SCI Abstract

search
+
Correction: Targeted suppression of tumor growth by CREPT promoter-driven diphtheria toxin fragment A
State Key Laboratory of Membrane Biology, School of Basic Medical Sciences, Tsinghua Medicine, Tsinghua University, Beijin...
Pleiotropic mechanisms of cancer-associated fibroblast-mediated resistance in hepatocellular carcinoma: emerging therapeutic vulnerabilities and targeting strategies
Pleiotropic mechanisms of cancer-associated fibroblast-mediated resistance in hepatocellular carcinoma: emerging therapeutic vulnerabilities and targeting strategies
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death around the world, with therapy resista...
Clathrin-associated SCYL2 contributes to the activation of PI3K/AKT signaling and tumorigenesis through PTEN phosphorylation in adult T-cell leukemia/lymphoma
Clathrin-associated SCYL2 contributes to the activation of PI3K/AKT signaling and tumorigenesis through PTEN phosphorylation in adult T-cell leukemia/lymphoma
Inactivation of PTEN by post-translational modifications causes aberrant amplification of the PI3K/AKT signaling pathway i...
MSCs delivering LIGHT prime immune response against CAFs to harness antigen loss variants
MSCs delivering LIGHT prime immune response against CAFs to harness antigen loss variants
The tumor niche promotes immune tolerance, enabling malignant cells to evade surveillance. Mesenchymal stem cells (MSCs) h...
The FOSB-IGFBP5-IGF-1 axis: a novel regulatory pathway that suppresses prostate cancer growth
The FOSB-IGFBP5-IGF-1 axis: a novel regulatory pathway that suppresses prostate cancer growth
While the functions of activator protein-1 (AP-1) family transcription factors in prostate cancer (PCa) have been well res...
Perspective of smart nanocapsule swallowable laser-guided for integrated sensing and crispr-mediated cancer gene editing
Perspective of smart nanocapsule swallowable laser-guided for integrated sensing and crispr-mediated cancer gene editing
Current therapeutic techniques for cancer often lack specificity. They also cause systemic toxicity and lack genetic contr...
COL3A1 promotes gastric cancer progression by activating PI3K/AKT signaling
COL3A1 promotes gastric cancer progression by activating PI3K/AKT signaling
COL3A1 plays an oncogenic role in several types of cancer; however, the function of COL3A1 in gastric cancer (GC) remains ...
HAUS1-mediated activation of CDK4 transcription enhances proliferation, invasion and migration in hepatocellular carcinoma
HAUS1-mediated activation of CDK4 transcription enhances proliferation, invasion and migration in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is distinguished by aggressive proliferation, invasion, and migration, with its underlying ...
Combined downregulation of TGF-β1 and GRP78 is responsible for overcoming acquired sorafenib resistance, which is initiated by rewiring the cell surface CD44-GRP78-IGF-1R signaling circuit
Combined downregulation of TGF-β1 and GRP78 is responsible for overcoming acquired sorafenib resistance, which is initiated by rewiring the cell surface CD44-GRP78-IGF-1R signaling circuit
Previously, we showed that the downregulation of both HSP27 and TGF-β1 decreased the survival of various tumor types....
Correction: Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolism-based strategy to impair glioblastoma (GBM)
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 ...
DR1 activates histone gene expression to maintain pancreatic cancer cell survival through the ATAC complex
DR1 activates histone gene expression to maintain pancreatic cancer cell survival through the ATAC complex
Pancreatic ductal adenocarcinoma (PDAC) is the most malignant cancer and is characterized by short survival and limited tr...
Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity through the PSGL-1-VISTA axis
Targeting mTORC2 in lung squamous cell carcinoma improves anti-tumor immunity through the PSGL-1-VISTA axis
Targeted therapies have improved survival for lung adenocarcinoma patients. However, similar advances are lacking for lung...
APOE deficiency triggers anti-tumour activity of macrophages in liver cancer
APOE deficiency triggers anti-tumour activity of macrophages in liver cancer
Macrophage infiltration correlates with poor prognosis in patients with liver cancer and resistance to immunotherapy. Howe...
RUNX1A isoform is overexpressed in acute myeloid leukemia and is associated with FLT3 internal tandem duplications
RUNX1A isoform is overexpressed in acute myeloid leukemia and is associated with FLT3 internal tandem duplications
RUNX1A is the shortest and least expressed of the RUNX1 three main isoforms (A, B, C); despite this, the leukemogenic role...
Integrated multidimensional bioinformatics analysis of the molecular mechanisms of ulcerative colitis-associated colorectal cancer and MMP1 as a potential therapeutic target
Integrated multidimensional bioinformatics analysis of the molecular mechanisms of ulcerative colitis-associated colorectal cancer and MMP1 as a potential therapeutic target
This study aimed to investigate the molecular mechanisms underlying ulcerative colitis (UC)-associated colorectal cancer (...
Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer
Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer
Ovarian cancers are still largely treated with platinum-based chemotherapy as the standard of care, yet few biomarkers of ...
Correction: SEMA7A-mediated juxtacrine stimulation of IGFBP-3 upregulates IL-17RB at pancreatic cancer invasive front
Correction: SEMA7A-mediated juxtacrine stimulation of IGFBP-3 upregulates IL-17RB at pancreatic cancer invasive front
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 ...
The antitumor peptide M1-20 induced the degradation of CDK1 through CUL4-DDB1-DCAF1-involved ubiquitination
The antitumor peptide M1-20 induced the degradation of CDK1 through CUL4-DDB1-DCAF1-involved ubiquitination
CDK1 is an oncogenic serine/threonine kinase known to play an important role in the regulation of the cell cycle. FOXM1, a...
Reversible downregulation of MYC in a spheroid model of metastatic epithelial ovarian cancer
Reversible downregulation of MYC in a spheroid model of metastatic epithelial ovarian cancer
Upon detachment from the primary tumour, epithelial ovarian cancer cells can form multicellular aggregates, also referred ...
Establishment and characterization of the first immortalized vocal cord leukoplakia epithelial cell line
Establishment and characterization of the first immortalized vocal cord leukoplakia epithelial cell line
The importance of vocal cord leukoplakia (VCL) in the etiology and progression of laryngeal carcinoma has gained increasin...
Soft tissue sarcomas at the single-cell and spatial resolution: new markers and targets
Soft tissue sarcomas at the single-cell and spatial resolution: new markers and targets
Soft tissue sarcomas (STS) are heterogeneous and aggressive tumors, originating in connective tissues embryologically deri...
CCDC34 maintains stemness phenotype through β-catenin-mediated autophagy and promotes EGFR-TKI resistance in lung adenocarcinoma
CCDC34 maintains stemness phenotype through β-catenin-mediated autophagy and promotes EGFR-TKI resistance in lung adenocarcinoma
Despite recent advances in treatment strategy, lung cancer remains the leading cause of cancer-related mortality worldwide...
Correction: A model of breast cancer meningeal metastases: characterization with in vivo molecular imaging
Correction: A model of breast cancer meningeal metastases: characterization with in vivo molecular imaging
Authors and AffiliationsDepartment of Surgery, Massachusetts General Hospital, Boston, MA, USADarshini Kuruppu & Kenne...
Editorial Expression of Concern: E1A-induced apoptosis does not prevent replication of adenoviruses with deletion of E1b in majority of infected cancer cells
Brown Cancer Center, University of Louisville Medical School, Louisville, Kentucky, 40202, USAXiao-Mei Rao, Xinyu Zheng, Y...
PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
Intrahepatic cholangiocarcinoma (iCCA) is a subtype of CCA and has a high mortality rate and a relatively poor prognosis. ...
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
Macrophages are heterogeneous cells that play multifaceted roles in cancer progression and metastasis. However, the phenot...
Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis
Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis
This study was designed to investigate the role and mechanism of cancer-associated fibroblasts (CAFs)-derived exosomes (CA...
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Since trastuzumab was approved in 2012 for the first-line treatment of gastric cancer (GC), no significant advancement in ...
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
MSCs (mesenchymal stem cells), responsible for tissue repair, rarely undergo cell fusion with somatic cells. Here, we show...
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
TNFRSF19 is a member of the tumor necrosis factor receptor superfamily, and its function exhibits variability among differ...
Load More
format_indent_increase