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BRMDA: prediction model for potential microbe-drug associations based on bilinear attention networks and random forest
IntroductionUncharted microbe-drug relationships constitute an under-exploited reservoir of therapeutic leads. In this man...
Correction: A systematic exploration of gut microbiota–driven blood metabolites in sepsis: an integrated bioinformatics and genetic association study
Incorrect funding.The funder Chongqing Natural Science Foundation, CSTB2024NSCQ-KJFZMSX0101 to Peng Zhu was erroneously om...
Pan-transcriptome analysis of pine wilt disease-resistant and susceptible Pinus species and a hybrid
Pine trees, globally distributed and economically vital evergreen conifers, are threatened by pine wilt disease (PWD) attr...
Case Report: Novel pathogenic variant in autosomal recessive WNT10A-related odonto-onycho-dermal dysplasia
Odonto-onycho-dermal dysplasia (OODD) is a rare, autosomal recessive disorder caused by pathogenic variants in the WNT10A ...
Advances in algorithms for normalizer gene selection in qRT-PCR: implications for cancer biology and precision medicine
Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR) plays a significant role in gene expression analysi...
Tumor microenvironment-induced epigenetic reprogramming of Tregs and its impact on immunotherapy
The tumor microenvironment (TME) represents a complex system comprising various cells and extracellular matrix components ...
Developmental and epileptic encephalopathies with germline PIGA variants in five Chinese children: a case report and literature review
BackgroundDiseases associated with the germline PIGA gene include multiple congenital anomalies-hypotonia-seizures syndrom...
Pharmacist workforce training in pharmacogenomics with a focus on rural and underserved areas
ObjectiveOur primary objective is to demonstrate the benefits of pharmacogenomic (PGx) education for pharmacists that serv...
Expanding the clinical and mutational spectrum of hereditary spastic paraplegia type 4 in a cohort of patients from central China
BackgroundMutations in the SPAST gene cause autosomal dominant hereditary spastic paraplegia (HSP) type 4 (SPG4), which is...
Raloxifene ameliorates cartilage and subchondral bone microstructural degeneration in the ovariectomy-induced spontaneous postmenopausal osteoarthritis
The prevalence and incidence of osteoarthritis (OA) increase significantly in women after menopause, indicating an importa...
Case Report: Prenatal genetic analysis of a rare fetus with 45, X/46, X, dic r (Y; Y)/46, X, r(Y) karyotype
ObjectiveTo perform a genetic analysis of a rare complex chimeric fetus with a 45,X/46,X,dic r(Y; Y)/46,X,r(Y) karyotype, ...
Renpenning syndrome caused by the c.459_462delAGAG mutation in PQBP1: a case report and literature review
BackgroundRenpenning syndrome (OMIM: 309500) is a rare X-linked intellectual disability caused by variations in the polygl...
A graph clustering algorithm with hypergraph learning and a core-attachment strategy for protein complex identification
Protein complexes play a crucial role in cellular biological processes. Identifying these complexes is essential for under...
Editorial: Advances in molecular genetics of Marfan syndrome and related disorders
Marfan syndrome (MFS, OMIM#154700) is a rare heritable multisystem connective tissue disorder 9 (HCTD) with an estimated i...
Genomic and transcriptomic insights into aflatoxin-induced intrahepatic cholangiocarcinoma: an integrated pathway and meta-analysis study
IntroductionEnvironmental and chemical exposures are major yet incompletely characterized drivers of human carcinogenesis....
A single-cell multi-omics atlas of human eyelid skin
Human skin acts as a primary protective organ against the external environment. It plays key physiological roles, includin...
Genetic association of LOC100130476 rs80213143 with susceptibility and renal involvement in systemic lupus erythematosus
BackgroundsSystemic lupus erythematosus (SLE) is an autoimmune disease with multi-organ involvement, and lupus nephritis (...
Serum tumor markers combined with HRCT for malignancy risk assessment of solitary pulmonary nodules: a retrospective study
IntroductionThis study aims to investigate the correlation between serum tumor markers (CEA, NSE, CA-125, and CYFRA 21-1) ...
Federated, governed, and interoperable? The emerging architecture of public human genomic data infrastructures: a European perspective
Public infrastructures for human genomic data are increasingly incorporating federated approaches alongside centralized an...
TTN variants in pediatric cardiomyopathy: a retrospective cohort study
BackgroundTitin (TTN) variants have been implicated in various types of cardiomyopathy. Allelic variant heterogeneity resu...
Novel variant alters splicing of TGFB2 in family with features of Loeys-Dietz syndrome
1 IntroductionLoeys-Dietz syndrome (LDS) is a rare connective tissue disorder with a prevalence of 1 in 100,000 individual...
SiMul-db: a database of single and multi-target Cas9 guides for hazelnut editing
Hazelnuts are trees belonging to the Betulaceae family and Corylus genus (Wani et al., 2020). Due to their delicious flavo...
Localization is the key to action: regulatory peculiarities of lncRNAs
To understand the transcriptomic profile of an individual cell in a multicellular organism, we must comprehend its surroun...
Identification and validation the predictive biomarkers based on risk-adjusted control chart in gemcitabine with or without erlotinib for pancreatic cancer therapy
1 IntroductionPancreatic ductal adenocarcinoma (PDAC) is a common gastrointestinal malignancy with a 5-year survival rate ...
Genome-wide identification and expression analysis of the PsKIN gene family in pea
1 IntroductionPeas (Pisum sativum L.) are integral to the global agricultural and nutritional sectors. Despite their impor...
The risk status, signatures of adaptation, and environmental suitability of village-based indigenous chickens from certain regions of Limpopo and KwaZulu-Natal provinces of South Africa
IntroductionIn South Africa, as in most developing countries, indigenous chickens contribute significantly to the liveliho...
Assessing the causal relationships between circulating metabolic biomarkers and breast cancer by using mendelian randomization
1 IntroductionBreast cancer (BC) remains the most common cancer among women globally. In 2024, the United States is expect...
Identification of hub programmed cell death-related genes and immune infiltration in Crohn’s disease using bioinformatics
1 IntroductionCrohn’s disease (CD) is an inflammatory bowel disease affecting any part of the gastrointestinal tract (Peta...
Identification of selective sweep and associated QTL traits in Iranian Ovis aries and Ovis orientalis populations
1 IntroductionAnimal domestication has significantly influenced human life. Due to their high adaptability to various clim...
Genome-wide identification and expression analysis of the BAHD gene family in Leonurus japonicus
1 IntroductionSecondary metabolites endowed with specialized bioactivity are integral to the growth and developmental proc...
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