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A PIVOT towards single-cell functional genetic screening in plants
A PIVOT towards single-cell functional genetic screening in plants
We developed PIVOT, a single-cell screening platform for functional characterization of plant genes. PIVOT enables deliver...
Newcomer anti-IL-33 makes strides in COPD
Newcomer anti-IL-33 makes strides in COPD
AstraZeneca’s IL-33 antibody tozorakimab targets two distinct signaling pathways engaged in COPD: inflammation and e...
Circling back to RNA vaccines
While circRNA is often framed as a more stable, longer-lasting alternative to linear mRNA, its real-world advantages remai...
Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models
Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models
Although immunotherapy has benefited a subset of persons with cancer, its broader efficacy remains limited, primarily beca...
Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery
Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery
Predicting T cell receptor (TCR) specificity on the basis of sequence is challenging because TCRs of similar sequence can ...
Guide DNA — not RNA — expands the CRISPR toolkit
Guide DNA — not RNA — expands the CRISPR toolkit
Cas12 nucleases can use guide DNA instead of guide RNA, which switches their targets from DNA to RNA.
DNA-guided CRISPR–Cas12 for cellular RNA targeting
DNA-guided CRISPR–Cas12 for cellular RNA targeting
Here, we present ΨDNA, a DNA-based guide that enables RNA targeting by Cas12 nucleases, overcoming the traditional re...
Widespread DNA off-targeting confounds RNA chromatin occupancy studies
Widespread DNA off-targeting confounds RNA chromatin occupancy studies
Several high-throughput sequencing methods have been used to study the genome-wide chromatin occupancy of long noncoding R...
Starving tumors with fat
Starving tumors with fat
Adipocytes can be isolated, genetically manipulated, and then reimplanted. In this study, these properties were leveraged ...
Sound healing and beyond
Ultrasound neurotechnologies are moving quickly into clinical trials in a wide variety of applications, and initiatives to...
Implantation of engineered adipocytes suppresses tumor progression in cancer models
Implantation of engineered adipocytes suppresses tumor progression in cancer models
Tumors exhibit an increased ability to obtain and metabolize nutrients. Here, we implant engineered adipocytes that outcom...
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing
Here we report a method, smol-seq (small-molecule sequencing), using structure-switching aptamers (SSAs) and DNA sequencin...
SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci
SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci
Engineering T cell specificity and function at multiple loci can generate more effective cellular therapies, but current m...
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids
The value of lipid nanoparticles (LNPs) for delivery of messenger RNA (mRNA) was demonstrated by the coronavirus disease 2...
Gains in early-onset dementia with progranulin open new paths for drug discovery
Gains in early-onset dementia with progranulin open new paths for drug discovery
The first clinical results in patients with a genetic form of frontotemporal dementia (FTD) show that enhancing progranuli...
Precise RNA targeting with CRISPR–Cas13d
Precise RNA targeting with CRISPR–Cas13d
The possibility of collateral RNA degradation poses a concern for transcriptome perturbations and therapeutic applications...
A monomeric StayGold fluorescent protein
A monomeric StayGold fluorescent protein
StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite fav...
From AI to the Y chromosome (and everything in between)
Nature Biotechnology editors pick their favorite research articles from 2023.
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s annual survey highlights academic start ups that are, among other things, correcting misfolde...
The world’s first CRISPR therapy is approved: who will receive it?
The go-ahead for Vertex’s gene editing therapy in sickle cell disease and β-thalassemia is a historic milestone, but this ...
Tracing the fate of AAV vectors in the body
Tracing the fate of AAV vectors in the body
A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.
DNA nanodevices map intracellular ions
DNA nanodevices map intracellular ions
Two DNA nanodevices, RatiNa and pHlicker, provide precise mapping of sodium levels in acidic organelles and potassium acti...
Top ten news stories in 2023
Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashin...
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from huma...
Spatial methods for microbiome–host interactions
Spatial methods for microbiome–host interactions
Spatial transcriptomics offers a glimpse of how microbiomes interact with their hosts.
Spatial host–microbiome sequencing reveals niches in the mouse gut
Spatial host–microbiome sequencing reveals niches in the mouse gut
Mucosal and barrier tissues, such as the gut, lung or skin, are composed of a complex network of cells and microbes formin...
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
The interactions of microorganisms among themselves and with their multicellular host take place at the microscale, formin...
Modeling human trunk development
Modeling human trunk development
A model of the embryonic human trunk attains a more mature developmental stage than previous models.
Antibiotic nanoparticles boost antitumor immunity
Antibiotic nanoparticles boost antitumor immunity
Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T ce...
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are implicated in diverse psychiatric and...
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