidative stress gene signature associated with vitiligo: A multi-algorithm machine learning and Mendelian randomization validation
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Metagenomics-guided cloning, expression, and characterization of thermotolerant multifunctional cellulase from Rehai Hot Spring
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Analysis of drug resistance, virulence phenotype, and genetic sequences in microevolutionary strains of Pseudomonas aeruginosa MPAO1
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Optimization of one-step enzymatic hydrolysis conditions for two large brown algae and analysis of the antioxidant activity of the hydrolysis products
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Exploration of OLFM4 as a biomarker for infantile pneumonia and underlying mechanisms via bioinformatics, machine learning algorithms, and LPS-induced models
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
IGF2BP3 promotes diabetic retinopathy development by enhancing SEMA3G mRNA stability
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Circulating exosomal miRNA signatures as potential biomarkers and therapeutic targets in biliary colic
BackgroundBiliary colic (BC), characterized by intermittent pain due to gallstone-related bile duct obstruction, remains p...
Tianma granules: Bridging traditional medicine and modern science to combat colorectal cancer via ferroptosis
BackgroundThis study aims to investigate the ferroptosis-inducing effects of Tianma Granules (TMGs) in colorectal cancer a...
Chufeng Yisun Decoction treats dry eye syndrome by inhibiting the PI3K/Akt pathway
BackgroundDry eye disease seriously affects people’s work and life. Chufeng Yisun Decoction is a traditional Chinese medic...
Transcriptomic and metabolomic profiling reveals key mechanisms of alkaline stress tolerance in rice
BackgroundAlkaline stress severely restricts rice growth and yield by disrupting ion balance, nutrient uptake, and oxidati...
Whole-genome analysis and biosynthetic gene cluster profiling of Stenotrophomonas sp. ASucR1 isolated from Sof Umer Cave, Ethiopia
Volume 78, November 2025, Pages 46-52Author links open overlay panel, , , , AbstractBackgroundSof Umer Cave is a unique ha...
ALYREF promotes malignant behaviors and inhibits ferroptosis in colon cancer cells by stabilizing PCSK9 mRNA
BackgroundColon cancer is a prevalent malignancy causing significant global morbidity and mortality. The RNA methyltransfe...
Qualitative phytochemical analysis, thin-layer chromatographic profiling, and antimicrobial potential of banana cultivars
Volume 78, November 2025, Pages 64-75Author links open overlay panel, , , , AbstractBackgroundBanana plants possess numero...
Mapping the genomic position of xylanase genes on Bacillus safensis FB03 and optimizing the xylanase fermentation medium by Box-Behnken Design from an unconventional carbon source
BackgroundThe ability of Bacillus safensis to synthesize xylanase and other industrially important enzymes utilizing ligno...
METTL16 promotes osteosarcoma progression by inducing m6A methylation of the UBE3A and Notch signaling pathway
BackgroundN6-methyladenosine (m6A) methylation plays a key role in osteosarcoma (OS) progression. This study aimed to eluc...
Kaixin San in treating vascular dementia via regulating the Bcl-2/Beclin-1/LC3A/B signaling pathway via animal experiments and network pharmacology analysis
Volume 78, November 2025, Pages 96-109Author links open overlay panel, , , , , , , , , AbstractBackgroundKaixin San (KXS),...
Biogenic synthesis of silver nanoparticles using cell-free extracts of thermotolerant bacteria: Antioxidant and antibacterial properties
BackgroundEco-friendly synthesis of silver nanoparticles (AgNPs) using biological systems offers a sustainable alternative...
Obituary for James D. Watson (1928-2025)
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Can broad bean (Vicia faba) and white lupin (Lupinus albus) flours serve as carbon sources to support probiotic growth?
BackgroundThere is growing interest in identifying substrates that support the growth of probiotics in foods. Pulses are a...
Anoikis and m6A related lncRNAs analysis to identify prognostic indicators in liver hepatocellular carcinoma
BackgroundIn cancer the process of anoikis is intimately associated with the emergence and progression. N6-methyladenosine...
HRMS-based profiling of metabolites, metal ions content and in-vitro cholinesterase inhibitory activities of Sonchus wightianus DC plant parts
BackgroundSonchus wightianus DC is native to South Asia and traditionally been known for its wide range application for th...
Metabolites of native actinomycetes from Sof Umer cave reveal potent antimicrobial activity against selected pathogens in mice infection models
BackgroundActinomycetes are gram-positive bacteria that belong to the actinobacterial species. They are a prolific source ...
ANKRD1 knockdown attenuates doxorubicin-induced dilated cardiomyopathy by regulating mitochondrial dysfunction and oxidative stress through activation of the AMPK/AKT/mTOR pathway
BackgroundDoxorubicin (DOX), a widely used chemotherapeutic agent, causes severe cardiotoxicity that frequently progresses...
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