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The epigenetics of frailty
The epigenetics of frailty
The conceptual change of frailty, from a physical to a biopsychosocial phenotype, expanded the field of frailty, including...
SET protein as an epigenetics target
SET protein as an epigenetics target
The SET gene has four transcripts reported in NCBI, coding two isoforms of SET proteins. The most known function of SET pr...
DNA methylation as a window into female reproductive aging
DNA methylation as a window into female reproductive aging
People with ovaries experience reproductive aging as their reproductive function and system declines. This has significant...
Hypomethylation of Wnt signaling regulator genes in developmental language disorder
Hypomethylation of Wnt signaling regulator genes in developmental language disorder
Background: Developmental language disorder (DLD) is a neurodevelopmental disorder. Considering the pivotal role of epigen...
Twin study: genotype-dependent epigenetic factors affecting free thyroxine levels in the normal range
Twin study: genotype-dependent epigenetic factors affecting free thyroxine levels in the normal range
Aim: To explore the clinical application of DNA methylation affecting thyroid function, we evaluated the association of DN...
Integrated analysis of transcriptome and epigenome reveals ENSR00000272060 as a potential biomarker in gastric cancer
Integrated analysis of transcriptome and epigenome reveals ENSR00000272060 as a potential biomarker in gastric cancer
Background: Enhancer RNAs (eRNAs) are involved in gene expression regulation. Although functional roles of eRNAs in the pa...
microRNAs and their therapeutic strategy in phase I and phase II clinical trials
microRNAs and their therapeutic strategy in phase I and phase II clinical trials
miRNAs play a crucial therapeutic role in diseases such as cancer, diabetes and viral infections, with around 1900 identif...
Mitochondrial D-loop methylation levels inversely correlate with disease duration in amyotrophic lateral sclerosis
Mitochondrial D-loop methylation levels inversely correlate with disease duration in amyotrophic lateral sclerosis
Aim: To correlate mitochondrial D-loop region methylation levels and mtDNA copy number with disease duration in familial a...
Data science using the human epigenome for predicting multifactorial diseases and symptoms
Data science using the human epigenome for predicting multifactorial diseases and symptoms
Tweetable abstract This article reviews machine learning models that leverages epigenomic data for predicting multifactori...
POU2F2-mediated upregulation of lncRNA PTPRG-AS1 inhibits ferroptosis in breast cancer via miR-376c-3p/SLC7A11 axis
POU2F2-mediated upregulation of lncRNA PTPRG-AS1 inhibits ferroptosis in breast cancer via miR-376c-3p/SLC7A11 axis
Background: Triple-negative breast cancer (TNBC) is a subtype of BC with high rates of mortality. The mechanism of PTPRG-A...
Unlocking the epigenetic symphony: histone acetylation's impact on neurobehavioral change in neurodegenerative disorders
Unlocking the epigenetic symphony: histone acetylation's impact on neurobehavioral change in neurodegenerative disorders
Recent genomics and epigenetic advances have empowered the exploration of DNA/RNA methylation and histone modifications cr...
LncRNA-ENST00000421645 promotes T cells to secrete IFN-γ by sponging PCM-1 in neurosyphilis
Aim: Neurosyphilis patients exhibited significant expression of long noncoding RNA (lncRNA) in peripheral blood T lymphocy...
DNA methylation detection technology and plasma-based methylation biomarkers in screening of gastrointestinal carcinoma
DNA methylation is of paramount importance for the evolution of human cancers. Its high sensitivity and specificity make i...
Novel epigenetic link between gestational diabetes mellitus and macrosomia
Background & objectives: Examine maternal gestational diabetes mellitus (GDM), macrosomia and DNA methylation in candi...
NEAT1 functions as a key mediator of BMP2 to promote osteogenic differentiation of renal interstitial fibroblasts
Aim: To clarify the mechanism of NEAT1, an aberrantly upregulated lncRNA in Randall's plaques (RP) similar to biomineraliz...
DNA methylation differences in cortical grey and white matter in schizophrenia
Aim: Identify grey- and white-matter-specific DNA-methylation differences between schizophrenia (SCZ) patients and control...
LINC01133 hampers the development of gastric cancer through increasing SST via binding to microRNA-576-5p
Aim: Our study aimed at investigating how LINC01133 functions in gastric cancer (GC) progression. Materials & methods:...
Cataloging recent advances in epigenetic alterations in major mental disorders and autism
During the last two decades, diverse epigenetic modifications including DNA methylation, histone modifications, RNA editin...
Predicting outcome in higher-risk myelodysplastic syndrome patients treated with azacitidine
5-Azacitidine (5-AZA) is widely used for the treatment of higher-risk myelodysplastic syndromes. However, response and sur...
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