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SerpinB2 promotes the proliferation of glioma cells by regulating the cell cycle through the Wnt/β-catenin signaling pathway
All the data of this study are available from the corresponding author upon reasonable request.The RNA-seq data generated ...
Strategic intercropping with mulberry (Morus alba L.) predictably modulates rhizosphere microbiome assembly and enriches pathways for secondary metabolite production
Volume 117, Issue 6, November 2025, 111129Author links open overlay panel, , , , , , , , Highlights•Mulberry intercropping...
Integrative microbiome-metabolomics identifies Pseudomonas as a potential pathogenic factor in endometriosis
Endometriosis (EMS) is a chronic disease characterized by unclear etiology, influenced by various genetic and environmenta...
Phenotypical, phytohormone and transcriptomic analysis revealed the mechanism of exogenous salicylic acid promoting alfalfa(Medicago sativa L.)germination under freezing stress
Freezing stress (FS), especially during germination, severely impacts the growth, development, productivity, and distribut...
High-fat diet promotes kidney lipid droplet deposition contributing to the pathogenesis of obesity-related glomerulopathy in mice through gut microbial metabolism
BackgroundObesity-related glomerulopathy (ORG) is a kidney disorder associated with obesity, where dysbiosis of the gut mi...
Metabolic heterogeneity in adipose resident immunocytes and its link to type 2 diabetes via response to catabolism defects
Adipose resident immune cells are vital contributors to adipose dysfunction in metabolic diseases. While current research ...
Neutrophil extracellular trap-related signature predicts the prognosis and immunotherapy outcome of lung adenocarcinoma
Volume 117, Issue 6, November 2025, 111147Author links open overlay panel, , , , , , , Highlights•Based on the NETs score,...
Regulation of alternative splicing of retinol metabolism in lipid abnormality of PCOS liver by Cyp4a32 and Hsd17b6
Liver lipid disorders are common in polycystic ovary syndrome (PCOS) patients. A DHEA-induced PCOS mouse model exhibited e...
Whole genome sequencing of Tilletia laevis, the fungal pathogen causing common bunt
Tilletia laevis is a fungal pathogen that causes the severe wheat disease known as common bunt, which is widespread in whe...
Construction of a genome-wide linkage map and QTL mapping for growth and hypoxia tolerance traits in Chinese longsnout catfish (Leiocassis longirostris)
The Chinese longsnout catfish (Leiocassis longirostris) is an important freshwater aquaculture species, and the selective ...
Combined short- and long-read sequencing reveals the important regulators and alternative splicing events associated with the thermo-sensitive flowering retardation of rice Tartary buckwheat
Heat stress has deleterious effects on flowering and yield of Tartary buckwheat. In this study, we compared the transcript...
Unveiling the role of integrated stress response in pterygium: EGLN3, HSPA8, and NDRG1 as novel biomarkers and therapeutic targets
PurposePterygium was a common progressive ocular disease with unclear pathogenesis. The aim of this study was to identify ...
Identification of cross-talk pathways and PANoptosis-related genes in periodontitis and atherosclerosis by bioinformatics analysis and machine learning
Background and objectivesPeriodontitis(PD) is a chronic inflammatory disease that poses a serious threat to oral health an...
Computational methods for the analysis of long-read RNA-seq data
Advancements in the accuracy of long-read sequencing technologies and bioinformatic approaches have broadened the applicat...
HvPR1: A dual-role architect in balancing grain weight and hardness in barley
Grain size critically determines both yield and quality in crops. This study systematically investigated two distinct qing...
Guiding eQTL mapping and genomic prediction of gene expression in three pig breeds with tissue-specific epigenetic annotations from early development
Raw sequence data supporting the findings of this study are available at the FAANG data portal (https://data.faang.org), w...
Divergent miRNA-mRNA networks contribute to tissue-specific lipid homeostasis in triploid rainbow trout skeletal muscle during high-lipid diet challenge
Rainbow trout (Oncorhynchus mykiss) is one of the most widely farmed salmonid species globally. To investigate the mechani...
Transcriptome profile analysis of miRNA and mRNA in chicken embryo gonad sex differentiation
Despite the integrative function of miRNAs and genes in chicken embryonic gonadal sex differentiation, their roles remain ...
Upregulation of CENPM facilitates glioma progression via PI3K/AKT signaling pathway
Glioma, one of the most common types of primary brain tumors, presents considerable challenges due to its poor prognosis. ...
Single-cell transcriptomic analysis reveals metabolic reprogramming and tumor microenvironment remodeling in aldosterone-producing adenoma
Aldosterone-producing adenoma (APA) is a significant cause of primary aldosteronism, however, its cellular heterogeneity r...
Comprehensive expression genome-wide association study of long non-coding RNAs in four porcine tissues
BackgroundLong non-coding RNAs (lncRNAs), a type of non-coding RNA molecules, are known to play critical regulatory roles ...
Identification of blacklist regions in cattle and pig genomes
Cattle and pigs are important farm animals and biomedical models for studying human development and diseases. Accurate ann...
Gap-free genome assembly and comparative analysis reveal the evolution and lignin degradation mechanisms of Cylindrobasidium torrendii
The Physalacriaceae family comprises numerous saprophytic edible and medicinal fungi with significant ecological and econo...
Integrated analysis of single-cell and bulk RNA sequencing identifies APOC1 as a biomarker and therapeutic target for G0/G1 cell cycle arrest in cholangiocarcinoma
Cholangiocarcinoma is characterized by its high malignancy, frequent recurrence and insensitivity to conventional radiothe...
Genomic insights and phylogenetics of the mitochondrial genome of Cryptocarya
The tropical genus Cryptocarya is known for its valuable timber and the constituents in these trees show potential for med...
METTL14 facilitates the process of sexual reversal via m6A RNA methylation in Pelodiscus sinensis
The Chinese soft-shelled turtle (Pelodiscus sinensis, P. sinensis) demonstrates noteworthy sexual dimorphism, where the ma...
Integrated analysis of lipid metabolism and differentially expressed genes reveal seed oil accumulation in field muskmelon
Field muskmelon (Cucumis melo L. var. agrestis Naud.), a novel oil crop, contains a high amount of lipids in seeds. Howeve...
Deep sequencing of Korean Jindo dog reveals evolutionary trajectory of coat color variations
The inherent diversity of canines is closely intertwined with the unique color patterns of each dog population. These vari...
Transcriptome and metabolome reveal the mechanism of neuroendocrine regulation in ovarian development of broiler breeders
The long-term selection for meat has led to the poor egg production efficiency in broiler. In this study, we analyzed the ...
Transcriptome analysis reveals that the injection of mesenchymal stem cells remodels extracellular matrix and complement components of the brain through PI3K/AKT/FOXO1 signaling pathway in a neuroinflammation mouse model
Author links open overlay panel, , , , , , , Highlights•The brains of mice that received injections of LPS and MSCs were s...
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